Determination of cocaine adulterants in human urine by dispersive liquid-liquid microextraction and high-performance liquid chromatography

This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained...

Full description

Saved in:
Bibliographic Details
Published inAnalytical and bioanalytical chemistry Vol. 411; no. 16; pp. 3447 - 3461
Main Authors da Silva, Pedro Rafael, Sena, Laís Cristina Santana, Silva, Rubens Pedro Lorena, de Santana, Danielle Cristine Almeida Silva, de Santana, Fernando José Malagueño
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2019
Springer
Springer Nature B.V
Subjects
Acetanilide
Acetonitrile
Acute intoxication
Adulterants
Alkalizing
Analytical Chemistry
Biochemistry
Caffeine
Characterization and Evaluation of Materials
Chemical properties
Chemistry
Chemistry and Materials Science
Chloroform
Chromatography
Cocaine
Dependence
Design of experiments
Diltiazem
Dispersion
Drug abuse
Elution
Experimental design
Extraction (Chemistry)
Food Science
Freeze thaw cycles
Freeze-thawing
High performance liquid chromatography
Human wastes
Identification and classification
Intoxication
Ions
Laboratory Medicine
Lidocaine
Liquid chromatography
Liquid-liquid extraction
Methods
Monitoring/Environmental Analysis
pH effects
Phenacetin
Research Paper
Selectivity
Sodium chloride
Sodium phosphate
Solvents
Stability tests
Trifluoroacetic acid
Urine
Dispersive liquid-liquid microextraction
Urine drug testing
Liquid chromatography
Street cocaine
Drug adulteration
Online AccessGet full text

Cover

Abstract This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained in gradient elution mode using methanol:water plus trifluoroacetic acid 0.15% ( v / v ) (pH = 1.9) at 1 mL min −1 as mobile phase, at 25 °C, detection at 235 nm, and analysis time of 20 min. The effect of major DLLME operating parameters on extraction efficiency was explored using the multifactorial experimental design approach. The optimum extraction condition was set as 4 mL human urine sample alkalized with 0.5 M sodium phosphate buffer (pH 12), NaCl (15%, m / v ), 300 μL acetonitrile (dispersive solvent), and 800 μL chloroform (extraction solvent). Linear response ( r 2  ≥ 0.99) was obtained in the range of 180–1500 ng mL −1 with suitable selectivity, quantification limit (180 ng mL −1 ), mean recoveries (33.43–76.63%), and showing relative standard deviation and error (within and between-day assays) ≤15%. The analytes were stable after a freeze-thaw cycle and a short-term room temperature stability test. This method was successfully applied in real samples of cocaine users, suggesting that our study may contribute to the appropriate treatment of cocaine dependence or with the cases of cocaine acute intoxication.
AbstractList This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained in gradient elution mode using methanol:water plus trifluoroacetic acid 0.15% (v/v) (pH = 1.9) at 1 mL min as mobile phase, at 25 °C, detection at 235 nm, and analysis time of 20 min. The effect of major DLLME operating parameters on extraction efficiency was explored using the multifactorial experimental design approach. The optimum extraction condition was set as 4 mL human urine sample alkalized with 0.5 M sodium phosphate buffer (pH 12), NaCl (15%, m/v), 300 μL acetonitrile (dispersive solvent), and 800 μL chloroform (extraction solvent). Linear response (r  ≥ 0.99) was obtained in the range of 180-1500 ng mL with suitable selectivity, quantification limit (180 ng mL ), mean recoveries (33.43-76.63%), and showing relative standard deviation and error (within and between-day assays) ≤15%. The analytes were stable after a freeze-thaw cycle and a short-term room temperature stability test. This method was successfully applied in real samples of cocaine users, suggesting that our study may contribute to the appropriate treatment of cocaine dependence or with the cases of cocaine acute intoxication.
This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained in gradient elution mode using methanol:water plus trifluoroacetic acid 0.15% (v/v) (pH = 1.9) at 1 mL min−1 as mobile phase, at 25 °C, detection at 235 nm, and analysis time of 20 min. The effect of major DLLME operating parameters on extraction efficiency was explored using the multifactorial experimental design approach. The optimum extraction condition was set as 4 mL human urine sample alkalized with 0.5 M sodium phosphate buffer (pH 12), NaCl (15%, m/v), 300 μL acetonitrile (dispersive solvent), and 800 μL chloroform (extraction solvent). Linear response (r2 ≥ 0.99) was obtained in the range of 180–1500 ng mL−1 with suitable selectivity, quantification limit (180 ng mL−1), mean recoveries (33.43–76.63%), and showing relative standard deviation and error (within and between-day assays) ≤15%. The analytes were stable after a freeze-thaw cycle and a short-term room temperature stability test. This method was successfully applied in real samples of cocaine users, suggesting that our study may contribute to the appropriate treatment of cocaine dependence or with the cases of cocaine acute intoxication.
This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained in gradient elution mode using methanol:water plus trifluoroacetic acid 0.15% (v/v) (pH = 1.9) at 1 mL min.sup.-1 as mobile phase, at 25 °C, detection at 235 nm, and analysis time of 20 min. The effect of major DLLME operating parameters on extraction efficiency was explored using the multifactorial experimental design approach. The optimum extraction condition was set as 4 mL human urine sample alkalized with 0.5 M sodium phosphate buffer (pH 12), NaCl (15%, m/v), 300 [mu]L acetonitrile (dispersive solvent), and 800 [mu]L chloroform (extraction solvent). Linear response (r.sup.2 [greater than or equal to] 0.99) was obtained in the range of 180-1500 ng mL.sup.-1 with suitable selectivity, quantification limit (180 ng mL.sup.-1), mean recoveries (33.43-76.63%), and showing relative standard deviation and error (within and between-day assays) [less than or equal to]15%. The analytes were stable after a freeze-thaw cycle and a short-term room temperature stability test. This method was successfully applied in real samples of cocaine users, suggesting that our study may contribute to the appropriate treatment of cocaine dependence or with the cases of cocaine acute intoxication.
This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained in gradient elution mode using methanol:water plus trifluoroacetic acid 0.15% ( v / v ) (pH = 1.9) at 1 mL min −1 as mobile phase, at 25 °C, detection at 235 nm, and analysis time of 20 min. The effect of major DLLME operating parameters on extraction efficiency was explored using the multifactorial experimental design approach. The optimum extraction condition was set as 4 mL human urine sample alkalized with 0.5 M sodium phosphate buffer (pH 12), NaCl (15%, m / v ), 300 μL acetonitrile (dispersive solvent), and 800 μL chloroform (extraction solvent). Linear response ( r 2  ≥ 0.99) was obtained in the range of 180–1500 ng mL −1 with suitable selectivity, quantification limit (180 ng mL −1 ), mean recoveries (33.43–76.63%), and showing relative standard deviation and error (within and between-day assays) ≤15%. The analytes were stable after a freeze-thaw cycle and a short-term room temperature stability test. This method was successfully applied in real samples of cocaine users, suggesting that our study may contribute to the appropriate treatment of cocaine dependence or with the cases of cocaine acute intoxication.
