Bacterial Peptidoglycan-Associated Lipoprotein: A Naturally Occurring Toll-Like Receptor 2 Agonist That Is Shed into Serum and Has Synergy with Lipopolysaccharide

• Published in: The Journal of infectious diseases Vol. 191; no. 6; pp. 939 - 948
• Main Authors: Liang, Michael D., Bagchi, Aranya, Warren, H. Shaw, Tehan, Megan M., Trigilio, James A., Beasley-Topliffe, Laura K., Tesini, Brenda L., Lazzaroni, Jean-Claude, Fenton, Matthew J., Hellman, Judith
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.03.2005; University of Chicago Press; Oxford University Press
• Subjects: Agonists; Animals; Bacteria; Bacterial Outer Membrane Proteins - blood; Bacterial Outer Membrane Proteins - immunology; Bacteriology; Biological and medical sciences; Cell Line; Cytokines; Drug Synergism; Escherichia coli; Escherichia coli - immunology; Escherichia coli K12 - immunology; Escherichia coli Proteins; Fundamental and applied biological sciences. Psychology; Humans; Infectious diseases; Lipopolysaccharides; Lipopolysaccharides - immunology; Lipoproteins; Lipoproteins - blood; Lipoproteins - immunology; Macrophage Activation; Macrophages; Macrophages, Peritoneal - immunology; Medical sciences; Membrane Glycoproteins - agonists; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Microbiology; Miscellaneous; Peptidoglycan - blood; Peptidoglycan - immunology; Receptors, Cell Surface - agonists; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Sepsis; Sepsis - physiopathology; Toll like receptors; Toll-Like Receptor 2; Transfection; Infection; Peptidoglycan; Microbiology; Lipopolysaccharide; Bacteria; Serum; Toll like receptor; Lipoprotein

Sepsis is initiated by interactions between microbial products and host inflammatory cells. Toll-like receptors (TLRs) are central innate immune mediators of sepsis that recognize different components of microorganisms. Peptidoglycan-associated lipoprotein (PAL) is a ubiquitous gram-negative bacteri...