The role of heat shock proteins (HSPs) in type 2 diabetes mellitus pathophysiology
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitocho...
Saved in:
| Published in | Journal of diabetes and its complications Vol. 37; no. 11; p. 108564 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.11.2023
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Heat shock proteins (HSPs) are a group of highly conserved proteins that have a crucial role in chaperoning damaged and misfolded proteins to avoid disruption of cellular homeostasis under stress conditions. To do this, HSPs interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. Therefore, HSP dysfunction, e.g. HSP70, may lead to disruption of the pathways responsible for insulin secretion and uptake. Consistently, the altered expression of other HSPs and genetic polymorphisms in HSP-producing genes in diabetic subjects has made HSPs hot research in T2DM. This paper provides a comprehensive overview of the role of different HSPs in T2DM pathogenesis, affected cellular pathways, and the potential therapeutic strategies targeting HSPs in T2DM.
•The altered expression of HSPs in T2DM holds great potential to investigate their role in disease pathogenesis and their applicability as a target in clinical approaches. |
|---|---|
| AbstractList | Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Heat shock proteins (HSPs) are a group of highly conserved proteins that have a crucial role in chaperoning damaged and misfolded proteins to avoid disruption of cellular homeostasis under stress conditions. To do this, HSPs interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. Therefore, HSP dysfunction, e.g. HSP70, may lead to disruption of the pathways responsible for insulin secretion and uptake. Consistently, the altered expression of other HSPs and genetic polymorphisms in HSP-producing genes in diabetic subjects has made HSPs hot research in T2DM. This paper provides a comprehensive overview of the role of different HSPs in T2DM pathogenesis, affected cellular pathways, and the potential therapeutic strategies targeting HSPs in T2DM. Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Heat shock proteins (HSPs) are a group of highly conserved proteins that have a crucial role in chaperoning damaged and misfolded proteins to avoid disruption of cellular homeostasis under stress conditions. To do this, HSPs interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. Therefore, HSP dysfunction, e.g. HSP70, may lead to disruption of the pathways responsible for insulin secretion and uptake. Consistently, the altered expression of other HSPs and genetic polymorphisms in HSP-producing genes in diabetic subjects has made HSPs hot research in T2DM. This paper provides a comprehensive overview of the role of different HSPs in T2DM pathogenesis, affected cellular pathways, and the potential therapeutic strategies targeting HSPs in T2DM. •The altered expression of HSPs in T2DM holds great potential to investigate their role in disease pathogenesis and their applicability as a target in clinical approaches. Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Heat shock proteins (HSPs) are a group of highly conserved proteins that have a crucial role in chaperoning damaged and misfolded proteins to avoid disruption of cellular homeostasis under stress conditions. To do this, HSPs interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. Therefore, HSP dysfunction, e.g. HSP70, may lead to disruption of the pathways responsible for insulin secretion and uptake. Consistently, the altered expression of other HSPs and genetic polymorphisms in HSP-producing genes in diabetic subjects has made HSPs hot research in T2DM. This paper provides a comprehensive overview of the role of different HSPs in T2DM pathogenesis, affected cellular pathways, and the potential therapeutic strategies targeting HSPs in T2DM.Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Heat shock proteins (HSPs) are a group of highly conserved proteins that have a crucial role in chaperoning damaged and misfolded proteins to avoid disruption of cellular homeostasis under stress conditions. To do this, HSPs interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. Therefore, HSP dysfunction, e.g. HSP70, may lead to disruption of the pathways responsible for insulin secretion and uptake. Consistently, the altered expression of other HSPs and genetic polymorphisms in HSP-producing genes in diabetic subjects has made HSPs hot research in T2DM. This paper provides a comprehensive overview of the role of different HSPs in T2DM pathogenesis, affected cellular pathways, and the potential therapeutic strategies targeting HSPs in T2DM. |
| ArticleNumber | 108564 |
| Author | Elahi, Reza Rezakhani, Negin Esmaeilzadeh, Abdolreza Mohammadi, Vahid |
| Author_xml | – sequence: 1 givenname: Abdolreza surname: Esmaeilzadeh fullname: Esmaeilzadeh, Abdolreza email: A46reza@zums.ac.ir organization: Department of Immunology, Zanjan University of Medical Sciences, Zanjan, Iran – sequence: 2 givenname: Vahid surname: Mohammadi fullname: Mohammadi, Vahid organization: School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran – sequence: 3 givenname: Reza surname: Elahi fullname: Elahi, Reza organization: School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran – sequence: 4 givenname: Negin surname: Rezakhani fullname: Rezakhani, Negin organization: School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37852076$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1q3TAQhUVJaH7aVwiCbtKFbyRbkmUohRLaphBIaFPoTsjyqJZjW64kF_z2VbhJF9lkNcPwnZnDnBN0MPsZEDqjZEcJFRfDbuicNn5adiUpqzyUXLBX6JjKuiqYIL8Ock-4KGRd1kfoJMaBECI4p6_RUVVLXpJaHKPvdz3g4EfA3uIedMKx9-YeL8EncHPE51c_buN77GactgVwifPZFhJEPME4urRGvOjU-6XfovOj_729QYdWjxHePtZT9PPL57vLq-L65uu3y0_XhWGcpkIaJkxrrRTUClkRDWUliSwtkUDaRpCq6bp8irO2aVtLtWbAGgrWEGtB2-oUne_3Zq9_VohJTS6abErP4NeoSlk3jNQVIxl99wwd_Brm7C5TknNei5pn6uyRWtsJOrUEN-mwqadvZUDsARN8jAHsf4QS9RCLGtRTLOohFrWPJQs_PBMal3Ryfk5Bu_Fl-ce9HPI7_zoIyoxudkaP97CpzruXFvwDv8ar5Q |
| CitedBy_id | crossref_primary_10_1016_j_molimm_2024_03_009 crossref_primary_10_1007_s12015_023_10668_1 crossref_primary_10_1186_s40538_024_00726_2 crossref_primary_10_1002_pca_3477 |
| Cites_doi | 10.1016/j.arr.2021.101313 10.1097/MCO.0000000000000183 10.1093/gerona/glu119 10.1007/s12192-017-0767-z 10.4103/1319-2442.292312 10.1186/s12964-020-00546-5 10.2337/db21-0173 10.1155/2012/671673 10.1136/bmjdrc-2020-002057 10.1016/j.gene.2012.01.085 10.1684/ejd.2011.1530 10.1210/en.2008-0732 10.2337/db22-245-LB 10.1002/mgg3.1073 10.1007/s12192-012-0336-4 10.1007/s12192-018-0903-4 10.1007/s11892-019-1196-4 10.1016/j.exger.2017.04.005 10.1016/j.bbamcr.2016.09.012 10.1016/j.diabres.2021.109119 10.1186/1472-6823-8-3 10.2337/db13-0665 10.1096/fj.08-124602 10.7150/thno.36505 10.1016/j.cmet.2006.07.007 10.2337/diabetes.54.4.1074 10.1016/j.molmet.2021.101276 10.1371/journal.pbio.1000410 10.1210/en.2013-1667 10.1155/2014/386351 10.1128/MCB.00189-13 10.1016/j.bbrc.2012.12.029 10.1038/337655a0 10.2741/1736 10.1074/jbc.M509497200 10.1007/s12192-013-0435-x 10.1038/s41598-018-25404-w 10.1016/S1262-3636(07)70104-0 10.1016/j.jprot.2014.11.010 10.1073/pnas.1719969115 10.1074/jbc.M206525200 10.1139/cjpp-2017-0394 10.1017/S000711451100225X 10.1074/jbc.M608985200 10.1042/BJ20100434 10.1007/s12192-017-0835-4 10.1016/j.celrep.2020.01.043 10.1038/srep14448 10.2337/diab.40.11.1418 10.1210/jc.2014-1425 10.1513/pats.201008-055MS 10.1007/s12192-011-0281-7 10.1271/bbb.90147 10.1172/JCI37007 10.1016/j.molmet.2016.12.001 10.1016/j.bbadis.2018.08.034 10.1155/2015/249205 10.1042/CS20130678 10.1186/s12872-020-01456-7 10.1093/gerona/gls008 10.1016/j.jbc.2021.101368 10.1007/s12192-022-01288-8 10.1152/jappl.2000.89.3.1055 10.1016/j.biochi.2018.09.011 10.1016/j.exger.2018.07.014 10.1186/s12986-018-0242-6 10.2337/db13-0967 10.1021/pr800675k 10.1016/j.jmb.2020.02.003 10.1152/ajpendo.00215.2018 10.1379/1466-1268(1996)001<0097:DOTHSR>2.3.CO;2 10.1007/s12192-010-0204-z 10.1113/JP276559 10.1007/s00421-005-0084-6 10.1155/2010/453892 10.1101/sqb.2012.76.010637 10.3389/fcell.2020.00595 10.1016/j.febslet.2006.03.043 10.18632/oncotarget.8604 10.1074/jbc.M411860200 10.1002/iub.1370 10.1155/2017/8379327 10.1038/nrm2327 10.7554/eLife.71862 10.3390/jcm7080187 10.2337/db06-S002 10.1074/jbc.M111.331264 10.3389/fendo.2018.00423 10.1074/jbc.M116.767277 10.3390/ijms21176275 10.3390/ijms21218204 10.2337/db13-1751 10.1152/ajpregu.00581.2007 10.1139/O07-154 10.1016/j.tem.2010.08.005 10.1179/1743132815Y.0000000054 10.1016/j.lfs.2019.04.022 10.1098/rstb.2016.0529 10.1074/jbc.M207485200 10.1007/BF00218042 10.1007/s00580-012-1547-x 10.1007/s00125-006-0590-z 10.1172/JCI67615 10.15407/fz61.01.010 10.2337/db10-1574 10.1530/EJE-20-0636 10.1080/23328940.2017.1288688 10.1530/JME-19-0207 10.4239/wjd.v5.i6.747 10.2147/DMSO.S100074 10.1007/s11906-015-0615-4 10.1038/nrm.2017.73 10.1007/s12192-018-0942-x 10.1152/japplphysiol.00407.2018 10.1186/s12902-020-00653-x 10.1152/japplphysiol.00383.2018 10.1136/bmjdrc-2021-002579 10.1111/j.1582-4934.2006.tb00294.x 10.1309/LM1LE9TNGIJFD7PS 10.1379/CSC-184R.1 10.1007/s12192-008-0084-7 10.1007/s00592-016-0852-2 10.3390/biom5010194 10.1097/MD.0000000000026879 10.1016/j.jdiacomp.2015.01.007 10.1007/s12192-016-0703-7 10.1073/pnas.252341799 10.2337/db14-1357 10.1016/j.bbamcr.2015.09.009 10.1016/S0092-8674(00)80294-9 10.1111/bph.13209 10.12703/r/10-72 10.1371/journal.pone.0069217 10.1002/iub.1645 10.1038/s41467-020-16991-2 10.1073/pnas.0705799105 10.2337/diabetes.52.1.102 |
| ContentType | Journal Article |
| Copyright | 2023 Copyright © 2023. Published by Elsevier Inc. Copyright Elsevier Limited Nov 2023 |
| Copyright_xml | – notice: 2023 – notice: Copyright © 2023. Published by Elsevier Inc. – notice: Copyright Elsevier Limited Nov 2023 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 88E 8AO 8FI 8FJ 8FK 8G5 ABUWG AFKRA AN0 ASE AZQEC BENPR CCPQU DWQXO FPQ FYUFA GHDGH GNUQQ GUQSH K6X K9- K9. KB0 M0R M0S M1P M2O MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI Q9U 7X8 |
| DOI | 10.1016/j.jdiacomp.2023.108564 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central British Nursing Database (Proquest) British Nursing Index ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central British Nursing Index (BNI) (1985 to Present) Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library British Nursing Index Consumer Health Database (Alumni Edition) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Consumer Health Database ProQuest Health & Medical Collection Proquest Medical Database ProQuest Research Library Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text British Nursing Index ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1873-460X |
| ExternalDocumentID | 37852076 10_1016_j_jdiacomp_2023_108564 S1056872723001629 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29K 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 7RV 7X7 88E 8AO 8FI 8FJ 8G5 8P~ 9JM AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABGSF ABJNI ABMAC ABMZM ABUDA ABUWG ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADUVX AEBSH AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFKRA AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AHMBA AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AN0 ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN AZQEC BENPR BKEYQ BKNYI BKOJK BLXMC BNPGV BNQBC BPHCQ BVXVI CCPQU CS3 D-I DU5 DWQXO EBS EFJIC EFKBS EJD EMOBN EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-2 G-Q GBLVA GNUQQ GUQSH HDZ HMCUK HMK HMO HVGLF HZ~ IHE J1W K-O K9- KOM L7B LZ1 M0R M1P M29 M2O M41 MO0 N9A NAPCQ O-L O9- OAUVE OB0 ON- OZT P-8 P-9 P2P PC. PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSU SSZ SV3 T5K UKHRP WOW WUQ Z5R ~G- AAYXX AFCTW AGRNS ALIPV CITATION RIG AACTN CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK ASE FPQ K6X K9. MBDVC PKEHL PQEST PQUKI Q9U 7X8 |