Audience Academic
Author de Santana, Fernando José Malagueño
Sena, Laís Cristina Santana
da Silva, Pedro Rafael
Silva, Rubens Pedro Lorena
de Santana, Danielle Cristine Almeida Silva
Author_xml – sequence: 1
  givenname: Pedro Rafael
  surname: da Silva
  fullname: da Silva, Pedro Rafael
  organization: Pharmaceutical Science Department, Federal University of Pernambuco
– sequence: 2
  givenname: Laís Cristina Santana
  surname: Sena
  fullname: Sena, Laís Cristina Santana
  organization: Laboratory of Forensic Toxicology, Criminalistics Institute, Secretary of Social Defense of Pernambuco
– sequence: 3
  givenname: Rubens Pedro Lorena
  surname: Silva
  fullname: Silva, Rubens Pedro Lorena
  organization: Pharmaceutical Science Department, Federal University of Pernambuco
– sequence: 4
  givenname: Danielle Cristine Almeida Silva
  surname: de Santana
  fullname: de Santana, Danielle Cristine Almeida Silva
  organization: Pharmaceutical Science Department, Federal University of Pernambuco
– sequence: 5
  givenname: Fernando José Malagueño
  surname: de Santana
  fullname: de Santana, Fernando José Malagueño
  email: fmalagueno@hotmail.com
  organization: Pharmaceutical Science Department, Federal University of Pernambuco
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31123783$$D View this record in MEDLINE/PubMed
BookMark eNp9UctuHCEQRJGt-PkDOURIOY9D8xiGo-U8JUu5xGfEMLCDtQNrmImy_oR8dViP7dwihLpFVxVdqjN0FFN0CL0DcgWEyI-FEAptQ0DVK5VsHt-gU2iha2gryNFrz-kJOivlnhAQHbRv0QkDoEx27BT9-eRml6cQzRxSxMljm6wJ0WEzLNs6MnEuOEQ8LpOJeMmHUb_HQyg7l0v45fA2PCxhaNaCp2Bzcr_nbOyTookDHsNmbCrcp1xF7AsF2zGnycxpk81u3F-gY2-2xV0-13N09-Xzz5tvze2Pr99vrm8bywXMjVItU4xLaduW-44ZqRQF28leMm4M554I6ZzsPPXAhRssWCMc64Tquec9O0cfVt1dTg-LK7O-T0uO9UtNKVWCKGCioq5W1MZsnQ7Rp4OlegZXLdYgfKjv16JTtFMAvBLoSqj-S8nO610Ok8l7DUQf8tJrXrrmpZ_y0o-V9P55l6Wf3PBKeQmoAtgKKHUUNy7_W_Y_sn8BVHqlyQ
CitedBy_id crossref_primary_10_1016_j_ijoes_2023_100134
crossref_primary_10_4155_bio_2021_0237
crossref_primary_10_1016_j_microc_2020_105332
crossref_primary_10_1039_D1AY00932J
crossref_primary_10_1039_D1AN01173A
crossref_primary_10_1007_s13738_022_02642_4
crossref_primary_10_1016_j_chroma_2021_462444
crossref_primary_10_1080_03067319_2021_2014473
crossref_primary_10_1002_wfs2_1497
crossref_primary_10_1016_j_talo_2021_100079
crossref_primary_10_1016_j_forc_2024_100554
crossref_primary_10_3390_toxins13110793
Cites_doi 10.1016/j.jpba.2014.01.044
10.1016/j.chroma.2006.03.007
10.1016/j.forsciint.2018.02.001
10.5935/0103-5053.20150088
10.1016/S0006-8993(96)01004-9
10.1016/j.chroma.2014.12.012
10.1016/j.jchromb.2016.08.040
10.1016/j.jchromb.2017.07.055
10.1016/j.forsciint.2014.11.028
10.1016/j.talanta.2014.12.008
10.1111/j.1360-0443.2009.02532.x
10.1016/j.jpba.2017.07.059
10.1017/S1368980014001657
10.1016/S0008-6363(02)00846-5
10.1001/jamainternmed.2017.4765
10.1016/j.tox.2016.04.008
10.1016/j.jchromb.2010.06.005
10.1016/j.jpba.2012.03.036
10.1093/chromsci/bmw051
10.1016/j.trac.2018.10.022
10.1016/j.aca.2007.10.037
10.1155/2014/434717
10.1016/j.jchromb.2014.07.019
10.1007/s12640-018-9887-1
10.1016/j.jpba.2017.11.024
10.1016/j.microc.2015.05.009
10.1021/ac00218a019
10.1007/s00216-013-7344-9
10.1097/PAF.0b013e3181ed79fe
10.1016/j.foodchem.2010.12.054
10.1016/j.forsciint.2015.02.006
10.1016/j.jchemneu.2017.06.001
10.1016/j.jscs.2011.11.005
10.2174/157341108783339070
10.2174/1389201018666170710184531
10.5935/0103-5053.20140008
10.1007/s00213-016-4320-z
10.1039/C3AY41907J
10.1016/j.teac.2017.03.001
10.1016/j.forsciint.2015.09.014
10.1016/j.forsciint.2016.02.033
10.1016/j.drugpo.2010.03.004
10.1016/j.chemosphere.2016.12.019
10.1111/ajad.12245
10.1016/j.ajem.2013.02.022
10.1136/heart.89.11.1363
10.4155/bio.15.141
ContentType Journal Article
Copyright Springer-Verlag GmbH Germany, part of Springer Nature 2019
COPYRIGHT 2019 Springer
Analytical and Bioanalytical Chemistry is a copyright of Springer, (2019). All Rights Reserved.
Copyright_xml – notice: Springer-Verlag GmbH Germany, part of Springer Nature 2019
– notice: COPYRIGHT 2019 Springer
– notice: Analytical and Bioanalytical Chemistry is a copyright of Springer, (2019). All Rights Reserved.
DBID NPM
AAYXX
CITATION
3V.
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
7U7
7X7
7XB
88E
8BQ
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
F28
FR3
FYUFA
GHDGH
GNUQQ
H8D
H8G
HCIFZ
JG9
JQ2
K9.
KB.
KR7
L7M
LK8
L~C
L~D
M0S
M1P
M7P
P64
PDBOC
PQEST
PQQKQ
PQUKI
DOI 10.1007/s00216-019-01797-z
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
Aluminium Industry Abstracts
Biotechnology Research Abstracts
Ceramic Abstracts
Computer and Information Systems Abstracts
Corrosion Abstracts
Electronics & Communications Abstracts
Engineered Materials Abstracts
Materials Business File
Mechanical & Transportation Engineering Abstracts
Solid State and Superconductivity Abstracts
Toxicology Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
METADEX
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central
ANTE: Abstracts in New Technology & Engineering
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Aerospace Database
Copper Technical Reference Library
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
Materials Research Database
ProQuest Computer Science Collection
ProQuest Health & Medical Complete (Alumni)
https://resources.nclive.org/materials
Civil Engineering Abstracts
Advanced Technologies Database with Aerospace
Biological Sciences
Computer and Information Systems Abstracts – Academic
Computer and Information Systems Abstracts Professional
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Biotechnology and BioEngineering Abstracts
Materials Science Collection
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
DatabaseTitle PubMed
CrossRef
Materials Research Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Computer Science Collection
Computer and Information Systems Abstracts
SciTech Premium Collection
Materials Business File
Environmental Sciences and Pollution Management
Engineered Materials Abstracts
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
ANTE: Abstracts in New Technology & Engineering
Aluminium Industry Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Electronics & Communications Abstracts
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Ceramic Abstracts
Biological Science Database
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Solid State and Superconductivity Abstracts
Engineering Research Database
ProQuest One Academic
Technology Collection
Technology Research Database
Computer and Information Systems Abstracts – Academic
Mechanical & Transportation Engineering Abstracts
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central
Aerospace Database
Copper Technical Reference Library
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Materials Science Database
Advanced Technologies Database with Aerospace
ProQuest Materials Science Collection
Civil Engineering Abstracts
Toxicology Abstracts
ProQuest SciTech Collection
METADEX
Computer and Information Systems Abstracts Professional
ProQuest Medical Library
Materials Science & Engineering Collection
Corrosion Abstracts
ProQuest Central (Alumni)
DatabaseTitleList PubMed
Materials Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1618-2650
EndPage 3461
ExternalDocumentID A589289114
10_1007_s00216_019_01797_z
31123783
Genre Journal Article
GrantInformation_xml – fundername: Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco
  funderid: http://dx.doi.org/10.13039/501100006162
– fundername: Conselho Nacional de Desenvolvimento Científico e Tecnológico
  funderid: http://dx.doi.org/10.13039/501100003593
GroupedDBID ---
-58
-5G
-BR
-EM
-~C
.86
.VR
06C
06D
0VY
199
1N0
203
23M
2J2
2JN
2JY
2KG
2KM
2LR
2~H
30V
4.4
406
408
409
40D
40E
5VS
67Z
6NX
78A
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
A8Z
AAAVM
AABHQ
AAFGU
AAHNG
AAIAL
AAJKR
AANZL
AAPBV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
ABBBX
ABBXA
ABDBF
ABDZT
ABECU
ABFGW
ABFTV
ABHLI
ABHQN
ABIPD
ABJCF
ABJNI
ABJOX
ABKAS
ABKCH
ABKTR
ABLJU
ABMNI
ABMQK
ABNWP
ABPTK
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABUWG
ABWNU
ABXPI
ACBMV
ACBRV
ACBYP
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACIWK
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACTTH
ACVWB
ACWMK
ADBBV
ADHIR
ADIMF
ADINQ
ADJJI
ADKNI
ADKPE
ADMDM
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AENEX
AEOHA
AEPYU
AESKC
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFKRA
AFLOW
AFNRJ
AFQWF
AFRAH
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGJBK
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHMBA
AHSBF
AHYZX
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJDOV
AJRNO
AJZVZ
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AYJHY
AZFZN
B-.
