Complex reactions catalyzed by cytochrome P450 enzymes

• Published in: Biochimica et biophysica acta Vol. 1770; no. 3; pp. 314 - 329
• Main Authors: Isin, Emre M., Guengerich, F. Peter
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2007
• Subjects: Animals; Bioactivation; Catalysis; Cytochrome P-450 Enzyme System - chemistry; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Dimerization; Humans; Hydroxylation; Metabolism of drugs; Mixed Function Oxygenases - metabolism; Oxidation reactions; Oxidation-Reduction; Rearrangement reactions; Substrate Specificity; Oxidation reactions; Cytochrome P450; Bioactivation; Metabolism of drugs; Rearrangement reactions

Cytochrome P450 (P450) enzymes are some of the most versatile redox proteins known. The basic P450 reactions include C-hydroxylation, heteroatom oxygenation, heteroatom release (dealkylation), and epoxide formation. Mechanistic explanations for these reactions have been advanced. A number of more co...