| ID | FETCH-LOGICAL-c451t-8c46cbff861f6830ae238082f08e0b96039ddabe54b9bbf1aa4e491efc0ffeaf3 |
| IEDL.DBID | 7X7 |
| ISSN | 1056-8727 1873-460X |
| IngestDate | Thu Jul 10 18:07:50 EDT 2025 Sat Aug 23 14:27:07 EDT 2025 Thu Apr 03 06:54:13 EDT 2025 Tue Jul 01 00:51:08 EDT 2025 Thu Apr 24 22:54:26 EDT 2025 Tue Aug 26 16:32:46 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | HSP70 Type 2 diabetes mellitus Insulin Heat shock protein |
| Language | English |
| License | Copyright © 2023. Published by Elsevier Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c451t-8c46cbff861f6830ae238082f08e0b96039ddabe54b9bbf1aa4e491efc0ffeaf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| PMID | 37852076 |
| PQID | 2885557675 |
| PQPubID | 1226340 |
| ParticipantIDs | proquest_miscellaneous_2879407340 proquest_journals_2885557675 pubmed_primary_37852076 crossref_primary_10_1016_j_jdiacomp_2023_108564 crossref_citationtrail_10_1016_j_jdiacomp_2023_108564 elsevier_clinicalkey_doi_10_1016_j_jdiacomp_2023_108564 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | November 2023 2023-11-00 20231101 |
| PublicationDateYYYYMMDD | 2023-11-01 |
| PublicationDate_xml | – month: 11 year: 2023 text: November 2023 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Philadelphia |
| PublicationTitle | Journal of diabetes and its complications |
| PublicationTitleAlternate | J Diabetes Complications |
| PublicationYear | 2023 |
| Publisher | Elsevier Inc Elsevier Limited |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier Limited |
| References | Ritossa (bb0050) 1996; 1 Abubaker, Tiss, Abu-Farha, Al-Ghimlas, Al-Khairi, Baturcam (bb0055) 2013; 8 Tubbs, Theurey, Vial, Bendridi, Bravard, Chauvin (bb0235) 2014; 63 Elshahed, Shaker (bb0565) 2020; 31 Taherian, Krone, Ovsenek (bb0305) 2008; 86 Kravats, Hoskins, Reidy, Johnson, Doyle, Genest (bb0075) 2018; 115 Dorcely, Katz, Jagannathan, Chiang, Oluwadare, Goldberg (bb0520) 2017; 10 Krause, Ludwig, Heck, Takahashi (bb0665) 2015; 18 Lei, Venkatakrishnan, Yu, Kazlauskas (bb0735) 2007; 282 Kuan, Hashidume, Shibata, Uchida, Shimizu, Inoue (bb0320) 2017; 292 Nakhjavani, Morteza, Asgarani, Khalilzadeh, Ghazizadeh, Bathaie (bb0125) 2012; 498 Hauffe, Rath, Schell, Ritter, Kappert, Deubel (bb0340) 2021; 53 Sakamoto, Mashima, Yamamoto, Tsuruo (bb0500) 2002; 277 Kammoun, Chabanon, Hainault, Luquet, Magnan, Koike (bb0245) 2009; 119 Hatle, Gummadidala, Navasa, Bernardo, Dodge, Silverstrim (bb0280) 2013; 33 Molina, Ferder, Manucha (bb0190) 2016; 18 Fakhruddin, Alanazi, Jackson (bb0105) 2017; 2017 Nakhjavani, Morteza, Khajeali, Esteghamati, Khalilzadeh, Asgarani (bb0140) 2010; 15 Magalhães, Nogueira, Kaneko (bb0080) 2012; 22 Tiwary, Nandwani, Khan, Datta (bb0430) 2021; 297 Ota, Wang (bb0445) 2012; 287 Christensen, Gannon (bb0380) 2019; 19 Tzeng, Hohmeier, Lorenzo (bb0460) 2022; 71 Tsuzuki, Kobayashi, Yoshihara, Kakigi, Ichinoseki-Sekine, Naito (bb0630) 2017; 22 Gober, Wales, Aurelian (bb0385) 2005; 10 Febbraio, Koukoulas (bb0655) 2000; 89 Abu-Farha, Cherian, Al-Khairi, Tiss, Khadir, Kavalakatt (bb0180) 2015; 5 Kim, Kim, Lee, Yang, Park, Kim (bb0490) 2006; 580 Kitano, Kondo, Matsuyama, Ono, Goto, Takaki (bb0200) 2019; 316 Han, Song, Kim, Kodali, Pottekat, Wang (bb0475) 2015; 64 Moniruzzaman, Ahmed, Huq, All Mahmud, Begum, Mahzabin Amin (bb0580) 2020; 8 Venojärvi, Aunola, Puhke, Marniemi, Hämäläinen, Halonen (bb0650) 2008; 8 Hafen, Preece, Sorensen, Hancock, Hyldahl (bb0690) 2018; 125 Kijima, Prince, Tigue, Yim, Schwartz, Beebe (bb0300) 2018; 8 Sharma, Bharti, Ojha, Bhatia, Kumar, Ray (bb0370) 2011; 106 Seibert, Anklam, Costa-Beber, Sulzbacher, Sulzbacher, Sangiovo (bb0585) 2022; 27 Rowles, Keane, Gomes Heck, Cruzat, Verdile, Newsholme (bb0035) 2020; 21 Cherian, Al-Khairi, Sriraman, Al-Enezi, Al-Sultan, AlOtaibi (bb0155) 2018; 9 Yan, Frank, Korth, Sopher, Novoa, Ron (bb0470) 2002; 99 Verma, Verma, Chaphalkar, Chakraborty (bb0065) 2021; 10 Read, Schröder (bb0410) 2021; 10 Calderwood, Gong, Murshid (bb0085) 2016 Drew, Ribas, Le, Henstridge, Phun, Zhou (bb0225) 2014; 63 Singh, Agrawal, Gupta, Mohan, Chaturvedi, Singh (bb0550) 2015; 29 Jing, Sundararajan, Majumdar, Hazarika, Fowler, Szeto (bb0295) 2018; 15 Kavanagh, Wylie, Chavanne, Jorgensen, Voruganti, Comuzzie (bb0605) 2012; 67 Farmer, Williams, Novikova, Ramachandran, Rawal, Blagg (bb0720) 2012; 2012 Anderson (bb0440) 2006; 10 Yuan, Dunn, Martinus (bb0135) 2011; 16 Bruxel, Tavares, Zavarize Neto, de Souza, Schroeder, Bock (bb0675) 2019; 156 Kavanagh, Zhang, Wagner (bb0185) 2009; 14 Mahmoud, Haines, Dashti, El-Shazly, Al-Najjar (bb0150) 2018; 23 Faulkner, Jackson, Fatania, Leicht (bb0680) 2017; 4 Silverstein, Ordanes, Wylie, Files, Milligan, Presley (bb0670) 2015; 70 de Lemos Muller, Rech, Botton, Schroeder, Bock, Farinha (bb0640) 2018; 111 Venojärvi, Korkmaz, Aunola, Hällsten, Virtanen, Marniemi (bb0170) 2014; 2014 Sun, Saeedi, Karuranga, Pinkepank, Ogurtsova, Duncan (bb0010) 2022; 183 Dodd, Hain, Senf, Judge (bb0365) 2009; 23 Gjøvaag, Vikne, Dahl (bb0660) 2006; 96 Brunt, Wiedenfeld-Needham, Comrada, Minson (bb0685) 2018; 596 Henstridge, Bruce, Drew, Tory, Kolonics, Estevez (bb0220) 2014; 63 Ibrahim, Abdelmalek, Elfiky (bb0240) 2019; 226 Muoio, Newgard (bb0030) 2008; 9 Wang, Shi, Lu, Zhang, Yang, Wen (bb0545) 2020; 20 Ding, Meng, Dong, Zhang, Zhou, Tan (bb0540) 2022; 10 Zeng, Wang, Bai, Zhou, Li, Ren (bb0705) 2015; 172 Clark, Jones, de Koning, Hansen, Matthews (bb0115) 2001; 50(suppl_1):S169-S Gomez-Pastor, Burchfiel, Thiele (bb0060) 2018; 19 Zouari Bouassida, Chouchane, Jellouli, Chérif, Haddad, Gabbouj (bb0570) 2004; 30 Lytrivi, Senée, Salpea, Fantuzzi, Philippi, Abdulkarim (bb0485) 2021; 184 Kleinridders, Lauritzen, Ussar, Christensen, Mori, Bross (bb0335) 2013; 123 Barbier-Torres, Fortner, Iruzubieta, Delgado, Giddings, Chen (bb0285) 2020; 11 Guan, Sheu, Yang, Chan, Wu, Yang (bb0495) 2016; 7 Nakatani, Kaneto, Kawamori, Yoshiuchi, Hatazaki, Matsuoka (bb0730) 2005; 280 Gonzalez, Garrie, Turner (bb0110) 2018; 1864 Alemi, Khaloo, Rabizadeh, Mansournia, Mirmiranpour, Salehi (bb0260) 2019; 24 Gupta, Deepti, Deegan, Lisbona, Hetz, Samali (bb0395) 2010; 8 Sun, Liao, Qu, Xiao, Hou, Chen (bb0275) 2020; 30 López-Jaramillo, Velandia-Carrillo, Gómez-Arbeláez, Aldana-Campos (bb0020) 2014; 5 Yang, Zhang, Xu, Deng, Liu, Li (bb0450) 2016; 53 Molanouri Shamsi, Mahdavi, Quinn, Gharakhanlou, Isanegad (bb0635) 2016; 21 Archer, Von Schulze, Geiger (bb0610) 2018; 373 Singh, Kølvraa, Bross, Jensen, Gregersen, Tan (bb0590) 2006; 11 Margulis, Sandler, Eizirik, Welsh, Welsh (bb0615) 1991; 40 Kaneto, Katakami, Matsuhisa, Matsuoka (bb0095) 2010; 2010 Zheng, Zhang, Liu, Jin, Dai, Cheng (bb0315) 2019; 9 Yang, Khosravi-Far, Chang, Baltimore (bb0505) 1997; 89 ElGemei, Shaheen, Abu Khalil (bb0600) 2013; 22 Butler, Janson, Bonner-Weir, Ritzel, Rizza, Butler (bb0375) 2003; 52 Ye, Li (bb0455) 2009; 73 Ogura, Naito, Akin, Ichinoseki-Sekine, Kurosaka, Kakigi (bb0625) 2008; 294 Cavener, Gupta, McGrath (bb0420) 2010; 21 Stankiewicz, Lachapelle, Foo, Radicioni, Mosser (bb0390) 2005; 280 Reddy, Jakhotia, Reddy, Reddy (bb0175) 2015; 67 Atkin, Moin, Al-Qaissi, Sathyapalan, Atkin, Butler (bb0145) 2021; 9 Ladiges, Knoblaugh, Morton, Korth, Sopher, Baskin (bb0480) 2005; 54 Krause, Keane, Rodrigues-Krause, Crognale, Egan, De Vito (bb0255) 2014; 126 Huang, Wang, Wang, Lin, Luo, Yang (bb0350) 2022; 23 Chung, Nguyen, Henstridge, Holmes, Chan, Mesa (bb0165) 2008; 105 Ma, Xu, Yin, Zheng, Liu, Wang (bb0130) 2021; 100 Hickey, Bradley, Skea, Middleditch, Buchanan, Phillips (bb0405) 2009; 8 Zhao, Luo, Gao, Fu, Li, Shao (bb0425) 2022; 71 Morino, Petersen, Shulman (bb0215) 2006; 55 Suppl 2 Long, Yang, Wang, Han, Peng, Yan (bb0525) 2020; 20 Lee, Gao, Kosinski, Elliman, Hughes, Gromada (bb0310) 2013; 430 Bouchecareilh, Balch (bb0045) 2011; 8 Njemini, Forti, Mets, Van Roie, Coudyzer, Beyer (bb0645) 2017; 93 Brzozowska, Havula, Allen, Cox (bb0015) 2019 Alderson, Ying, Bax, Benesch, Baldwin (bb0070) 2020; 432 Zubair, Ahmad (bb0555) 2018; 7 Dimitrovska, Dervisevik, Cipanovska, Gerazova, Dinevska-Kjovkarovska, Miova (bb0700) 2018; 96 Edlitz, Segal (bb0515) 2022; 11 Diane, Abunada, Khattab, Moin, Butler, Dehbi (bb0270) 2021; 67 Morteza, Nakhjavani, Larry, Nargesi, Esteghamati (bb0535) 2013; 18 Redza-Dutordoir, Averill-Bates (bb0120) 2016; 1863 Ijuin, Hatano, Hosooka, Takenawa (bb0250) 2015; 1853 El-Horany, Abd-Ellatif, Watany, Hafez, Okda (bb0530) 2017; 69 Hoekstra, Bishop, Leicht (bb0620) 2020; 26 Lacetera (bb0090) 2016 Solinas, Becattini (bb0210) 2017; 6 Padmalayam (bb0715) 2014; 18 Reading, Hallberg, Myers (bb0325) 1989; 337 Dai, Patel-Chamberlin, Natarajan, Todorov, Ma, LaPage (bb0510) 2009; 150 Rajagopal, Kulkarni, Lewis, Chen, Maarouf, Kelly (bb0435) 2015; 114 Laybutt, Preston, Åkerfeldt, Kench, Busch, Biankin (bb0465) 2007; 50 Dong, Huang, Yun, Kim, Yue, Wu (bb0710) 2014; 155 Morimoto (bb0040) 2011; 76 Nowotny, Jung, Höhn, Weber, Grune (bb0100) 2015; 5 Milner, Campbell (bb0595) 1992; 36 Yang, Li, Yang, Xiao, Xiong, Chen (bb0230) 2020; 8 Halban, Polonsky, Bowden, Hawkins, Ling, Mather (bb0005) 2014; 99 Zhang, Liu, Zhang, Li, Fu, Zheng (bb0345) 2020; 18 Märker, Sell, Zillessen, Glöde, Kriebel, Ouwens (bb0360) 2012; 61 Chien, Aitken Jacqueline, Zhang, Buchanan Christina, Hickey, Brittain (bb0400) 2010; 432 Minchenko, Davydov, Budreiko, Moliavko, Kulieshova, Tiazhka (bb0160) 2015; 61 Umapathy, Krishnamoorthy, Muthukumaran, Rajaram, Padmalayam, Viswanathan (bb0575) 2012; 43 Simar, Jacques, Caillaud (bb0205) 2012; 17 Hoekstra, Bishop, Faulkner, Bailey, Leicht (bb0695) 2018; 125 Cabiscol, Bellí, Tamarit, Echave, Herrero, Ros (bb0330) 2002; 277 Lipson, Fonseca, Ishigaki, Nguyen, Foss, Bortell (bb0415) 2006; 4 Xiao, Liang, Liu, Zhang, Meng, Hu (bb0355) 2020; 64 Galicia-Garcia, Benito-Vicente, Jebari, Larrea-Sebal, Siddiqi, Uribe (bb0025) 2020; 21 Tytell, Davis, Giles, Snider, Xiao, Dozier (bb0725) 2018; 23 Jia, Tong, Min (bb0560) 2015; 37 Gao, Yechikov, Vazquez, Chen, Nie (bb0290) 2013; 8 Krause, Heck, Bittencourt, Scomazzon, Newsholme, Curi (bb0265) 2015; 2015 Brunt (10.1016/j.jdiacomp.2023.108564_bb0685) 2018; 596 Atkin (10.1016/j.jdiacomp.2023.108564_bb0145) 2021; 9 Tytell (10.1016/j.jdiacomp.2023.108564_bb0725) 2018; 23 Yang (10.1016/j.jdiacomp.2023.108564_bb0450) 2016; 53 Clark (10.1016/j.jdiacomp.2023.108564_bb0115) 2001; 50(suppl_1):S169-S Padmalayam (10.1016/j.jdiacomp.2023.108564_bb0715) 2014; 18 Henstridge (10.1016/j.jdiacomp.2023.108564_bb0220) 2014; 63 Reading (10.1016/j.jdiacomp.2023.108564_bb0325) 1989; 337 Faulkner (10.1016/j.jdiacomp.2023.108564_bb0680) 2017; 4 Ibrahim (10.1016/j.jdiacomp.2023.108564_bb0240) 2019; 226 Krause (10.1016/j.jdiacomp.2023.108564_bb0255) 2014; 126 El-Horany (10.1016/j.jdiacomp.2023.108564_bb0530) 2017; 69 Barbier-Torres (10.1016/j.jdiacomp.2023.108564_bb0285) 2020; 11 Nakhjavani (10.1016/j.jdiacomp.2023.108564_bb0125) 2012; 498 Zouari Bouassida (10.1016/j.jdiacomp.2023.108564_bb0570) 2004; 30 Redza-Dutordoir (10.1016/j.jdiacomp.2023.108564_bb0120) 2016; 1863 Farmer (10.1016/j.jdiacomp.2023.108564_bb0720) 2012; 2012 Hickey (10.1016/j.jdiacomp.2023.108564_bb0405) 2009; 8 Yan (10.1016/j.jdiacomp.2023.108564_bb0470) 2002; 99 Gomez-Pastor (10.1016/j.jdiacomp.2023.108564_bb0060) 2018; 19 Calderwood (10.1016/j.jdiacomp.2023.108564_bb0085) 2016 Gupta (10.1016/j.jdiacomp.2023.108564_bb0395) 2010; 8 Rajagopal (10.1016/j.jdiacomp.2023.108564_bb0435) 2015; 114 Drew (10.1016/j.jdiacomp.2023.108564_bb0225) 2014; 63 Anderson (10.1016/j.jdiacomp.2023.108564_bb0440) 2006; 10 Molina (10.1016/j.jdiacomp.2023.108564_bb0190) 2016; 18 Singh (10.1016/j.jdiacomp.2023.108564_bb0590) 2006; 11 Sakamoto (10.1016/j.jdiacomp.2023.108564_bb0500) 2002; 277 Long (10.1016/j.jdiacomp.2023.108564_bb0525) 2020; 20 Hoekstra (10.1016/j.jdiacomp.2023.108564_bb0620) 2020; 26 Brzozowska (10.1016/j.jdiacomp.2023.108564_bb0015) 2019 Kuan (10.1016/j.jdiacomp.2023.108564_bb0320) 2017; 292 Krause (10.1016/j.jdiacomp.2023.108564_bb0265) 2015; 2015 Umapathy (10.1016/j.jdiacomp.2023.108564_bb0575) 2012; 43 Muoio (10.1016/j.jdiacomp.2023.108564_bb0030) 2008; 9 Kavanagh (10.1016/j.jdiacomp.2023.108564_bb0185) 2009; 14 Dodd (10.1016/j.jdiacomp.2023.108564_bb0365) 2009; 23 Solinas (10.1016/j.jdiacomp.2023.108564_bb0210) 2017; 6 Venojärvi (10.1016/j.jdiacomp.2023.108564_bb0170) 2014; 2014 Han (10.1016/j.jdiacomp.2023.108564_bb0475) 2015; 64 Lei (10.1016/j.jdiacomp.2023.108564_bb0735) 2007; 282 Yuan (10.1016/j.jdiacomp.2023.108564_bb0135) 2011; 16 Silverstein (10.1016/j.jdiacomp.2023.108564_bb0670) 2015; 70 Edlitz (10.1016/j.jdiacomp.2023.108564_bb0515) 2022; 11 Hoekstra (10.1016/j.jdiacomp.2023.108564_bb0695) 2018; 125 Dong (10.1016/j.jdiacomp.2023.108564_bb0710) 2014; 155 Lytrivi (10.1016/j.jdiacomp.2023.108564_bb0485) 2021; 184 Simar (10.1016/j.jdiacomp.2023.108564_bb0205) 2012; 17 Halban (10.1016/j.jdiacomp.2023.108564_bb0005) 2014; 99 Ota (10.1016/j.jdiacomp.2023.108564_bb0445) 2012; 287 Kaneto (10.1016/j.jdiacomp.2023.108564_bb0095) 2010; 2010 Morteza (10.1016/j.jdiacomp.2023.108564_bb0535) 2013; 18 Ye (10.1016/j.jdiacomp.2023.108564_bb0455) 2009; 73 Christensen (10.1016/j.jdiacomp.2023.108564_bb0380) 2019; 19 Fakhruddin (10.1016/j.jdiacomp.2023.108564_bb0105) 2017; 2017 Hauffe (10.1016/j.jdiacomp.2023.108564_bb0340) 2021; 53 Ding (10.1016/j.jdiacomp.2023.108564_bb0540) 2022; 10 Mahmoud (10.1016/j.jdiacomp.2023.108564_bb0150) 2018; 23 Bouchecareilh (10.1016/j.jdiacomp.2023.108564_bb0045) 2011; 8 Kammoun (10.1016/j.jdiacomp.2023.108564_bb0245) 2009; 119 Abu-Farha (10.1016/j.jdiacomp.2023.108564_bb0180) 2015; 5 Chung (10.1016/j.jdiacomp.2023.108564_bb0165) 2008; 105 Alemi (10.1016/j.jdiacomp.2023.108564_bb0260) 2019; 24 Cavener (10.1016/j.jdiacomp.2023.108564_bb0420) 2010; 21 Jia (10.1016/j.jdiacomp.2023.108564_bb0560) 2015; 37 Ma (10.1016/j.jdiacomp.2023.108564_bb0130) 2021; 100 Febbraio (10.1016/j.jdiacomp.2023.108564_bb0655) 2000; 89 Tubbs (10.1016/j.jdiacomp.2023.108564_bb0235) 2014; 63 Jing (10.1016/j.jdiacomp.2023.108564_bb0295) 2018; 15 Ladiges (10.1016/j.jdiacomp.2023.108564_bb0480) 2005; 54 Kitano (10.1016/j.jdiacomp.2023.108564_bb0200) 2019; 316 Singh (10.1016/j.jdiacomp.2023.108564_bb0550) 2015; 29 López-Jaramillo (10.1016/j.jdiacomp.2023.108564_bb0020) 2014; 5 Galicia-Garcia (10.1016/j.jdiacomp.2023.108564_bb0025) 2020; 21 Kijima (10.1016/j.jdiacomp.2023.108564_bb0300) 2018; 8 Seibert (10.1016/j.jdiacomp.2023.108564_bb0585) 2022; 27 Tiwary (10.1016/j.jdiacomp.2023.108564_bb0430) 2021; 297 Gonzalez (10.1016/j.jdiacomp.2023.108564_bb0110) 2018; 1864 Zhao (10.1016/j.jdiacomp.2023.108564_bb0425) 2022; 71 Zubair (10.1016/j.jdiacomp.2023.108564_bb0555) 2018; 7 Hafen (10.1016/j.jdiacomp.2023.108564_bb0690) 2018; 125 Molanouri Shamsi (10.1016/j.jdiacomp.2023.108564_bb0635) 2016; 21 Gao (10.1016/j.jdiacomp.2023.108564_bb0290) 2013; 8 Cabiscol (10.1016/j.jdiacomp.2023.108564_bb0330) 2002; 277 Huang (10.1016/j.jdiacomp.2023.108564_bb0350) 2022; 23 Diane (10.1016/j.jdiacomp.2023.108564_bb0270) 2021; 67 Moniruzzaman (10.1016/j.jdiacomp.2023.108564_bb0580) 2020; 8 Xiao (10.1016/j.jdiacomp.2023.108564_bb0355) 2020; 64 Taherian (10.1016/j.jdiacomp.2023.108564_bb0305) 2008; 86 Reddy (10.1016/j.jdiacomp.2023.108564_bb0175) 2015; 67 Margulis (10.1016/j.jdiacomp.2023.108564_bb0615) 1991; 40 Laybutt (10.1016/j.jdiacomp.2023.108564_bb0465) 2007; 50 Dimitrovska (10.1016/j.jdiacomp.2023.108564_bb0700) 2018; 96 Sharma (10.1016/j.jdiacomp.2023.108564_bb0370) 2011; 106 Minchenko (10.1016/j.jdiacomp.2023.108564_bb0160) 2015; 61 Sun (10.1016/j.jdiacomp.2023.108564_bb0010) 2022; 183 Lee (10.1016/j.jdiacomp.2023.108564_bb0310) 2013; 430 Morimoto (10.1016/j.jdiacomp.2023.108564_bb0040) 2011; 76 Tzeng (10.1016/j.jdiacomp.2023.108564_bb0460) 2022; 71 Kravats (10.1016/j.jdiacomp.2023.108564_bb0075) 2018; 115 Guan (10.1016/j.jdiacomp.2023.108564_bb0495) 2016; 7 Njemini (10.1016/j.jdiacomp.2023.108564_bb0645) 2017; 93 Dorcely (10.1016/j.jdiacomp.2023.108564_bb0520) 2017; 10 Gober (10.1016/j.jdiacomp.2023.108564_bb0385) 2005; 10 Tsuzuki (10.1016/j.jdiacomp.2023.108564_bb0630) 2017; 22 Nakhjavani (10.1016/j.jdiacomp.2023.108564_bb0140) 2010; 15 Morino (10.1016/j.jdiacomp.2023.108564_bb0215) 2006; 55 Suppl 2 Gjøvaag (10.1016/j.jdiacomp.2023.108564_bb0660) 2006; 96 Zeng (10.1016/j.jdiacomp.2023.108564_bb0705) 2015; 172 Zhang (10.1016/j.jdiacomp.2023.108564_bb0345) 2020; 18 Lipson (10.1016/j.jdiacomp.2023.108564_bb0415) 2006; 4 Alderson (10.1016/j.jdiacomp.2023.108564_bb0070) 2020; 432 Yang (10.1016/j.jdiacomp.2023.108564_bb0505) 1997; 89 Kavanagh (10.1016/j.jdiacomp.2023.108564_bb0605) 2012; 67 Bruxel (10.1016/j.jdiacomp.2023.108564_bb0675) 2019; 156 Nakatani (10.1016/j.jdiacomp.2023.108564_bb0730) 2005; 280 Hatle (10.1016/j.jdiacomp.2023.108564_bb0280) 2013; 33 Elshahed (10.1016/j.jdiacomp.2023.108564_bb0565) 2020; 31 de Lemos Muller (10.1016/j.jdiacomp.2023.108564_bb0640) 2018; 111 Magalhães (10.1016/j.jdiacomp.2023.108564_bb0080) 2012; 22 Ritossa (10.1016/j.jdiacomp.2023.108564_bb0050) 1996; 1 Krause (10.1016/j.jdiacomp.2023.108564_bb0665) 2015; 18 ElGemei (10.1016/j.jdiacomp.2023.108564_bb0600) 2013; 22 Venojärvi (10.1016/j.jdiacomp.2023.108564_bb0650) 2008; 8 Dai (10.1016/j.jdiacomp.2023.108564_bb0510) 2009; 150 Yang (10.1016/j.jdiacomp.2023.108564_bb0230) 2020; 8 Lacetera (10.1016/j.jdiacomp.2023.108564_bb0090) 2016 Ijuin (10.1016/j.jdiacomp.2023.108564_bb0250) 2015; 1853 Rowles (10.1016/j.jdiacomp.2023.108564_bb0035) 2020; 21 Butler (10.1016/j.jdiacomp.2023.108564_bb0375) 2003; 52 Verma (10.1016/j.jdiacomp.2023.108564_bb0065) 2021; 10 Chien (10.1016/j.jdiacomp.2023.108564_bb0400) 2010; 432 Cherian (10.1016/j.jdiacomp.2023.108564_bb0155) 2018; 9 Kleinridders (10.1016/j.jdiacomp.2023.108564_bb0335) 2013; 123 Märker (10.1016/j.jdiacomp.2023.108564_bb0360) 2012; 61 Stankiewicz (10.1016/j.jdiacomp.2023.108564_bb0390) 2005; 280 Milner (10.1016/j.jdiacomp.2023.108564_bb0595) 1992; 36 Abubaker (10.1016/j.jdiacomp.2023.108564_bb0055) 2013; 8 Zheng (10.1016/j.jdiacomp.2023.108564_bb0315) 2019; 9 Kim (10.1016/j.jdiacomp.2023.108564_bb0490) 2006; 580 Archer (10.1016/j.jdiacomp.2023.108564_bb0610) 2018; 373 Wang (10.1016/j.jdiacomp.2023.108564_bb0545) 2020; 20 Nowotny (10.1016/j.jdiacomp.2023.108564_bb0100) 2015; 5 Read (10.1016/j.jdiacomp.2023.108564_bb0410) 2021; 10 Sun (10.1016/j.jdiacomp.2023.108564_bb0275) 2020; 30 Ogura (10.1016/j.jdiacomp.2023.108564_bb0625) 2008; 294 |
| References_xml | – volume: 2010 year: 2010 ident: bb0095 article-title: Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis publication-title: Mediators Inflamm – volume: 99 start-page: 1983 year: 2014 end-page: 1992 ident: bb0005 article-title: β-Cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment publication-title: J Clin Endocrinol Metabol – volume: 53 year: 2021 ident: bb0340 article-title: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue publication-title: Mol Metab – volume: 126 start-page: 739 year: 2014 end-page: 752 ident: bb0255 article-title: Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro publication-title: Clin Sci (Lond) – volume: 297 year: 2021 ident: bb0430 article-title: GRP75 mediates endoplasmic reticulum-mitochondria coupling during palmitate-induced pancreatic β-cell apoptosis publication-title: J Biol Chem – volume: 4 start-page: 292 year: 2017 end-page: 304 ident: bb0680 article-title: The effect of passive heating on heat shock protein 70 and interleukin-6: a possible treatment tool for metabolic diseases? publication-title: Temperature (Austin) – volume: 277 start-page: 44531 year: 2002 end-page: 44538 ident: bb0330 article-title: Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae * publication-title: J Biol Chem – volume: 119 start-page: 1201 year: 2009 end-page: 1215 ident: bb0245 article-title: GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice publication-title: J Clin Invest – volume: 99 start-page: 15920 year: 2002 end-page: 15925 ident: bb0470 article-title: Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK publication-title: Proc Natl Acad Sci U S A – volume: 63 start-page: 3279 year: 2014 end-page: 3294 ident: bb0235 article-title: Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance publication-title: Diabetes. – volume: 2017 start-page: 8379327 year: 2017 ident: bb0105 article-title: Diabetes-induced reactive oxygen species: mechanism of their generation and role in renal injury publication-title: J Diabetes Res – volume: 21 start-page: 714 year: 2010 end-page: 721 ident: bb0420 article-title: PERK in beta cell biology and insulin biogenesis publication-title: Trends Endocrinol Metab – volume: 43 start-page: 250 year: 2012 end-page: 255 ident: bb0575 article-title: Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein 70 genes with type 2 diabetes publication-title: Lab Med – volume: 54 start-page: 1074 year: 2005 end-page: 1081 ident: bb0480 article-title: Pancreatic β-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK publication-title: Diabetes. – volume: 5 start-page: 747 year: 2014 end-page: 755 ident: bb0020 article-title: Is the present cut-point to define type 2 diabetes appropriate in Latin-Americans? publication-title: World J Diabetes – volume: 93 start-page: 46 year: 2017 end-page: 53 ident: bb0645 article-title: Sex difference in the heat shock response to high external load resistance training in older humans publication-title: Exp Gerontol – volume: 64 start-page: 67 year: 2020 end-page: 75 ident: bb0355 article-title: Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis publication-title: J Mol Endocrinol – volume: 16 start-page: 689 year: 2011 end-page: 693 ident: bb0135 article-title: Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects publication-title: Cell Stress Chaperones – volume: 23 year: 2022 ident: bb0350 article-title: Heat shock protein 60 restricts release of mitochondrial dsRNA to suppress hepatic inflammation and ameliorate non-alcoholic fatty liver disease in mice publication-title: Int J Mol Sci – volume: 61 start-page: 10 year: 2015 end-page: 18 ident: bb0160 article-title: The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance publication-title: Fiziol Zh (1994) – volume: 33 start-page: 2302 year: 2013 end-page: 2314 ident: bb0280 article-title: MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations publication-title: Mol Cell Biol – volume: 8 year: 2020 ident: bb0580 article-title: Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population publication-title: Mol Genet Genomic Med – volume: 316 start-page: E305 year: 2019 end-page: e18 ident: bb0200 article-title: Impact of hepatic HSP72 on insulin signaling publication-title: Am J Physiol Endocrinol Metab – volume: 9 start-page: 193 year: 2008 end-page: 205 ident: bb0030 article-title: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes publication-title: Nat Rev Mol Cell Biol – volume: 282 start-page: 9364 