B0M
BA0
BBNVY
BENPR
BGLVJ
BGNMA
BHPHI
BPHCQ
BVXVI
CCPQU
CS3
CSCUP
D1I
DDRTE
DL5
DNIVK
DPUIP
EAD
EAP
EBD
EBLON
EBS
EIOEI
EJD
EMK
EMOBN
EPAXT
EPL
ESBYG
ESTFP
ESX
F5P
FEDTE
FERAY
FFXSO
FIGPU
FNLPD
FRRFC
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GXS
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IAO
IFM
IGS
IHE
IJ-
IKXTQ
IMOTQ
INH
INR
ITC
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KB.
KDC
KOV
LK8
LLZTM
M1P
M4Y
M7P
MA-
ML-
N9A
NB0
NPVJJ
NQJWS
NU0
O93
O9G
O9I
O9J
OAM
P19
P2P
P9N
PDBOC
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
QOK
QOR
QOS
R89
R9I
RNS
ROL
RPX
RRX
RSV
S16
S27
S3B
SAP
SCM
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SQXTU
SRMVM
SSLCW
STPWE
SV3
SZN
T13
TSG
TSK
TSV
TUC
TUS
U2A
U9L
UG4
UKHRP
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WH7
WJK
WK8
YLTOR
Z45
Z5O
Z7R
Z7S
Z7U
Z7V
Z7W
Z7X
Z7Y
Z7Z
Z81
Z82
Z83
Z85
Z86
Z87
Z88
Z8M
Z8N
Z8O
Z8P
Z8Q
Z8R
Z8S
Z8T
Z8U
Z8V
Z8W
Z8Z
Z91
Z92
ZMTXR
~8M
~KM
-Y2
0R~
2P1
2VQ
3V.
53G
AACDK
AAEOY
AAHBH
AAIKT
AAJBT
AARHV
AASML
AAYOK
AAYTO
AAYZH
ABAKF
ABULA
ACAOD
ACBXY
ACDTI
ACZOJ
ADPHR
AEBTG
AEFQL
AEKMD
AEMSY
AFBBN
AFEXP
AFGCZ
AGGDS
AGJZZ
AGQEE
AGRTI
AIGIU
AJBLW
ALIPV
BDATZ
CAG
COF
FINBP
FSGXE
H13
H~9
LAS
N2Q
NDZJH
NPM
RIG
RNI
RZK
S1Z
S26
S28
SCLPG
T16
W4F
AAYXX
CITATION
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
7U7
7XB
8BQ
8FD
8FK
AZQEC
C1K
DWQXO
F28
FR3
GNUQQ
H8D
H8G
JG9
JQ2
K9.
KR7
L7M
L~C
L~D
P64
PQEST
PQUKI
ID FETCH-LOGICAL-c451t-996393477c664f83a79921c87b734aa44f057ee78f2f145edc1ca5e3859b4f4b3
IEDL.DBID 8FG
ISSN 1618-2642
IngestDate Thu Oct 10 20:55:58 EDT 2024
Fri Feb 02 04:34:38 EST 2024
Thu Sep 12 17:43:39 EDT 2024
Wed Oct 16 00:51:44 EDT 2024
Sat Dec 16 12:01:38 EST 2023
IsPeerReviewed true
IsScholarly true
Issue 16
Keywords Dispersive liquid-liquid microextraction
Urine drug testing
Liquid chromatography
Street cocaine
Drug adulteration
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c451t-996393477c664f83a79921c87b734aa44f057ee78f2f145edc1ca5e3859b4f4b3
PMID 31123783
PQID 2229509135
PQPubID 2034506
PageCount 15
ParticipantIDs proquest_journals_2229509135
gale_infotracacademiconefile_A589289114
crossref_primary_10_1007_s00216_019_01797_z
pubmed_primary_31123783
springer_journals_10_1007_s00216_019_01797_z
PublicationCentury 2000
PublicationDate 2019-06-01
PublicationDateYYYYMMDD 2019-06-01
PublicationDate_xml – month: 06
  year: 2019
  text: 2019-06-01
  day: 01
PublicationDecade 2010
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
– name: Germany
– name: Heidelberg
PublicationTitle Analytical and bioanalytical chemistry
PublicationTitleAbbrev Anal Bioanal Chem
PublicationTitleAlternate Anal Bioanal Chem
PublicationYear 2019
Publisher Springer Berlin Heidelberg
Springer
Springer Nature B.V
Publisher_xml – name: Springer Berlin Heidelberg
– name: Springer
– name: Springer Nature B.V
References Emídio, de Menezes Prata, de Santana, Dórea (CR33) 2010; 878
Prieto, Scorza, Serra, Perra, Galvalisi, Abin-Carriquiry, Piras, Valentini (CR40) 2016; 233
Mansour, Khairy (CR9) 2017; 1061-1062
Kudlacek, Hofmaier, Luf, Mayer, Stockner, Nagy, Holy, Freissmuth, Schmid, Sitte (CR41) 2017; 83-84
CR32
Billman (CR43) 1993; 266
CR31
Kurowska-Susdorf, Zwierzdzynski, Bevanda, Talic, Ivankovic, Płotka-Wasylka (CR1) 2019; 111
Bianchi, Careri (CR34) 2008; 4
Solimini, Rotolo, Pellegrini, Minutillo, Pacifici, Busardò, Zaami (CR16) 2017; 18
Jafari, Rezaei, Javaheri (CR28) 2011; 126
Lapachinske, Okai, Santos, Bairros, Yonamine (CR17) 2015; 247
Rezaee, Assadi, Hosseini, Aghaee, Ahmadi, Berijani (CR3) 2006; 1116
Molina, Hargrove (CR50) 2011; 32
Souied, Baydoun, Ghandour, Mobarakai (CR23) 2014; 2014
Mahler, Hartung, Plässer, Daldrup (CR30) 2015; 249
Brunt, Rigter, Hoek, Vogels, Van Dijk, Niesink (CR20) 2009; 104
Ahmadi-Jouibari, Fattahi, Shamsipur (CR35) 2014; 94
Zuloaga, Olivares, Navarro, Vallejo, Prieto (CR11) 2015; 7
Al-Saidi, Emara (CR7) 2014; 18
Pea (CR45) 2017; 177
Bro, Smilde (CR37) 2014; 6
Fisichella, Odoardi, Strano-Rossi (CR12) 2015; 123
Jouyban, Sorouraddin, Farajzadeh, Somi, Fazeli-Bakhtiyari (CR36) 2015; 134
Arthur, Pawliszyn (CR4) 1990; 62
Primel, Caldas, Marube, Escarrone (CR6) 2017; 14
Prieto, Galvalisi, López-Hill, Meikle, Abin-Carriquiry, Scorza (CR39) 2015; 24
Yap, Camm (CR48) 2003; 89
Maldaner, Botelho, Zacca, Camargo, Braga, Grobério (CR18) 2015; 26
Filippou, Bitas, Samanidou (CR2) 2017; 1043
de Santana, Bonato (CR5) 2008; 606
Broséus, Gentile, Bonadio, Garcia, Gasté, Esseiva (CR22) 2015; 257
Broséus, Gentile, Esseiva (CR46) 2016; 262
Saluti, Giusepponi, Moretti, Di Salvo, Galarini (CR26) 2016; 54
Mercieca, Odoardi, Cassar, Strano (CR14) 2018; 149
Pereira, Souza, Duffey, Sichieri, Popkin (CR42) 2015; 18
Knuth, Temme, Daldrup, Pawlik (CR29) 2018; 285
Kohler, Schappler, Sierro, Rudaz (CR13) 2013; 73
Barat, Abdel-Rahman (CR47) 1996; 742
Martins, Dos Santos, Todeschini, Saldanha, da Silva, Reichert, Souza (CR38) 2017; 170
Evrard, Legleye, Cadet-Taïroua (CR21) 2010; 21
Viñas, Campillo, Pastor-Belda, Oller, Hernández-Córdoba (CR10) 2015; 1376
Viñas, Campillo, López-García, Hernández-Córdoba (CR8) 2014; 406
Abin-Carriquiry, Martínez-Busi, Galvalisi, Minteguiaga, Prieto, Scorza (CR24) 2018; 34
Ibrahim, Maselli, Hasan (CR44) 2013; 31
