Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin

• Published in: Journal of diabetes and its complications Vol. 35; no. 7; p. 107947
• Main Authors: Mostafa, Tarek M., Hegazy, Sahar K., Elnaidany, Sherin S., Shehabeldin, Walid A., Sawan, Eman S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2021; Elsevier Limited
• Subjects: Antidiabetics; Blood Glucose; Body mass index; Calories; Cholesterol; Diabetes; Ethics; Exercise; Gene expression; Glucose; Hemoglobin; Homeostasis; Hospitals; Humans; Inflammation - drug therapy; Inflammatory diseases; Insulin resistance; Intervention; Life Style; Lifestyles; Metabolism; Metformin - therapeutic use; Nigella sativa; Nigella sativa - chemistry; Obesity; Obesity - complications; Obesity - therapy; p53; Pharmaceutical industry; Physical fitness; Plant Preparations - therapeutic use; Prediabetes; Prediabetic State - complications; Prediabetic State - drug therapy; Prevention; Senescence; SIRT1; Sirtuin 1; TNF-α; United States > US; Spain; TNF-α; Prediabetes; Nigella sativa; SIRT1; p53

This study aimed at evaluating the effect of Nigella sativa (NS) on anthropometric, metabolic and inflammatory parameters and examining its related molecular mechanisms in obese prediabetic individuals as compared to both lifestyle modification (LM) and Metformin (Met). This study included 117 obese...