year: 2007 end-page: 9371 ident: bb0735 article-title: Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes publication-title: J Biol Chem – volume: 76 start-page: 91 year: 2011 end-page: 99 ident: bb0040 article-title: The heat shock response: systems biology of proteotoxic stress in aging and disease publication-title: Cold Spring Harb Symp Quant Biol – volume: 277 start-page: 45770 year: 2002 end-page: 45775 ident: bb0500 article-title: Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification publication-title: J Biol Chem – volume: 337 start-page: 655 year: 1989 end-page: 659 ident: bb0325 article-title: Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor publication-title: Nature. – volume: 432 start-page: 3033 year: 2020 end-page: 3049 ident: bb0070 article-title: Conditional disorder in small heat-shock proteins publication-title: J Mol Biol – volume: 11 year: 2022 ident: bb0515 article-title: Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards publication-title: eLife. – volume: 6 start-page: 174 year: 2017 end-page: 184 ident: bb0210 article-title: JNK at the crossroad of obesity, insulin resistance, and cell stress response publication-title: Mol Metab – volume: 61 start-page: 615 year: 2012 end-page: 625 ident: bb0360 article-title: Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance publication-title: Diabetes. – volume: 432 start-page: 113 year: 2010 end-page: 121 ident: bb0400 article-title: The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in type 2 diabetes publication-title: Biochem J – volume: 40 start-page: 1418 year: 1991 end-page: 1422 ident: bb0615 article-title: Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function publication-title: Diabetes. – volume: 1 start-page: 97 year: 1996 end-page: 98 ident: bb0050 article-title: Discovery of the heat shock response publication-title: Cell Stress Chaperones – volume: 183 year: 2022 ident: bb0010 article-title: IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 publication-title: Diabetes Res Clin Pract – volume: 21 start-page: 783 year: 2016 end-page: 791 ident: bb0635 article-title: Effect of resistance exercise training on expression of Hsp70 and inflammatory cytokines in skeletal muscle and adipose tissue of STZ-induced diabetic rats publication-title: Cell Stress Chaperones – volume: 67 start-page: 1014 year: 2012 end-page: 1021 ident: bb0605 article-title: Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance publication-title: J Gerontol A – volume: 5 start-page: 14448 year: 2015 ident: bb0180 article-title: DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression publication-title: Sci Rep – volume: 10 year: 2021 ident: bb0410 article-title: The unfolded protein response: an overview publication-title: Biology (Basel) – volume: 36 start-page: 357 year: 1992 end-page: 362 ident: bb0595 article-title: Polymorphic analysis of the three MHC-linked HSP70 genes publication-title: Immunogenetics. – volume: 89 start-page: 1067 year: 1997 end-page: 1076 ident: bb0505 article-title: Daxx, a novel Fas-binding protein that activates JNK and apoptosis publication-title: Cell. – volume: 50 start-page: 752 year: 2007 end-page: 763 ident: bb0465 article-title: Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes publication-title: Diabetologia. – volume: 10 year: 2022 ident: bb0540 article-title: Extracellular Hsp90α, which participates in vascular inflammation, is a novel serum predictor of atherosclerosis in type 2 diabetes publication-title: BMJ Open Diabetes Res Care – volume: 280 start-page: 847 year: 2005 end-page: 851 ident: bb0730 article-title: Involvement of endoplasmic reticulum stress in insulin resistance and diabetes publication-title: J Biol Chem – volume: 67 start-page: 291 year: 2015 end-page: 299 ident: bb0175 article-title: Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle publication-title: IUBMB Life – volume: 21 year: 2020 ident: bb0035 article-title: Are heat shock proteins an important link between type 2 diabetes and Alzheimer disease? publication-title: Int J Mol Sci – volume: 105 start-page: 1739 year: 2008 end-page: 1744 ident: bb0165 article-title: HSP72 protects against obesity-induced insulin resistance publication-title: Proc Natl Acad Sci U S A – volume: 69 start-page: 623 year: 2017 end-page: 630 ident: bb0530 article-title: NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients publication-title: IUBMB Life – volume: 125 start-page: 1447 year: 2018 end-page: 1455 ident: bb0690 article-title: Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle publication-title: J Appl Physiol (1985) – start-page: 20 year: 2019 ident: bb0015 article-title: Genetics, adaptation to environmental changes and archaic admixture in the pathogenesis of diabetes mellitus in Indigenous Australians publication-title: Rev Endocr Metab Disord – volume: 8 start-page: 189 year: 2011 end-page: 195 ident: bb0045 article-title: Proteostasis: a new therapeutic paradigm for pulmonary disease publication-title: Proc Am Thorac Soc – volume: 22 start-page: 8 year: 2012 end-page: 13 ident: bb0080 article-title: Heat Shock Proteins (HSP): dermatological implications and perspectives publication-title: Eur J Dermatol – volume: 11 start-page: 3360 year: 2020 ident: bb0285 article-title: Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation publication-title: Nat Commun – volume: 125 start-page: 2008 year: 2018 end-page: 2018 ident: bb0695 article-title: Acute and chronic effects of hot water immersion on inflammation and metabolism in sedentary, overweight adults publication-title: J Appl Physiol (1985) – volume: 71 year: 2022 ident: bb0460 article-title: 245-LB: an ankyrin-B–mediated protein chaperone mechanism modulates pancreatic ß-cell susceptibility to proteotoxicity-induced ER stress and apoptosis publication-title: Diabetes. – volume: 86 start-page: 37 year: 2008 end-page: 45 ident: bb0305 article-title: A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates publication-title: Biochem Cell Biol – volume: 1864 start-page: 3805 year: 2018 end-page: 3823 ident: bb0110 article-title: Type 2 diabetes – an autoinflammatory disease driven by metabolic stress publication-title: Biochim Biophys Acta Mol Basis Dis – volume: 2015 year: 2015 ident: bb0265 article-title: The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management publication-title: Mediators Inflamm – volume: 11 start-page: 208 year: 2006 end-page: 215 ident: bb0590 article-title: Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes publication-title: Cell Stress Chaperones – volume: 22 start-page: 1183 year: 2013 end-page: 1188 ident: bb0600 article-title: The association between heat shock protein P2/P2 genotype with Egyptian hepatocellular carcinoma patients publication-title: Comp Clin Pathol – volume: 29 start-page: 578 year: 2015 end-page: 588 ident: bb0550 article-title: Decreased expression of heat shock proteins may lead to compromised wound healing in type 2 diabetes mellitus patients publication-title: J Diabetes Complications – volume: 27 start-page: 523 year: 2022 end-page: 534 ident: bb0585 article-title: Increased eHSP70-to-iHSP70 ratio in prediabetic and diabetic postmenopausal women: a biomarker of cardiometabolic risk publication-title: Cell Stress Chaperones – volume: 30 start-page: 175 year: 2004 end-page: 180 ident: bb0570 article-title: Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity publication-title: Diabetes Metab – volume: 150 start-page: 3031 year: 2009 end-page: 3039 ident: bb0510 article-title: Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes publication-title: Endocrinology. – volume: 226 start-page: 156 year: 2019 end-page: 163 ident: bb0240 article-title: GRP78: a cell’s response to stress publication-title: Life Sci – start-page: 107 year: 2016 end-page: 131 ident: bb0090 article-title: Chapter 5 - metabolic stress, heat shock proteins, and innate immune response publication-title: The Innate Immune Response to Noninfectious Stressors – volume: 498 start-page: 107 year: 2012 end-page: 111 ident: bb0125 article-title: The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes publication-title: Gene. – volume: 7 year: 2018 ident: bb0555 article-title: Heat shock protein 70 gene single nucleotide polymorphism and diabetic foot ulcer. Is there any relationship? publication-title: J Clin Med – volume: 106 start-page: 1713 year: 2011 end-page: 1723 ident: bb0370 article-title: Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes publication-title: Br J Nutr – volume: 53 start-page: 621 year: 2016 end-page: 628 ident: bb0450 article-title: Potential role of Hsp90 in rat islet function under the condition of high glucose publication-title: Acta Diabetol – volume: 10 start-page: 72 year: 2021 ident: bb0065 article-title: Recent advances in understanding the role of proteostasis publication-title: Fac Rev – volume: 430 start-page: 1109 year: 2013 end-page: 1113 ident: bb0310 article-title: Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice publication-title: Biochem Biophys Res Commun – volume: 18 start-page: 29 year: 2014 end-page: 39 ident: bb0715 article-title: The heat shock response: its role in pathogenesis of type 2 diabetes and its complications, and implications for therapeutic intervention publication-title: Discov Med – volume: 15 start-page: 959 year: 2010 end-page: 964 ident: bb0140 article-title: Increased serum HSP70 levels are associated with the duration of diabetes publication-title: Cell Stress Chaperones – volume: 23 start-page: 3415 year: 2009 end-page: 3423 ident: bb0365 article-title: Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy publication-title: FASEB J – volume: 1863 start-page: 2977 year: 2016 end-page: 2992 ident: bb0120 article-title: Activation of apoptosis signalling pathways by reactive oxygen species publication-title: Biochim Biophys Acta Mol Cell Res – volume: 18 start-page: 60 year: 2020 ident: bb0345 article-title: Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor publication-title: Cell Commun Signal – volume: 2012 year: 2012 ident: bb0720 article-title: KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability publication-title: Exp Diabetes Res – volume: 287 start-page: 6266 year: 2012 end-page: 6274 ident: bb0445 article-title: Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells publication-title: J Biol Chem – volume: 31 start-page: 787 year: 2020 end-page: 795 ident: bb0565 article-title: Heat shock protein 70 gene polymorphism in Egyptian patients with type 2 diabetes mellitus, with and without nephropathy publication-title: Saudi J Kidney Dis Transpl – volume: 50(suppl_1):S169-S year: 2001 ident: bb0115 article-title: Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function? publication-title: Diabetes. – volume: 8 year: 2010 ident: bb0395 article-title: HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction publication-title: PLoS Biol – volume: 155 start-page: 818 year: 2014 end-page: 828 ident: bb0710 article-title: Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation publication-title: Endocrinology. – volume: 71 start-page: 233 year: 2022 end-page: 248 ident: bb0425 article-title: GRP75 regulates mitochondrial-supercomplex turnover to modulate insulin sensitivity publication-title: Diabetes. – volume: 73 start-page: 1787 year: 2009 end-page: 1792 ident: bb0455 article-title: HSP40 ameliorates impairment of insulin secretion by inhibiting huntingtin aggregation in a HD pancreatic beta cell model publication-title: Biosci Biotechnol Biochem – volume: 123 start-page: 4667 