Sex hormone levels are not associated with progression of renal disease in male patients with T2DM

• Published in: Diabetes & metabolism Vol. 43; no. 2; pp. 140 - 145
• Main Authors: Feigerlová, E, Saulnier, P.-J, Gourdy, P, Roussel, R, Halimi, J.-M, Gand, E, Dardari, D, Guerci, B, Sosner, P, Marre, M, Zaoui, P, Ragot, S, Hadjadj, S
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.04.2017; OMICS International
• Subjects: Aged; Aromatase index; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetic Nephropathies - blood; Diabetic nephropathy; Disease Progression; Endocrinology & Metabolism; Estradiol; Estradiol - blood; Human health and pathology; Humans; Internal Medicine; Life Sciences; Male; Middle Aged; Prospective Studies; Sex Hormone-Binding Globulin - metabolism; Testosterone; Testosterone - blood; Type 2 diabetes; Type 2 diabetes; ESRD; estimated glomerular filtration rate; HRO; sex hormone-binding globulin; urinary albumin excretion; Estradiol; E2; total estradiol; cfT; T; urinary albumin concentration; RRFD; Diabetic nephropathy; total testosterone; cfE2; estrogen receptor α; Aromatase index; hard renal outcome; eGFR; ERα; calculated free testosterone; end-stage renal disease; uACR; calculated free estradiol; rapid renal function decline; Testosterone; urinary albumin-to-creatinine ratio; UAC; UAE; SRFD; SHBG; slow renal function decline

Abstract Background Greater renal function decline (RFD) in type 2 diabetes (T2DM) has been suggested in men compared with women, and imbalances in estrogen/androgen levels have been associated with cardiovascular disease mortality in elderly men, but it remains unclear whether sex hormone disequili...