Sena, Matos, Dórea, Pimentel, de Santana, de Santana (CR15) 2017; 376
Li, Li, Lu, Dong (CR27) 2014; 15
Botelho, Cunha, Campos, Maldaner (CR19) 2014; 25
Katselou, Athanaselis, Nikolaou, Dona, Spiliopoulou, Papoutsis (CR25) 2017; 25
Redfern, Carlsson, Davis (CR49) 2003; 58
M Fisichella (1797_CR12) 2015; 123
K Molina (1797_CR50) 2011; 32
GE Billman (1797_CR43) 1993; 266
WS Redfern (1797_CR49) 2003; 58
LC Sena (1797_CR15) 2017; 376
TM Brunt (1797_CR20) 2009; 104
G Mercieca (1797_CR14) 2018; 149
F Bianchi (1797_CR34) 2008; 4
JP Prieto (1797_CR39) 2015; 24
O Zuloaga (1797_CR11) 2015; 7
T Ahmadi-Jouibari (1797_CR35) 2014; 94
I Kohler (1797_CR13) 2013; 73
YG Yap (1797_CR48) 2003; 89
ES Emídio (1797_CR33) 2010; 878
JP Prieto (1797_CR40) 2016; 233
O Filippou (1797_CR2) 2017; 1043
FR Mansour (1797_CR9) 2017; 1061-1062
M Ibrahim (1797_CR44) 2013; 31
AF Martins (1797_CR38) 2017; 170
CL Arthur (1797_CR4) 1990; 62
R Bro (1797_CR37) 2014; 6
J Broséus (1797_CR22) 2015; 257
O Souied (1797_CR23) 2014; 2014
MT Jafari (1797_CR28) 2011; 126
A Kurowska-Susdorf (1797_CR1) 2019; 111
EPH Mahler (1797_CR30) 2015; 249
N Li (1797_CR27) 2014; 15
HM Al-Saidi (1797_CR7) 2014; 18
SF Lapachinske (1797_CR17) 2015; 247
RA Pereira (1797_CR42) 2015; 18
1797_CR31
1797_CR32
AO Maldaner (1797_CR18) 2015; 26
F Pea (1797_CR45) 2017; 177
SA Barat (1797_CR47) 1996; 742
J Broséus (1797_CR46) 2016; 262
FJM de Santana (1797_CR5) 2008; 606
P Viñas (1797_CR8) 2014; 406
JA Abin-Carriquiry (1797_CR24) 2018; 34
M Katselou (1797_CR25) 2017; 25
I Evrard (1797_CR21) 2010; 21
M Knuth (1797_CR29) 2018; 285
EG Primel (1797_CR6) 2017; 14
M Rezaee (1797_CR3) 2006; 1116
P Viñas (1797_CR10) 2015; 1376
A Jouyban (1797_CR36) 2015; 134
ED Botelho (1797_CR19) 2014; 25
O Kudlacek (1797_CR41) 2017; 83-84
R Solimini (1797_CR16) 2017; 18
G Saluti (1797_CR26) 2016; 54
References_xml – volume: 94
  start-page: 145
  year: 2014
  end-page: 151
  ident: CR35
  article-title: Rapid extraction and determination of amphetamines in human urine samples using dispersive liquid–liquid microextraction and solidification of floating organic drop followed by high performance liquid chromatography
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2014.01.044
  contributor:
    fullname: Shamsipur
– volume: 1116
  start-page: 1
  year: 2006
  end-page: 9
  ident: CR3
  article-title: Determination of organic compounds in water using dispersive liquid-liquid microextraction
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2006.03.007
  contributor:
    fullname: Berijani
– volume: 285
  start-page: 86
  year: 2018
  end-page: 92
  ident: CR29
  article-title: Analysis of cocaine adulterants in human brain in cases of drug-related death
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2018.02.001
  contributor:
    fullname: Pawlik
– volume: 26
  start-page: 1227
  issue: 6
  year: 2015
  end-page: 1231
  ident: CR18
  article-title: Brazilian Federal District cocaine chemical profiling - mass balance approach and new adulterant routinely quantified (aminopyrine)
  publication-title: J Braz Chem Soc
  doi: 10.5935/0103-5053.20150088
  contributor:
    fullname: Grobério
– volume: 742
  start-page: 157
  issue: 1–2
  year: 1996
  end-page: 162
  ident: CR47
  article-title: Cocaine and lidocaine in combination are synergistic convulsants
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(96)01004-9
  contributor:
    fullname: Abdel-Rahman
– volume: 1376
  start-page: 18
  year: 2015
  end-page: 25
  ident: CR10
  article-title: Determination of phthalate esters in cleaning and personal care products by dispersive liquid-liquid microextraction and liquid chromatography-tandem mass spectrometry
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2014.12.012
  contributor:
    fullname: Hernández-Córdoba
– volume: 1043
  start-page: 44
  year: 2017
  end-page: 62
  ident: CR2
  article-title: Green approaches in sample preparation of bioanalytical samples prior to chromatographic analysis
  publication-title: J Chromatogr B
  doi: 10.1016/j.jchromb.2016.08.040
  contributor:
    fullname: Samanidou
– volume: 1061-1062
  start-page: 382
  year: 2017
  end-page: 391
  ident: CR9
  article-title: Pharmaceutical and biomedical applications of dispersive liquid-liquid microextraction
  publication-title: J Chromatogr B Anal Technol Biomed Life Sci
  doi: 10.1016/j.jchromb.2017.07.055
  contributor:
    fullname: Khairy
– volume: 247
  start-page: 48
  year: 2015
  end-page: 53
  ident: CR17
  article-title: Analysis of cocaine and its adulterants in drugs for international trafficking seized by the Brazilian Federal Police
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2014.11.028
  contributor:
    fullname: Yonamine
– volume: 134
  start-page: 681
  year: 2015
  end-page: 689
  ident: CR36
  article-title: Determination of five antiarrhythmic drugs in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography
  publication-title: Talanta
  doi: 10.1016/j.talanta.2014.12.008
  contributor:
    fullname: Fazeli-Bakhtiyari
– volume: 104
  start-page: 798
  issue: 5
  year: 2009
  end-page: 805
  ident: CR20
  article-title: An analysis of cocaine powder in the Netherlands: content and health hazards due to adulterants
  publication-title: Addiction.