year: 2013 end-page: 4680 ident: bb0335 article-title: Leptin regulation of Hsp60 impacts hypothalamic insulin signaling publication-title: J Clin Invest – volume: 9 start-page: 5769 year: 2019 end-page: 5783 ident: bb0315 article-title: Inhibition of HSP90β improves lipid disorders by promoting mature SREBPs degradation via the ubiquitin-proteasome system publication-title: Theranostics. – volume: 580 start-page: 2311 year: 2006 end-page: 2316 ident: bb0490 article-title: Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic β-cell death under hyperglycemic conditions publication-title: FEBS Lett – volume: 8 start-page: 595 year: 2020 ident: bb0230 article-title: Mitochondria-associated ER membranes - the origin site of autophagy publication-title: Front Cell Dev Biol – volume: 4 start-page: 245 year: 2006 end-page: 254 ident: bb0415 article-title: Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1 publication-title: Cell Metab – volume: 114 start-page: 83 year: 2015 end-page: 92 ident: bb0435 article-title: Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function publication-title: J Proteomics – volume: 8 start-page: 178 year: 2009 end-page: 186 ident: bb0405 article-title: Proteins associated with immunopurified granules from a model pancreatic islet beta-cell system: proteomic snapshot of an endocrine secretory granule publication-title: J Proteome Res – volume: 89 start-page: 1055 year: 2000 end-page: 1060 ident: bb0655 article-title: HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise publication-title: J Appl Physiol (1985) – volume: 63 start-page: 1881 year: 2014 end-page: 1894 ident: bb0220 article-title: Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance publication-title: Diabetes. – volume: 21 year: 2020 ident: bb0025 article-title: Pathophysiology of type 2 diabetes mellitus publication-title: Int J Mol Sci – volume: 8 start-page: 3 year: 2008 ident: bb0650 article-title: Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance publication-title: BMC Endocr Disord – volume: 156 start-page: 33 year: 2019 end-page: 46 ident: bb0675 article-title: Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice publication-title: Biochimie. – volume: 63 start-page: 1488 year: 2014 end-page: 1505 ident: bb0225 article-title: HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle publication-title: Diabetes. – volume: 8 year: 2013 ident: bb0055 article-title: DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise publication-title: PloS One – volume: 18 start-page: 815 year: 2013 end-page: 819 ident: bb0535 article-title: Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study publication-title: Cell Stress Chaperones – volume: 70 start-page: 800 year: 2015 end-page: 808 ident: bb0670 article-title: Inducing muscle heat shock protein 70 improves insulin sensitivity and muscular performance in aged mice publication-title: J Gerontol A Biol Sci Med Sci – volume: 8 year: 2013 ident: bb0290 article-title: Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels publication-title: PloS One – volume: 30 year: 2020 ident: bb0275 article-title: Hepatic DNAJB9 drives anabolic biasing to reduce steatosis and obesity publication-title: Cell Rep – volume: 18 start-page: 1 year: 2016 ident: bb0190 article-title: Emerging role of nitric oxide and heat shock proteins in insulin resistance publication-title: Curr Hypertens Rep – volume: 15 start-page: 11 year: 2018 ident: bb0295 article-title: Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance publication-title: Nutr Metab (Lond) – volume: 292 start-page: 3016 year: 2017 end-page: 3028 ident: bb0320 article-title: Heat shock protein 90 modulates lipid homeostasis by regulating the stability and function of sterol regulatory element-binding protein (SREBP) and SREBP cleavage-activating protein publication-title: J Biol Chem – volume: 67 year: 2021 ident: bb0270 article-title: Role of the DNAJ/HSP40 family in the pathogenesis of insulin resistance and type 2 diabetes publication-title: Ageing Res Rev – volume: 111 start-page: 180 year: 2018 end-page: 187 ident: bb0640 article-title: Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training publication-title: Exp Gerontol – volume: 26 start-page: 42 year: 2020 end-page: 55 ident: bb0620 article-title: Elevating body termperature to reduce low-grade inflammation: a welcome strategy for those unable to exercise? publication-title: Exerc Immunol Rev – volume: 294 start-page: R1600 year: 2008 end-page: R1607 ident: bb0625 article-title: Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasma publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 37 start-page: 683 year: 2015 end-page: 687 ident: bb0560 article-title: Significance of functional GRP78 polymorphisms in predicting the onset of type 2 diabetic peripheral neuropathy in Chinese population publication-title: Neurol Res – volume: 22 start-page: 263 year: 2017 end-page: 269 ident: bb0630 article-title: Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes publication-title: Cell Stress Chaperones – volume: 596 start-page: 4831 year: 2018 end-page: 4845 ident: bb0685 article-title: Passive heat therapy protects against endothelial cell hypoxia-reoxygenation via effects of elevations in temperature and circulating factors publication-title: J Physiol – volume: 10 start-page: 126 year: 2006 end-page: 131 ident: bb0440 article-title: Discovery of the ‘porosome’ the universal secretory machinery in cells publication-title: J Cell Mol Med – volume: 24 start-page: 69 year: 2019 end-page: 75 ident: bb0260 article-title: Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein publication-title: Cell Stress Chaperones – volume: 2014 year: 2014 ident: bb0170 article-title: Decreased thioredoxin-1 and increased HSP90 expression in skeletal muscle in subjects with type 2 diabetes or impaired glucose tolerance publication-title: Biomed Res Int – volume: 23 start-page: 955 year: 2018 end-page: 965 ident: bb0150 article-title: Correlation between heat shock proteins, adiponectin, and T lymphocyte cytokine expression in type 2 diabetics publication-title: Cell Stress Chaperones – volume: 10 start-page: 345 year: 2017 end-page: 361 ident: bb0520 article-title: Novel biomarkers for prediabetes, diabetes, and associated complications publication-title: Diabetes Metab Syndr Obes – volume: 14 start-page: 291 year: 2009 end-page: 299 ident: bb0185 article-title: Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys publication-title: Cell Stress Chaperones – volume: 19 start-page: 4 year: 2018 end-page: 19 ident: bb0060 article-title: Regulation of heat shock transcription factors and their roles in physiology and disease publication-title: Nat Rev Mol Cell Biol – volume: 7 start-page: 23072 year: 2016 end-page: 23087 ident: bb0495 article-title: The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction publication-title: Oncotarget. – volume: 96 start-page: 355 year: 2006 end-page: 362 ident: bb0660 article-title: Effect of concentric or eccentric weight training on the expression of heat shock proteins in m. biceps brachii of very well trained males publication-title: Eur J Appl Physiol – volume: 52 start-page: 102 year: 2003 end-page: 110 ident: bb0375 article-title: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes publication-title: Diabetes. – volume: 96 start-page: 158 year: 2018 end-page: 164 ident: bb0700 article-title: Physiological and pharmacological inductors of HSP70 enhance the antioxidative defense mechanisms of the liver and pancreas in diabetic rats publication-title: Can J Physiol Pharmacol – volume: 8 start-page: 6976 year: 2018 ident: bb0300 article-title: HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation publication-title: Sci Rep – volume: 18 start-page: 374 year: 2015 end-page: 380 ident: bb0665 article-title: Heat shock proteins and heat therapy for type 2 diabetes: pros and cons publication-title: Curr Opin Clin Nutr Metab Care – volume: 19 start-page: 81 year: 2019 ident: bb0380 article-title: The beta cell in type 2 diabetes publication-title: Curr Diab Rep – volume: 172 start-page: 4303 year: 2015 end-page: 4318 ident: bb0705 article-title: Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target publication-title: Br J Pharmacol – volume: 9 start-page: 423 year: 2018 ident: bb0155 article-title: Increased circulation and adipose tissue levels of DNAJC27/RBJ in obesity and type 2-diabetes publication-title: Front Endocrinol (Lausanne) – volume: 280 start-page: 38729 year: 2005 end-page: 38739 ident: bb0390 article-title: Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation publication-title: J Biol Chem – volume: 5 start-page: 194 year: 2015 end-page: 222 ident: bb0100 article-title: Advanced glycation end products and oxidative stress in type 2 diabetes mellitus publication-title: Biomolecules. – volume: 10 start-page: 2788 year: 2005 end-page: 2803 ident: bb0385 article-title: Herpes simplex virus type 2 encodes a heat shock protein homologue with apoptosis regulatory functions publication-title: Front Biosci – volume: 1853 start-page: 3192 year: 2015 end-page: 3201 ident: bb0250 article-title: Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78 publication-title: Biochim Biophys Acta – volume: 9 year: 2021 ident: bb0145 article-title: Plasma heat shock protein response to euglycemia in type 2 diabetes publication-title: BMJ Open Diabetes Res Care – volume: 115 start-page: E2210 year: 2018 end-page: e9 ident: bb0075 article-title: Functional and physical interaction between yeast Hsp90 and Hsp70 publication-title: Proc Natl Acad Sci U S A – volume: 20 start-page: 198 year: 2020 ident: bb0545 article-title: Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study publication-title: BMC Cardiovasc Disord – volume: 373 year: 2018 ident: bb0610 article-title: Exercise, heat shock proteins and insulin resistance publication-title: Philos Trans R Soc Lond B Biol Sci – volume: 100 year: 2021 ident: bb0130 article-title: Levels of circulating GRP78 and CHOP in endoplasmic reticulum stress pathways in Chinese type 2 diabetic kidney disease patients publication-title: Medicine (Baltimore) – volume: 55 Suppl 2 start-page: S9 year: 2006 end-page: s15 ident: bb0215 article-title: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction publication-title: Diabetes. – volume: 184 start-page: 455 year: 2021 end-page: 468 ident: bb0485 article-title: DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes publication-title: Eur J Endocrinol – volume: 64 start-page: 2892 year: 2015 end-page: 2904 ident: bb0475 article-title: Antioxidants complement the requirement for protein chaperone function to maintain β-cell function and glucose homeostasis publication-title: Diabetes. – volume: 23 start-page: 189 year: 2018 end-page: 194 ident: bb0725 article-title: Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice publication-title: Cell Stress Chaperones – volume: 17 start-page: 615 year: 2012 end-page: 621 ident: bb0205 article-title: Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects publication-title: Cell Stress Chaperones – volume: 20 start-page: 174 year: 2020 ident: bb0525 article-title: Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis publication-title: BMC Endocr Disord – start-page: 7 year: 2016 ident: bb0085 article-title: Extracellular HSPs: the complicated roles of extracellular HSPs in immunity publication-title: Front Immunol – volume: 67 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0270 article-title: Role of the DNAJ/HSP40 family in the pathogenesis of insulin