A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence

• Published in: Bioorganic & medicinal chemistry Vol. 26; no. 19; pp. 5336 - 5342
• Main Authors: Boursier, Michelle E., Manson, Daniel E., Combs, Joshua B., Blackwell, Helen E.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.10.2018; Elsevier
• Subjects: 4-Butyrolactone - analogs & derivatives; 4-Butyrolactone - chemical synthesis; 4-Butyrolactone - chemistry; 4-Butyrolactone - pharmacology; Bacterial Proteins - agonists; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - metabolism; Biochemistry & Molecular Biology; Chemistry; Chemistry, Medicinal; Chemistry, Organic; LasR; Life Sciences & Biomedicine; Ligands; N-(3-oxo)-dodecanoyl l-homoserine lactone; Pharmacology & Pharmacy; Physical Sciences; Pseudomonas aeruginosa; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - pathogenicity; QscR; Quorum sensing; Repressor Proteins - agonists; Repressor Proteins - antagonists & inhibitors; Repressor Proteins - metabolism; Science & Technology; Trans-Activators - agonists; Trans-Activators - antagonists & inhibitors; Trans-Activators - metabolism; Virulence - drug effects; LasR; Pseudomonas aeruginosa; Quorum sensing; N-(3-oxo)-dodecanoyl l-homoserine lactone; QscR; DESIGN; CRYSTAL-STRUCTURE; MODULATORS; AUTOINDUCER; SYNTHETIC LIGANDS; INHIBITION; BIOLOGICAL EVALUATION; N-(3-oxo)-dodecanoyl L-homoserine lactone; BIOFILM FORMATION

[Display omitted] Certain bacteria can coordinate group behaviors via a chemical communication system known as quorum sensing (QS). Gram-negative bacteria typically use N-acyl l-homoserine lactone (AHL) signals and their cognate intracellular LuxR-type receptors for QS. The opportunistic pathogen Ps...