  doi: 10.1111/j.1360-0443.2009.02532.x
  contributor:
    fullname: Niesink
– volume: 25
  start-page: 765
  issue: 145
  year: 2017
  end-page: 772
  ident: CR25
  article-title: Development and validation of a GC-MS method for the determination of hydroxyzine and its active metabolite, cetirizine, in whole blood
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2017.07.059
  contributor:
    fullname: Papoutsis
– volume: 18
  start-page: 1164
  issue: 7
  year: 2015
  end-page: 1172
  ident: CR42
  article-title: Beverages consumption in Brazil: results from the first National Dietary Survey
  publication-title: Public Health Nutr
  doi: 10.1017/S1368980014001657
  contributor:
    fullname: Popkin
– volume: 58
  start-page: 32
  year: 2003
  end-page: 45
  ident: CR49
  article-title: Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
  publication-title: Cardiovasc Res
  doi: 10.1016/S0008-6363(02)00846-5
  contributor:
    fullname: Davis
– volume: 177
  start-page: 1543
  issue: 10
  year: 2017
  end-page: 1544
  ident: CR45
  article-title: β-Blockers and diltiazem combination-bear in mind the risk of heart block
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2017.4765
  contributor:
    fullname: Pea
– volume: 376
  start-page: 102
  year: 2017
  end-page: 112
  ident: CR15
  article-title: Dispersive liquid-liquid microextraction based on solidification of floating organic drop and high-performance liquid chromatography to the analysis of cocaine’s major adulterants in human urine
  publication-title: Toxicology
  doi: 10.1016/j.tox.2016.04.008
  contributor:
    fullname: de Santana
– ident: CR32
– volume: 878
  start-page: 2175
  issue: 24
  year: 2010
  end-page: 2183
  ident: CR33
  article-title: Hollow fiber-based liquid phase microextraction with factorial design optimization and gas chromatography-tandem mass spectrometry for determination of cannabinoids in human hair
  publication-title: J Chromatogr B Anal Technol Biomed Life Sci
  doi: 10.1016/j.jchromb.2010.06.005
  contributor:
    fullname: Dórea
– volume: 73
  start-page: 82
  year: 2013
  end-page: 89
  ident: CR13
  article-title: Dispersive liquid-liquid microextraction combined with capillary electrophoresis and time-of-flight mass spectrometry for urine analysis
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2012.03.036
  contributor:
    fullname: Rudaz
– volume: 54
  start-page: 1193
  issue: 7
  year: 2016
  end-page: 1200
  ident: CR26
  article-title: Flexible method for analysis of lidocaine and its metabolite in biological fluids
  publication-title: J Chromatogr Sci
  doi: 10.1093/chromsci/bmw051
  contributor:
    fullname: Galarini
– volume: 111
  start-page: 185
  year: 2019
  end-page: 196
  ident: CR1
  article-title: Green analytical chemistry: social dimension and teaching
  publication-title: Trends Anal Chem
  doi: 10.1016/j.trac.2018.10.022
  contributor:
    fullname: Płotka-Wasylka
– volume: 606
  start-page: 80
  year: 2008
  end-page: 91
  ident: CR5
  article-title: Enantioselective analysis of mirtazapine and its two major metabolites in human plasma by liquid chromatography–mass spectrometry after three-phase liquid-phase microextraction
  publication-title: Anal Chim Acta
  doi: 10.1016/j.aca.2007.10.037
  contributor:
    fullname: Bonato
– volume: 2014
  start-page: 1
  year: 2014
  end-page: 3
  ident: CR23
  article-title: Levamisole-contaminated cocaine: an emergent cause of vasculitis and skin necrosis
  publication-title: Case Rep Med
  doi: 10.1155/2014/434717
  contributor:
    fullname: Mobarakai
– volume: 15
  start-page: 90
  issue: 967
  year: 2014
  end-page: 97
  ident: CR27
  article-title: A novel micellar per aqueous liquid chromatographic method for simultaneous determination of diltiazem hydrochloride, metoprolol tartrate and isosorbide mononitrate in human serum
  publication-title: J Chromatogr B Anal Technol Biomed Life Sci
  doi: 10.1016/j.jchromb.2014.07.019
  contributor:
    fullname: Dong
– volume: 34
  start-page: 295
  year: 2018
  end-page: 304
  ident: CR24
  article-title: Identification and quantification of cocaine and active adulterants in coca-paste seized samples: useful scientific support to health care
  publication-title: Neurotox Res
  doi: 10.1007/s12640-018-9887-1
  contributor:
    fullname: Scorza
– volume: 149
  start-page: 494
  year: 2018
  end-page: 501
  ident: CR14
  article-title: Rapid and simple procedure for the determination of cathinones, amphetamine-like stimulants and other new psychoactive substances in blood and urine by GC-MS
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2017.11.024
  contributor:
    fullname: Strano
– volume: 123
  start-page: 33
  year: 2015
  end-page: 41
  ident: CR12
  article-title: High-throughput dispersive liquid/liquid microextraction (DLLME) method for the rapid determination of drugs of abuse, benzodiazepines and other psychotropic medications in blood samples by liquid chromatography–tandem mass spectrometry (LC-MS/MS) and application to forensic cases
  publication-title: Microchem J
  doi: 10.1016/j.microc.2015.05.009
  contributor:
    fullname: Strano-Rossi
– volume: 62
  start-page: 2145
  year: 1990
  end-page: 2148
  ident: CR4
  article-title: Solid phase microextraction with thermal desorption using fused silica optical fibers
  publication-title: Anal Chem
  doi: 10.1021/ac00218a019
  contributor:
    fullname: Pawliszyn
– volume: 266
  start-page: 407
  issue: 1
  year: 1993
  end-page: 416
  ident: CR43
  article-title: Effect of calcium-channel antagonists on cocaine-induced malignant arrhythmias: protection against ventricular fibrillation
  publication-title: J Pharmacol Exp Ther
  contributor:
    fullname: Billman
– volume: 406
  start-page: 2067
  issue: 8
  year: 2014
  end-page: 2099
  ident: CR8
  article-title: Dispersive liquid-liquid microextraction in food analysis. A critical review
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-013-7344-9
  contributor:
    fullname: Hernández-Córdoba
– volume: 32
  start-page: 71
  issue: 1
  year: 2011
  end-page: 77
  ident: CR50
  article-title: Fatal cocaine interactions: a review of cocaine-related deaths in Bexar County, Texas
  publication-title: Am J Forensic Med Pathol
  doi: 10.1097/PAF.0b013e3181ed79fe
  contributor:
    fullname: Hargrove
– volume: 126
  start-page: 1964
  issue: 4
  year: 2011
  end-page: 1970
  ident: CR28
  article-title: A new method based on electrospray ionisation ion mobility spectrometry (ESI-IMS) for simultaneous determination of caffeine and theophylline
  publication-title: Food Chem
  doi: 10.1016/j.foodchem.2010.12.054
  contributor:
    fullname: Javaheri
– volume: 249
  start-page: 294
  year: 2015
  end-page: 303
  ident: CR30
  article-title: Drug-related death: adulterants from cocaine preparations in lung tissue and blood
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2015.02.006
  contributor:
    fullname: Daldrup
– volume: 83-84
  start-page: 75
  year: 2017
  end-page: 81
  ident: CR41
  article-title: Cocaine adulteration
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2017.06.001
  contributor:
    fullname: Sitte
– volume: 18
  start-page: 745
  issue: 6
  year: 2014
  end-page: 761
  ident: CR7
  article-title: The recent developments in dispersive liquid-liquid microextraction for preconcentration and determination of inorganic analytes
  publication-title: J Saudi Chem Soc
  doi: 10.1016/j.jscs.2011.11.005
  contributor:
    fullname: Emara
– volume: 4
  start-page: 55
  issue: 1
  year: 2008
  end-page: 74
  ident: CR34
  article-title: Experimental design techniques for optimization of analytical methods. Part I: separation and sample preparation techniques
  publication-title: Curr Anal Chem
  doi: 10.2174/157341108783339070
  contributor:
    fullname: Careri
– volume: 18
  start-page: 524
  issue: 7
  year: 2017
  end-page: 530
  ident: CR16
  article-title: Adulteration practices of psychoactive illicit drugs: an updated review
  publication-title: Curr Pharm Biotechnol