resistance and type 2 diabetes publication-title: Ageing Res Rev doi: 10.1016/j.arr.2021.101313 – volume: 18 start-page: 374 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0665 article-title: Heat shock proteins and heat therapy for type 2 diabetes: pros and cons publication-title: Curr Opin Clin Nutr Metab Care doi: 10.1097/MCO.0000000000000183 – volume: 70 start-page: 800 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0670 article-title: Inducing muscle heat shock protein 70 improves insulin sensitivity and muscular performance in aged mice publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glu119 – volume: 22 start-page: 263 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0630 article-title: Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes publication-title: Cell Stress Chaperones doi: 10.1007/s12192-017-0767-z – volume: 31 start-page: 787 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0565 article-title: Heat shock protein 70 gene polymorphism in Egyptian patients with type 2 diabetes mellitus, with and without nephropathy publication-title: Saudi J Kidney Dis Transpl doi: 10.4103/1319-2442.292312 – volume: 18 start-page: 60 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0345 article-title: Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor publication-title: Cell Commun Signal doi: 10.1186/s12964-020-00546-5 – volume: 71 start-page: 233 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0425 article-title: GRP75 regulates mitochondrial-supercomplex turnover to modulate insulin sensitivity publication-title: Diabetes. doi: 10.2337/db21-0173 – volume: 2012 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0720 article-title: KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability publication-title: Exp Diabetes Res doi: 10.1155/2012/671673 – volume: 9 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0145 article-title: Plasma heat shock protein response to euglycemia in type 2 diabetes publication-title: BMJ Open Diabetes Res Care doi: 10.1136/bmjdrc-2020-002057 – volume: 498 start-page: 107 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0125 article-title: The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes publication-title: Gene. doi: 10.1016/j.gene.2012.01.085 – volume: 22 start-page: 8 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0080 article-title: Heat Shock Proteins (HSP): dermatological implications and perspectives publication-title: Eur J Dermatol doi: 10.1684/ejd.2011.1530 – volume: 150 start-page: 3031 year: 2009 ident: 10.1016/j.jdiacomp.2023.108564_bb0510 article-title: Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes publication-title: Endocrinology. doi: 10.1210/en.2008-0732 – volume: 71 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0460 article-title: 245-LB: an ankyrin-B–mediated protein chaperone mechanism modulates pancreatic ß-cell susceptibility to proteotoxicity-induced ER stress and apoptosis publication-title: Diabetes. doi: 10.2337/db22-245-LB – volume: 8 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0580 article-title: Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population publication-title: Mol Genet Genomic Med doi: 10.1002/mgg3.1073 – volume: 17 start-page: 615 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0205 article-title: Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects publication-title: Cell Stress Chaperones doi: 10.1007/s12192-012-0336-4 – volume: 23 start-page: 955 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0150 article-title: Correlation between heat shock proteins, adiponectin, and T lymphocyte cytokine expression in type 2 diabetics publication-title: Cell Stress Chaperones doi: 10.1007/s12192-018-0903-4 – volume: 19 start-page: 81 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0380 article-title: The beta cell in type 2 diabetes publication-title: Curr Diab Rep doi: 10.1007/s11892-019-1196-4 – volume: 93 start-page: 46 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0645 article-title: Sex difference in the heat shock response to high external load resistance training in older humans publication-title: Exp Gerontol doi: 10.1016/j.exger.2017.04.005 – volume: 1863 start-page: 2977 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0120 article-title: Activation of apoptosis signalling pathways by reactive oxygen species publication-title: Biochim Biophys Acta Mol Cell Res doi: 10.1016/j.bbamcr.2016.09.012 – volume: 183 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0010 article-title: IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2021.109119 – volume: 8 start-page: 3 year: 2008 ident: 10.1016/j.jdiacomp.2023.108564_bb0650 article-title: Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance publication-title: BMC Endocr Disord doi: 10.1186/1472-6823-8-3 – volume: 63 start-page: 1488 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0225 article-title: HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle publication-title: Diabetes. doi: 10.2337/db13-0665 – volume: 18 start-page: 29 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0715 article-title: The heat shock response: its role in pathogenesis of type 2 diabetes and its complications, and implications for therapeutic intervention publication-title: Discov Med – volume: 23 start-page: 3415 year: 2009 ident: 10.1016/j.jdiacomp.2023.108564_bb0365 article-title: Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy publication-title: FASEB J doi: 10.1096/fj.08-124602 – volume: 9 start-page: 5769 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0315 article-title: Inhibition of HSP90β improves lipid disorders by promoting mature SREBPs degradation via the ubiquitin-proteasome system publication-title: Theranostics. doi: 10.7150/thno.36505 – volume: 8 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0290 article-title: Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels publication-title: PloS One – volume: 4 start-page: 245 year: 2006 ident: 10.1016/j.jdiacomp.2023.108564_bb0415 article-title: Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1 publication-title: Cell Metab doi: 10.1016/j.cmet.2006.07.007 – volume: 54 start-page: 1074 year: 2005 ident: 10.1016/j.jdiacomp.2023.108564_bb0480 article-title: Pancreatic β-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK publication-title: Diabetes. doi: 10.2337/diabetes.54.4.1074 – volume: 53 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0340 article-title: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue publication-title: Mol Metab doi: 10.1016/j.molmet.2021.101276 – volume: 8 year: 2010 ident: 10.1016/j.jdiacomp.2023.108564_bb0395 article-title: HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction publication-title: PLoS Biol doi: 10.1371/journal.pbio.1000410 – volume: 155 start-page: 818 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0710 article-title: Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation publication-title: Endocrinology. doi: 10.1210/en.2013-1667 – volume: 2014 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0170 article-title: Decreased thioredoxin-1 and increased HSP90 expression in skeletal muscle in subjects with type 2 diabetes or impaired glucose tolerance publication-title: Biomed Res Int doi: 10.1155/2014/386351 – volume: 33 start-page: 2302 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0280 article-title: MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations publication-title: Mol Cell Biol doi: 10.1128/MCB.00189-13 – volume: 430 start-page: 1109 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0310 article-title: Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2012.12.029 – volume: 337 start-page: 655 year: 1989 ident: 10.1016/j.jdiacomp.2023.108564_bb0325 article-title: Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor publication-title: Nature. doi: 10.1038/337655a0 – volume: 10 start-page: 2788 year: 2005 ident: 10.1016/j.jdiacomp.2023.108564_bb0385 article-title: Herpes simplex virus type 2 encodes a heat shock protein homologue with apoptosis regulatory functions publication-title: Front Biosci doi: 10.2741/1736 – volume: 280 start-page: 38729 year: 2005 ident: 10.1016/j.jdiacomp.2023.108564_bb0390 article-title: Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation publication-title: J Biol Chem doi: 10.1074/jbc.M509497200 – volume: 18 start-page: 815 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0535 article-title: Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study publication-title: Cell Stress Chaperones doi: 10.1007/s12192-013-0435-x – volume: 8 start-page: 6976 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0300 article-title: HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation publication-title: Sci Rep doi: 10.1038/s41598-018-25404-w – volume: 30 start-page: 175 year: 2004 ident: 10.1016/j.jdiacomp.2023.108564_bb0570 article-title: Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity publication-title: Diabetes Metab doi: 10.1016/S1262-3636(07)70104-0 – volume: 114 start-page: 83 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0435 article-title: Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function publication-title: J Proteomics doi: 10.1016/j.jprot.2014.11.010 – volume: 115 start-page: E2210 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0075 article-title: Functional and physical interaction between yeast Hsp90 and Hsp70 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1719969115 – volume: 277 start-page: 44531 year: 2002 ident: 10.1016/j.jdiacomp.2023.108564_bb0330 article-title: Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae * publication-title: J Biol Chem doi: 10.1074/jbc.M206525200 – volume: 96 start-page: 158 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0700 article-title: Physiological and pharmacological inductors of HSP70 enhance the antioxidative defense mechanisms of the liver and pancreas in diabetic rats publication-title: Can J Physiol Pharmacol doi: 10.1139/cjpp-2017-0394 – volume: 106 start-page: 1713 year: 2011 ident: 10.1016/j.jdiacomp.2023.108564_bb0370 article-title: Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes publication-title: Br J Nutr doi: 10.1017/S000711451100225X – volume: 282 start-page: 9364 year: 2007 ident: 10.1016/j.jdiacomp.2023.108564_bb0735 article-title: Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes publication-title: J Biol Chem doi: 10.1074/jbc.M608985200 – volume: 432 start-page: 113 year: 2010 ident: 10.1016/j.jdiacomp.2023.108564_bb0400 article-title: The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in type 2 diabetes publication-title: Biochem J doi: 10.1042/BJ20100434 – volume: 23 start-page: 189 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0725 article-title: Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice publication-title: Cell Stress Chaperones doi: 10.1007/s12192-017-0835-4 – volume: 30 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0275 article-title: Hepatic DNAJB9 drives anabolic biasing to reduce steatosis and obesity publication-title: Cell Rep doi: 10.1016/j.celrep.2020.01.043 – volume: 5 start-page: 14448 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0180 article-title: DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression publication-title: Sci Rep doi: 10.1038/srep14448 – volume: 40 start-page: 1418 year: 1991 ident: 10.1016/j.jdiacomp.2023.108564_bb0615 article-title: Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function publication-title: Diabetes. doi: 