  doi: 10.2174/1389201018666170710184531
  contributor:
    fullname: Zaami
– volume: 25
  start-page: 611
  issue: 4
  year: 2014
  end-page: 618
  ident: CR19
  article-title: Chemical profiling of cocaine seized by Brazilian Federal Police in 2009-2012: major components
  publication-title: J Braz Chem Soc
  doi: 10.5935/0103-5053.20140008
  contributor:
    fullname: Maldaner
– volume: 233
  start-page: 2879
  issue: 15–16
  year: 2016
  end-page: 2889
  ident: CR40
  article-title: Caffeine, a common active adulterant of cocaine, enhances the reinforcing effect of cocaine and its motivational value
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-016-4320-z
  contributor:
    fullname: Valentini
– volume: 6
  start-page: 2812
  year: 2014
  end-page: 2831
  ident: CR37
  article-title: Principal component analysis
  publication-title: Anal Methods
  doi: 10.1039/C3AY41907J
  contributor:
    fullname: Smilde
– ident: CR31
– volume: 14
  start-page: 1
  year: 2017
  end-page: 18
  ident: CR6
  article-title: An overview of advances in dispersive liquid-liquid microextraction for the extraction of pesticides and emerging contaminants from environmental samples
  publication-title: Trends Environ Anal Chem
  doi: 10.1016/j.teac.2017.03.001
  contributor:
    fullname: Escarrone
– volume: 257
  start-page: 307
  year: 2015
  end-page: 313
  ident: CR22
  article-title: Qualitative, quantitative and temporal study of cutting agents for cocaine and heroin over 9 years
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2015.09.014
  contributor:
    fullname: Esseiva
– volume: 262
  start-page: 73
  year: 2016
  end-page: 83
  ident: CR46
  article-title: The cutting of cocaine and heroin: a critical review
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2016.02.033
  contributor:
    fullname: Esseiva
– volume: 21
  start-page: 399
  year: 2010
  end-page: 406
  ident: CR21
  article-title: Composition, purity and perceived quality of street cocaine in France
  publication-title: Int J Drug Policy
  doi: 10.1016/j.drugpo.2010.03.004
  contributor:
    fullname: Cadet-Taïroua
– volume: 170
  start-page: 176
  year: 2017
  end-page: 182
  ident: CR38
  article-title: Occurrence of cocaine and metabolites in hospital effluent - a risk evaluation and development of a HPLC method using DLLME
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.12.019
  contributor:
    fullname: Souza
– volume: 24
  start-page: 475
  year: 2015
  end-page: 481
  ident: CR39
  article-title: Caffeine enhances and accelerates the expression of sensitization induced by coca paste indicating its relevance as a main adulterant
  publication-title: Am J Addict
  doi: 10.1111/ajad.12245
  contributor:
    fullname: Scorza
– volume: 31
  start-page: 989
  issue: 6
  year: 2013
  ident: CR44
  article-title: Safety of beta-blockers in the acute management of cocaine-associated chest pain
  publication-title: Am J Emerg Med
  doi: 10.1016/j.ajem.2013.02.022
  contributor:
    fullname: Hasan
– volume: 89
  start-page: 1363
  year: 2003
  end-page: 1372
  ident: CR48
  article-title: Drug induced QT prolongation and torsades de pointes
  publication-title: Heart
  doi: 10.1136/heart.89.11.1363
  contributor:
    fullname: Camm
– volume: 7
  start-page: 2211
  issue: 17
  year: 2015
  end-page: 2225
  ident: CR11
  article-title: Dispersive liquid-liquid microextraction: trends in the analysis of biological samples
  publication-title: Bioanalysis.
  doi: 10.4155/bio.15.141
  contributor:
    fullname: Prieto
– volume: 21
  start-page: 399
  year: 2010
  ident: 1797_CR21
  publication-title: Int J Drug Policy
  doi: 10.1016/j.drugpo.2010.03.004
  contributor:
    fullname: I Evrard
– volume: 32
  start-page: 71
  issue: 1
  year: 2011
  ident: 1797_CR50
  publication-title: Am J Forensic Med Pathol
  doi: 10.1097/PAF.0b013e3181ed79fe
  contributor:
    fullname: K Molina
– volume: 285
  start-page: 86
  year: 2018
  ident: 1797_CR29
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2018.02.001
  contributor:
    fullname: M Knuth
– volume: 1116
  start-page: 1
  year: 2006
  ident: 1797_CR3
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2006.03.007
  contributor:
    fullname: M Rezaee
– volume: 1043
  start-page: 44
  year: 2017
  ident: 1797_CR2
  publication-title: J Chromatogr B
  doi: 10.1016/j.jchromb.2016.08.040
  contributor:
    fullname: O Filippou
– volume: 18
  start-page: 1164
  issue: 7
  year: 2015
  ident: 1797_CR42
  publication-title: Public Health Nutr
  doi: 10.1017/S1368980014001657
  contributor:
    fullname: RA Pereira
– volume: 1376
  start-page: 18
  year: 2015
  ident: 1797_CR10
  publication-title: J Chromatogr A
  doi: 10.1016/j.chroma.2014.12.012
  contributor:
    fullname: P Viñas
– volume: 26
  start-page: 1227
  issue: 6
  year: 2015
  ident: 1797_CR18
  publication-title: J Braz Chem Soc
  doi: 10.5935/0103-5053.20150088
  contributor:
    fullname: AO Maldaner
– ident: 1797_CR31
– volume: 31
  start-page: 989
  issue: 6
  year: 2013
  ident: 1797_CR44
  publication-title: Am J Emerg Med
  doi: 10.1016/j.ajem.2013.02.022
  contributor:
    fullname: M Ibrahim
– volume: 177
  start-page: 1543
  issue: 10
  year: 2017
  ident: 1797_CR45
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2017.4765
  contributor:
    fullname: F Pea
– volume: 73
  start-page: 82
  year: 2013
  ident: 1797_CR13
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2012.03.036
  contributor:
    fullname: I Kohler
– volume: 62
  start-page: 2145
  year: 1990
  ident: 1797_CR4
  publication-title: Anal Chem
  doi: 10.1021/ac00218a019
  contributor:
    fullname: CL Arthur
– volume: 262
  start-page: 73
  year: 2016
  ident: 1797_CR46
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2016.02.033
  contributor:
    fullname: J Broséus
– volume: 83-84
  start-page: 75
  year: 2017
  ident: 1797_CR41
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2017.06.001
  contributor:
    fullname: O Kudlacek
– volume: 134
  start-page: 681
  year: 2015
  ident: 1797_CR36
  publication-title: Talanta
  doi: 10.1016/j.talanta.2014.12.008
  contributor:
    fullname: A Jouyban
– volume: 149
  start-page: 494
  year: 2018
  ident: 1797_CR14
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2017.11.024
  contributor:
    fullname: G Mercieca
– volume: 34
  start-page: 295
  year: 2018
  ident: 1797_CR24
  publication-title: Neurotox Res
  doi: 10.1007/s12640-018-9887-1
  contributor:
    fullname: JA Abin-Carriquiry
– volume: 89
  start-page: 1363
  year: 2003
  ident: 1797_CR48
  publication-title: Heart
  doi: 10.1136/heart.89.11.1363
  contributor:
    fullname: YG Yap
– volume: 266
  start-page: 407
  issue: 1
  year: 1993
  ident: 1797_CR43
  publication-title: J Pharmacol Exp Ther
  contributor:
    fullname: GE Billman
– volume: 123
  start-page: 33
  year: 2015
  ident: 1797_CR12
  publication-title: Microchem J
  doi: 10.1016/j.microc.2015.05.009
  contributor:
    fullname: M Fisichella
– volume: 18
  start-page: 524
  issue: 7
  year: 2017
  ident: 1797_CR16
  publication-title: Curr Pharm Biotechnol
  doi: 10.2174/1389201018666170710184531
  contributor:
    fullname: R Solimini
– volume: 15
  start-page: 90
  issue: 967
  year: 2014
  ident: 1797_CR27
  publication-title: J Chromatogr B Anal Technol Biomed Life Sci
  doi: 10.1016/j.jchromb.2014.07.019
  contributor:
    fullname: N Li
– volume: 94
  start-page: 145
  year: 2014
  ident: 1797_CR35
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2014.01.044
  contributor:
    fullname: T Ahmadi-Jouibari
– volume: 4
  start-page: 55
  issue: 1
  year: 2008
  ident: 1797_CR34
  publication-title: Curr Anal Chem
  doi: 10.2174/157341108783339070
  contributor:
    fullname: F Bianchi
– volume: 406
  start-page: 2067
  issue: 8
  year: 2014
  ident: 1797_CR8
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-013-7344-9
  contributor:
    fullname: P Viñas
– volume: 104
  start-page: 798
  issue: 5
  year: 2009
  ident: 1797_CR20
  publication-title: Addiction.