10.2337/diab.40.11.1418 – volume: 99 start-page: 1983 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0005 article-title: β-Cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment publication-title: J Clin Endocrinol Metabol doi: 10.1210/jc.2014-1425 – volume: 8 start-page: 189 year: 2011 ident: 10.1016/j.jdiacomp.2023.108564_bb0045 article-title: Proteostasis: a new therapeutic paradigm for pulmonary disease publication-title: Proc Am Thorac Soc doi: 10.1513/pats.201008-055MS – volume: 16 start-page: 689 year: 2011 ident: 10.1016/j.jdiacomp.2023.108564_bb0135 article-title: Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects publication-title: Cell Stress Chaperones doi: 10.1007/s12192-011-0281-7 – volume: 73 start-page: 1787 year: 2009 ident: 10.1016/j.jdiacomp.2023.108564_bb0455 article-title: HSP40 ameliorates impairment of insulin secretion by inhibiting huntingtin aggregation in a HD pancreatic beta cell model publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.90147 – volume: 119 start-page: 1201 year: 2009 ident: 10.1016/j.jdiacomp.2023.108564_bb0245 article-title: GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice publication-title: J Clin Invest doi: 10.1172/JCI37007 – volume: 6 start-page: 174 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0210 article-title: JNK at the crossroad of obesity, insulin resistance, and cell stress response publication-title: Mol Metab doi: 10.1016/j.molmet.2016.12.001 – volume: 1864 start-page: 3805 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0110 article-title: Type 2 diabetes – an autoinflammatory disease driven by metabolic stress publication-title: Biochim Biophys Acta Mol Basis Dis doi: 10.1016/j.bbadis.2018.08.034 – volume: 23 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0350 article-title: Heat shock protein 60 restricts release of mitochondrial dsRNA to suppress hepatic inflammation and ameliorate non-alcoholic fatty liver disease in mice publication-title: Int J Mol Sci – volume: 2015 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0265 article-title: The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management publication-title: Mediators Inflamm doi: 10.1155/2015/249205 – volume: 126 start-page: 739 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0255 article-title: Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro publication-title: Clin Sci (Lond) doi: 10.1042/CS20130678 – volume: 20 start-page: 198 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0545 article-title: Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study publication-title: BMC Cardiovasc Disord doi: 10.1186/s12872-020-01456-7 – volume: 67 start-page: 1014 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0605 article-title: Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance publication-title: J Gerontol A doi: 10.1093/gerona/gls008 – volume: 297 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0430 article-title: GRP75 mediates endoplasmic reticulum-mitochondria coupling during palmitate-induced pancreatic β-cell apoptosis publication-title: J Biol Chem doi: 10.1016/j.jbc.2021.101368 – volume: 27 start-page: 523 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0585 article-title: Increased eHSP70-to-iHSP70 ratio in prediabetic and diabetic postmenopausal women: a biomarker of cardiometabolic risk publication-title: Cell Stress Chaperones doi: 10.1007/s12192-022-01288-8 – volume: 89 start-page: 1055 year: 2000 ident: 10.1016/j.jdiacomp.2023.108564_bb0655 article-title: HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise publication-title: J Appl Physiol (1985) doi: 10.1152/jappl.2000.89.3.1055 – volume: 156 start-page: 33 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0675 article-title: Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice publication-title: Biochimie. doi: 10.1016/j.biochi.2018.09.011 – start-page: 7 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0085 article-title: Extracellular HSPs: the complicated roles of extracellular HSPs in immunity publication-title: Front Immunol – volume: 111 start-page: 180 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0640 article-title: Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training publication-title: Exp Gerontol doi: 10.1016/j.exger.2018.07.014 – volume: 15 start-page: 11 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0295 article-title: Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance publication-title: Nutr Metab (Lond) doi: 10.1186/s12986-018-0242-6 – volume: 63 start-page: 1881 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0220 article-title: Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance publication-title: Diabetes. doi: 10.2337/db13-0967 – volume: 8 start-page: 178 year: 2009 ident: 10.1016/j.jdiacomp.2023.108564_bb0405 article-title: Proteins associated with immunopurified granules from a model pancreatic islet beta-cell system: proteomic snapshot of an endocrine secretory granule publication-title: J Proteome Res doi: 10.1021/pr800675k – volume: 432 start-page: 3033 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0070 article-title: Conditional disorder in small heat-shock proteins publication-title: J Mol Biol doi: 10.1016/j.jmb.2020.02.003 – volume: 316 start-page: E305 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0200 article-title: Impact of hepatic HSP72 on insulin signaling publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00215.2018 – volume: 1 start-page: 97 year: 1996 ident: 10.1016/j.jdiacomp.2023.108564_bb0050 article-title: Discovery of the heat shock response publication-title: Cell Stress Chaperones doi: 10.1379/1466-1268(1996)001<0097:DOTHSR>2.3.CO;2 – volume: 15 start-page: 959 year: 2010 ident: 10.1016/j.jdiacomp.2023.108564_bb0140 article-title: Increased serum HSP70 levels are associated with the duration of diabetes publication-title: Cell Stress Chaperones doi: 10.1007/s12192-010-0204-z – volume: 596 start-page: 4831 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0685 article-title: Passive heat therapy protects against endothelial cell hypoxia-reoxygenation via effects of elevations in temperature and circulating factors publication-title: J Physiol doi: 10.1113/JP276559 – volume: 96 start-page: 355 year: 2006 ident: 10.1016/j.jdiacomp.2023.108564_bb0660 article-title: Effect of concentric or eccentric weight training on the expression of heat shock proteins in m. biceps brachii of very well trained males publication-title: Eur J Appl Physiol doi: 10.1007/s00421-005-0084-6 – volume: 2010 year: 2010 ident: 10.1016/j.jdiacomp.2023.108564_bb0095 article-title: Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis publication-title: Mediators Inflamm doi: 10.1155/2010/453892 – volume: 76 start-page: 91 year: 2011 ident: 10.1016/j.jdiacomp.2023.108564_bb0040 article-title: The heat shock response: systems biology of proteotoxic stress in aging and disease publication-title: Cold Spring Harb Symp Quant Biol doi: 10.1101/sqb.2012.76.010637 – volume: 8 start-page: 595 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0230 article-title: Mitochondria-associated ER membranes - the origin site of autophagy publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2020.00595 – volume: 580 start-page: 2311 year: 2006 ident: 10.1016/j.jdiacomp.2023.108564_bb0490 article-title: Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic β-cell death under hyperglycemic conditions publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.03.043 – volume: 7 start-page: 23072 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0495 article-title: The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction publication-title: Oncotarget. doi: 10.18632/oncotarget.8604 – volume: 280 start-page: 847 year: 2005 ident: 10.1016/j.jdiacomp.2023.108564_bb0730 article-title: Involvement of endoplasmic reticulum stress in insulin resistance and diabetes publication-title: J Biol Chem doi: 10.1074/jbc.M411860200 – volume: 67 start-page: 291 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0175 article-title: Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle publication-title: IUBMB Life doi: 10.1002/iub.1370 – volume: 2017 start-page: 8379327 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0105 article-title: Diabetes-induced reactive oxygen species: mechanism of their generation and role in renal injury publication-title: J Diabetes Res doi: 10.1155/2017/8379327 – volume: 9 start-page: 193 year: 2008 ident: 10.1016/j.jdiacomp.2023.108564_bb0030 article-title: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2327 – volume: 11 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0515 article-title: Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards publication-title: eLife. doi: 10.7554/eLife.71862 – volume: 7 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0555 article-title: Heat shock protein 70 gene single nucleotide polymorphism and diabetic foot ulcer. Is there any relationship? publication-title: J Clin Med doi: 10.3390/jcm7080187 – volume: 55 Suppl 2 start-page: S9 year: 2006 ident: 10.1016/j.jdiacomp.2023.108564_bb0215 article-title: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction publication-title: Diabetes. doi: 10.2337/db06-S002 – volume: 287 start-page: 6266 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0445 article-title: Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells publication-title: J Biol Chem doi: 10.1074/jbc.M111.331264 – volume: 9 start-page: 423 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0155 article-title: Increased circulation and adipose tissue levels of DNAJC27/RBJ in obesity and type 2-diabetes publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2018.00423 – volume: 292 start-page: 3016 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0320 article-title: Heat shock protein 90 modulates lipid homeostasis by regulating the stability and function of sterol regulatory element-binding protein (SREBP) and SREBP cleavage-activating protein publication-title: J Biol Chem doi: 10.1074/jbc.M116.767277 – volume: 21 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0025 article-title: Pathophysiology of type 2 diabetes mellitus publication-title: Int J Mol Sci doi: 10.3390/ijms21176275 – volume: 21 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0035 article-title: Are heat shock proteins an important link between type 2 diabetes and Alzheimer disease? publication-title: Int J Mol Sci doi: 10.3390/ijms21218204 – volume: 63 start-page: 3279 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0235 article-title: Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance publication-title: Diabetes. doi: 10.2337/db13-1751 – volume: 294 start-page: R1600 year: 2008 ident: 10.1016/j.jdiacomp.2023.108564_bb0625 article-title: Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasma publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00581.2007 – volume: 86 start-page: 37 year: 2008 ident: 10.1016/j.jdiacomp.2023.108564_bb0305 article-title: A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates publication-title: Biochem Cell Biol doi: 10.1139/O07-154 – volume: 26 start-page: 42 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0620 article-title: Elevating body termperature to reduce low-grade inflammation: a welcome strategy for those unable to exercise? publication-title: Exerc Immunol Rev – volume: 21 start-page: 714 year: 2010 ident: 10.1016/j.jdiacomp.2023.108564_bb0420 article-title: PERK in beta cell biology and insulin