  doi: 10.1111/j.1360-0443.2009.02532.x
  contributor:
    fullname: TM Brunt
– volume: 606
  start-page: 80
  year: 2008
  ident: 1797_CR5
  publication-title: Anal Chim Acta
  doi: 10.1016/j.aca.2007.10.037
  contributor:
    fullname: FJM de Santana
– volume: 1061-1062
  start-page: 382
  year: 2017
  ident: 1797_CR9
  publication-title: J Chromatogr B Anal Technol Biomed Life Sci
  doi: 10.1016/j.jchromb.2017.07.055
  contributor:
    fullname: FR Mansour
– volume: 126
  start-page: 1964
  issue: 4
  year: 2011
  ident: 1797_CR28
  publication-title: Food Chem
  doi: 10.1016/j.foodchem.2010.12.054
  contributor:
    fullname: MT Jafari
– volume: 111
  start-page: 185
  year: 2019
  ident: 1797_CR1
  publication-title: Trends Anal Chem
  doi: 10.1016/j.trac.2018.10.022
  contributor:
    fullname: A Kurowska-Susdorf
– volume: 247
  start-page: 48
  year: 2015
  ident: 1797_CR17
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2014.11.028
  contributor:
    fullname: SF Lapachinske
– volume: 2014
  start-page: 1
  year: 2014
  ident: 1797_CR23
  publication-title: Case Rep Med
  doi: 10.1155/2014/434717
  contributor:
    fullname: O Souied
– volume: 742
  start-page: 157
  issue: 1–2
  year: 1996
  ident: 1797_CR47
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(96)01004-9
  contributor:
    fullname: SA Barat
– volume: 24
  start-page: 475
  year: 2015
  ident: 1797_CR39
  publication-title: Am J Addict
  doi: 10.1111/ajad.12245
  contributor:
    fullname: JP Prieto
– volume: 170
  start-page: 176
  year: 2017
  ident: 1797_CR38
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.12.019
  contributor:
    fullname: AF Martins
– volume: 233
  start-page: 2879
  issue: 15–16
  year: 2016
  ident: 1797_CR40
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-016-4320-z
  contributor:
    fullname: JP Prieto
– volume: 25
  start-page: 765
  issue: 145
  year: 2017
  ident: 1797_CR25
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2017.07.059
  contributor:
    fullname: M Katselou
– volume: 14
  start-page: 1
  year: 2017
  ident: 1797_CR6
  publication-title: Trends Environ Anal Chem
  doi: 10.1016/j.teac.2017.03.001
  contributor:
    fullname: EG Primel
– volume: 249
  start-page: 294
  year: 2015
  ident: 1797_CR30
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2015.02.006
  contributor:
    fullname: EPH Mahler
– volume: 18
  start-page: 745
  issue: 6
  year: 2014
  ident: 1797_CR7
  publication-title: J Saudi Chem Soc
  doi: 10.1016/j.jscs.2011.11.005
  contributor:
    fullname: HM Al-Saidi
– volume: 58
  start-page: 32
  year: 2003
  ident: 1797_CR49
  publication-title: Cardiovasc Res
  doi: 10.1016/S0008-6363(02)00846-5
  contributor:
    fullname: WS Redfern
– volume: 25
  start-page: 611
  issue: 4
  year: 2014
  ident: 1797_CR19
  publication-title: J Braz Chem Soc
  doi: 10.5935/0103-5053.20140008
  contributor:
    fullname: ED Botelho
– ident: 1797_CR32
– volume: 376
  start-page: 102
  year: 2017
  ident: 1797_CR15
  publication-title: Toxicology
  doi: 10.1016/j.tox.2016.04.008
  contributor:
    fullname: LC Sena
– volume: 54
  start-page: 1193
  issue: 7
  year: 2016
  ident: 1797_CR26
  publication-title: J Chromatogr Sci
  doi: 10.1093/chromsci/bmw051
  contributor:
    fullname: G Saluti
– volume: 878
  start-page: 2175
  issue: 24
  year: 2010
  ident: 1797_CR33
  publication-title: J Chromatogr B Anal Technol Biomed Life Sci
  doi: 10.1016/j.jchromb.2010.06.005
  contributor:
    fullname: ES Emídio
– volume: 7
  start-page: 2211
  issue: 17
  year: 2015
  ident: 1797_CR11
  publication-title: Bioanalysis.
  doi: 10.4155/bio.15.141
  contributor:
    fullname: O Zuloaga
– volume: 257
  start-page: 307
  year: 2015
  ident: 1797_CR22
  publication-title: Forensic Sci Int
  doi: 10.1016/j.forsciint.2015.09.014
  contributor:
    fullname: J Broséus
– volume: 6
  start-page: 2812
  year: 2014
  ident: 1797_CR37
  publication-title: Anal Methods
  doi: 10.1039/C3AY41907J
  contributor:
    fullname: R Bro
SSID ssj0015816
Score 2.402626
Snippet This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine...
SourceID proquest
gale
crossref
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 3447
SubjectTerms Acetanilide
Acetonitrile
Acute intoxication
Adulterants
Alkalizing
Analytical Chemistry
Biochemistry
Caffeine
Characterization and Evaluation of Materials
Chemical properties
Chemistry
Chemistry and Materials Science
Chloroform
Chromatography
Cocaine
Dependence
Design of experiments
Diltiazem
Dispersion
Drug abuse
Elution
Experimental design
Extraction (Chemistry)
Food Science
Freeze thaw cycles
Freeze-thawing
High performance liquid chromatography
Human wastes
Identification and classification
Intoxication
Ions
Laboratory Medicine
Lidocaine
Liquid chromatography
Liquid-liquid extraction
Methods
Monitoring/Environmental Analysis
pH effects
Phenacetin
Research Paper
Selectivity
Sodium chloride
Sodium phosphate
Solvents
Stability tests
Trifluoroacetic acid
Urine
SummonAdditionalLinks – databaseName: SpringerLINK - Czech Republic Consortium
  dbid: AGYKE
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LTxsxEB6VcIALpTxKWlr5gMQBFpHYjr3HiEcRSJxAgpNlr20R0W5oSA7kJ_CrmfHuJi20B06rlXbWa3vsmVl_8w3AjpDB2yJiWGJxkQvnRabpVvkYlNO96G0CyF72zq7F-Y28medxJ7B7cyKZNupZrhtZIwp-Cd6jcpVNF2BREuFXCxb7P24vTmaHB1KniqdEBU8Arm6dK_Pvt_xlj17vyn-YpVfnpMn8nH6EqyaJp0Kd3B9Mxu6gmL7ldHxPz1ZhpXZHWb_Sn0_wIZRrsHTUVIFbh-fjBi9DM8iGkeEOatE1ZYm5I4wIR8MGJUvF_hj9uw_MPTE_IApywsazn4Pfk4HPqgv7RQhAtAijKqOC2dIz4kzOHuYpDLUIK-5GQ_Soa1btDbg-Pbk6Osvq-g1ZIWRnnGEoxXMulCp6PRE1tyrPu51CK6e4sFaIiM5iCErHbuyQ0hSdwsrAtcydiMLxTWiVwzJsAfOoQCI6tBIe5VzuOOcq9_wwRBTRvA17zSyah4qmw8wImdP4Ghxfk8bXTNuwSxNtaA1Td22dioBtERuW6UudYyCKoWIbthtdMPXifjSpBDrxqco2fK70Y9YoR_-VK_qg_Way54L__6Iv73v8Kyx3k76Q2mxDazyahG_oHI3d93oxvAChfwlO
  priority: 102
  providerName: Springer Nature
Title Determination of cocaine adulterants in human urine by dispersive liquid-liquid microextraction and high-performance liquid chromatography
URI https://link.springer.com/article/10.1007/s00216-019-01797-z
https://www.ncbi.nlm.nih.gov/pubmed/31123783
https://www.proquest.com/docview/2229509135
Volume 411
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LbxMxEB71cYALgvIKlMgHJA50VXbtjb0nFErSqkgVQkRKT5a9tkUk2KRpemh_Qn81M15vUirR02pXGtnrzx7P2DPfALwXpXemDuiWGFzkwjqRKXqVLnhp1SA4EwNkzwYnE3E6LafpwO0yhVV2OjEqajev6Yz8MNadJhLL8vPiIqOqUXS7mkpobMNuTkx4lCk-Pl7fIpQqlj4lTniK5CpS0kxMnaPNjXxpihaSlcxu_tmY7qvnO_vTvQvTuA-Nn8KTZECyYYv4M9jyzR48Ourqtj2H269dhAuNOZsHhjoP_X_PIteGX1LkC5s1LJbnY3Ta7pm9Zm5GpOEUzc5-zy6uZi5rH-wPxeyhDl-2ORDMNI4Ry3G22CQdJBFW_1rO0QZOPNgvYDIe_Tw6yVLFhawWZb7K0PnhFRdS1oOBCIobWVVFXitpJRfGCBHQvPNeqlCEnGCu89qUnquysiIIy1_CTjNv_GtgDiEXwaJedyhnK8s5l5Xjn3xAEcV78LEbbr1oiTX0mkI5gqMRHB3B0Tc9-ECIaFp19LsmJQ9gW8RfpYelqtB1ROeuB_sdaDotx0u9mTw9eNUCuW6Uo8XJJXXooEN2I_j_Hr15uJ238LiIk4vm2D7srJZX_h2aLyvbh205lf04U_uwOzw-_zbC55fR2fcf-HVSDP8Ci0H0Yw
link.rule.ids 315,786,790,12083,12792,21416,27955,27956,31752,33406,33777,41114,41556,42183,42625,43343,43633,43838,52144,52267,74100,74390,74657
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB7xOMClaoHSpbT4gMSBRpC1s3ZOFaJFy_ME0t4sO7bFSm12WZYD_AR-NTOOs9siwSnKwbKTbzwPe-YbgF1ReGeqgGGJwU0urBOZolfpgpdW9YIzMUH2qte_EWeDYpAO3O5TWmWrE6OidqOKzsgPYt9pIrEsfo7vMuoaRberqYXGIiwLzgXJuRzMAq68ULH1KXHCUyZXNxXNxNI5Mm4US1O2kCxl9vSfYXqtnv-xT68uTKMdOvkIH5IDyY4axD_Bgq_XYOW47du2Ds-_2gwX-udsFBjqPIz_PYtcG35CmS9sWLPYno_Rabtn9pG5IZGGUzY7-zO8exi6rHmwv5Szhzp80tRAMFM7RizH2XhedJCGsOp2MkIfOPFgb8DNye_r436WOi5klSjyaYbBDy-5kLLq9URQ3Miy7OaVklZyYYwQAd0776UK3ZATzFVemcJzVZRWBGH5Z1iqR7X_Aswh5CJY1OsOx9nScs5l6fihDzhE8Q7st79bjxtiDT2jUI7gaARHR3D0Uwf2CBFNu44-16TiAZyL-Kv0UaFKDB0xuOvAdguaTtvxXs-FpwObDZCzSTl6nFzSgn60yM4Hvr2irffn2YGV_vXlhb44vTr_CqvdKGgkb9uwNJ08-G_oykzt9yivL2rp8k0
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NTxsxEB0VkIBLBQXatHz4gMQBVpDYG3tPFQJSaCvEASRulr22RaR280E4wE_or-6M15sAEpyiPVje-I3HM-s3bwB2Re6dKQOmJQY3ubBOZIoepQteWtUNzkSC7GX3_Eb8vM1vE__pPtEqG58YHbUblPSN_DD2nSYRy_wwJFrE1Wnv-3CUUQcpumlN7TTmYIGCbGrjoHo_pjcKuYptUEkfnlhdnVRAE8vo6KCjvJqYQ7KQ2dOLQ-q1q352Vr26PI1nUm8FPqZgkh3X6K_CB199gqWTpofbGvw7bdgutP5sEBj6P4OBJYu6G35MLBjWr1hs1cfoy7tn9pG5PgmIE7Od_emPHvouq3_YX-Lv4aKM63oIZirHSPE4G84KENIQVt6NBxgPJ03sdbjpnV2fnGep-0JWirw9yTAR4gUXUpbdrgiKG1kUnXappJVcGCNEwFDPe6lCJ7QJ8rJdmtxzlRdWBGH5BsxXg8p_AeYQfhEs-niH42xhOeeycPzIBxyieAv2m-XWw1pkQ0_llCM4GsHRERz91II9QkTTDqS_a1IhAc5FWlb6OFcFppGY6LVgswFNp615r2eG1ILPNZDTSTlGn1zSCx00yM4Gvv1GX9-fZwcW0VT174vLX99guRPtjMxtE-Yn4we_hVHNxG5Hc_0Pwdz2gg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Determination+of+cocaine+adulterants+in+human+urine+by+dispersive+liquid-liquid+microextraction+and+high-performance+liquid+chromatography&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.au=da+Silva%2C+Pedro+Rafael&rft.au=La%C3%ADs+Cristina+Santana+Sena&rft.au=Rubens+Pedro+Lorena+Silva&rft.au=Danielle+Cristine+Almeida+Silva+de+Santana&rft.date=2019-06-01&rft.pub=Springer+Nature+B.V&rft.issn=1618-2642&rft.eissn=1618-2650&rft.volume=411&rft.issue=16&rft.spage=3447&rft.epage=3461&rft_id=info:doi/10.1007%2Fs00216-019-01797-z&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1618-2642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1618-2642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1618-2642&client=summon