biogenesis publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2010.08.005 – volume: 37 start-page: 683 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0560 article-title: Significance of functional GRP78 polymorphisms in predicting the onset of type 2 diabetic peripheral neuropathy in Chinese population publication-title: Neurol Res doi: 10.1179/1743132815Y.0000000054 – volume: 226 start-page: 156 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0240 article-title: GRP78: a cell’s response to stress publication-title: Life Sci doi: 10.1016/j.lfs.2019.04.022 – volume: 373 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0610 article-title: Exercise, heat shock proteins and insulin resistance publication-title: Philos Trans R Soc Lond B Biol Sci doi: 10.1098/rstb.2016.0529 – volume: 277 start-page: 45770 year: 2002 ident: 10.1016/j.jdiacomp.2023.108564_bb0500 article-title: Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification publication-title: J Biol Chem doi: 10.1074/jbc.M207485200 – volume: 36 start-page: 357 year: 1992 ident: 10.1016/j.jdiacomp.2023.108564_bb0595 article-title: Polymorphic analysis of the three MHC-linked HSP70 genes publication-title: Immunogenetics. doi: 10.1007/BF00218042 – volume: 22 start-page: 1183 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0600 article-title: The association between heat shock protein P2/P2 genotype with Egyptian hepatocellular carcinoma patients publication-title: Comp Clin Pathol doi: 10.1007/s00580-012-1547-x – volume: 50 start-page: 752 year: 2007 ident: 10.1016/j.jdiacomp.2023.108564_bb0465 article-title: Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes publication-title: Diabetologia. doi: 10.1007/s00125-006-0590-z – volume: 123 start-page: 4667 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0335 article-title: Leptin regulation of Hsp60 impacts hypothalamic insulin signaling publication-title: J Clin Invest doi: 10.1172/JCI67615 – volume: 61 start-page: 10 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0160 article-title: The expression of CCN2, IQSEC, RSPO1, DNAJC15, RIPK2, IL13RA2, IRS1, and IRS2 genes in blood of obese boys with insulin resistance publication-title: Fiziol Zh (1994) doi: 10.15407/fz61.01.010 – volume: 61 start-page: 615 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0360 article-title: Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance publication-title: Diabetes. doi: 10.2337/db10-1574 – volume: 184 start-page: 455 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0485 article-title: DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes publication-title: Eur J Endocrinol doi: 10.1530/EJE-20-0636 – volume: 4 start-page: 292 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0680 article-title: The effect of passive heating on heat shock protein 70 and interleukin-6: a possible treatment tool for metabolic diseases? publication-title: Temperature (Austin) doi: 10.1080/23328940.2017.1288688 – volume: 64 start-page: 67 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0355 article-title: Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis publication-title: J Mol Endocrinol doi: 10.1530/JME-19-0207 – start-page: 20 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0015 article-title: Genetics, adaptation to environmental changes and archaic admixture in the pathogenesis of diabetes mellitus in Indigenous Australians publication-title: Rev Endocr Metab Disord – volume: 5 start-page: 747 year: 2014 ident: 10.1016/j.jdiacomp.2023.108564_bb0020 article-title: Is the present cut-point to define type 2 diabetes appropriate in Latin-Americans? publication-title: World J Diabetes doi: 10.4239/wjd.v5.i6.747 – volume: 10 start-page: 345 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0520 article-title: Novel biomarkers for prediabetes, diabetes, and associated complications publication-title: Diabetes Metab Syndr Obes doi: 10.2147/DMSO.S100074 – volume: 18 start-page: 1 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0190 article-title: Emerging role of nitric oxide and heat shock proteins in insulin resistance publication-title: Curr Hypertens Rep doi: 10.1007/s11906-015-0615-4 – volume: 19 start-page: 4 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0060 article-title: Regulation of heat shock transcription factors and their roles in physiology and disease publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm.2017.73 – volume: 24 start-page: 69 year: 2019 ident: 10.1016/j.jdiacomp.2023.108564_bb0260 article-title: Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein publication-title: Cell Stress Chaperones doi: 10.1007/s12192-018-0942-x – volume: 125 start-page: 2008 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0695 article-title: Acute and chronic effects of hot water immersion on inflammation and metabolism in sedentary, overweight adults publication-title: J Appl Physiol (1985) doi: 10.1152/japplphysiol.00407.2018 – volume: 20 start-page: 174 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0525 article-title: Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis publication-title: BMC Endocr Disord doi: 10.1186/s12902-020-00653-x – volume: 125 start-page: 1447 year: 2018 ident: 10.1016/j.jdiacomp.2023.108564_bb0690 article-title: Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle publication-title: J Appl Physiol (1985) doi: 10.1152/japplphysiol.00383.2018 – volume: 10 year: 2022 ident: 10.1016/j.jdiacomp.2023.108564_bb0540 article-title: Extracellular Hsp90α, which participates in vascular inflammation, is a novel serum predictor of atherosclerosis in type 2 diabetes publication-title: BMJ Open Diabetes Res Care doi: 10.1136/bmjdrc-2021-002579 – volume: 10 start-page: 126 year: 2006 ident: 10.1016/j.jdiacomp.2023.108564_bb0440 article-title: Discovery of the ‘porosome’ the universal secretory machinery in cells publication-title: J Cell Mol Med doi: 10.1111/j.1582-4934.2006.tb00294.x – volume: 43 start-page: 250 year: 2012 ident: 10.1016/j.jdiacomp.2023.108564_bb0575 article-title: Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein 70 genes with type 2 diabetes publication-title: Lab Med doi: 10.1309/LM1LE9TNGIJFD7PS – volume: 11 start-page: 208 year: 2006 ident: 10.1016/j.jdiacomp.2023.108564_bb0590 article-title: Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes publication-title: Cell Stress Chaperones doi: 10.1379/CSC-184R.1 – volume: 14 start-page: 291 year: 2009 ident: 10.1016/j.jdiacomp.2023.108564_bb0185 article-title: Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys publication-title: Cell Stress Chaperones doi: 10.1007/s12192-008-0084-7 – volume: 53 start-page: 621 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0450 article-title: Potential role of Hsp90 in rat islet function under the condition of high glucose publication-title: Acta Diabetol doi: 10.1007/s00592-016-0852-2 – volume: 5 start-page: 194 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0100 article-title: Advanced glycation end products and oxidative stress in type 2 diabetes mellitus publication-title: Biomolecules. doi: 10.3390/biom5010194 – volume: 50(suppl_1):S169-S year: 2001 ident: 10.1016/j.jdiacomp.2023.108564_bb0115 article-title: Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function? publication-title: Diabetes. – volume: 100 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0130 article-title: Levels of circulating GRP78 and CHOP in endoplasmic reticulum stress pathways in Chinese type 2 diabetic kidney disease patients publication-title: Medicine (Baltimore) doi: 10.1097/MD.0000000000026879 – volume: 29 start-page: 578 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0550 article-title: Decreased expression of heat shock proteins may lead to compromised wound healing in type 2 diabetes mellitus patients publication-title: J Diabetes Complications doi: 10.1016/j.jdiacomp.2015.01.007 – start-page: 107 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0090 article-title: Chapter 5 - metabolic stress, heat shock proteins, and innate immune response – volume: 21 start-page: 783 year: 2016 ident: 10.1016/j.jdiacomp.2023.108564_bb0635 article-title: Effect of resistance exercise training on expression of Hsp70 and inflammatory cytokines in skeletal muscle and adipose tissue of STZ-induced diabetic rats publication-title: Cell Stress Chaperones doi: 10.1007/s12192-016-0703-7 – volume: 99 start-page: 15920 year: 2002 ident: 10.1016/j.jdiacomp.2023.108564_bb0470 article-title: Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.252341799 – volume: 64 start-page: 2892 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0475 article-title: Antioxidants complement the requirement for protein chaperone function to maintain β-cell function and glucose homeostasis publication-title: Diabetes. doi: 10.2337/db14-1357 – volume: 1853 start-page: 3192 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0250 article-title: Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2015.09.009 – volume: 89 start-page: 1067 year: 1997 ident: 10.1016/j.jdiacomp.2023.108564_bb0505 article-title: Daxx, a novel Fas-binding protein that activates JNK and apoptosis publication-title: Cell. doi: 10.1016/S0092-8674(00)80294-9 – volume: 172 start-page: 4303 year: 2015 ident: 10.1016/j.jdiacomp.2023.108564_bb0705 article-title: Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target publication-title: Br J Pharmacol doi: 10.1111/bph.13209 – volume: 10 start-page: 72 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0065 article-title: Recent advances in understanding the role of proteostasis publication-title: Fac Rev doi: 10.12703/r/10-72 – volume: 10 year: 2021 ident: 10.1016/j.jdiacomp.2023.108564_bb0410 article-title: The unfolded protein response: an overview publication-title: Biology (Basel) – volume: 8 year: 2013 ident: 10.1016/j.jdiacomp.2023.108564_bb0055 article-title: DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise publication-title: PloS One doi: 10.1371/journal.pone.0069217 – volume: 69 start-page: 623 year: 2017 ident: 10.1016/j.jdiacomp.2023.108564_bb0530 article-title: NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients publication-title: IUBMB Life doi: 10.1002/iub.1645 – volume: 11 start-page: 3360 year: 2020 ident: 10.1016/j.jdiacomp.2023.108564_bb0285 article-title: Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation publication-title: Nat Commun doi: 10.1038/s41467-020-16991-2 – volume: 105 start-page: 1739 year: 2008 ident: 10.1016/j.jdiacomp.2023.108564_bb0165 article-title: HSP72 protects against obesity-induced insulin resistance publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0705799105 – volume: 52 start-page: 102 year: 2003 ident: 10.1016/j.jdiacomp.2023.108564_bb0375 article-title: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes publication-title: Diabetes. doi: 10.2337/diabetes.52.1.102 |
| SSID | ssj0006551 |
| Score | 2.4057395 |
| SecondaryResourceType | review_article |
| Snippet | Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 108564 |
| SubjectTerms | Apoptosis Cytokines Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Genes Heat shock protein Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Homeostasis HSP70 HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Hyperglycemia Insulin Insulin resistance Kinases Metabolism Molecular Chaperones Musculoskeletal system Pathogenesis Pathophysiology Phosphorylation Physiology Stress Transcription factors Type 2 diabetes mellitus |
| Title | The role of heat shock proteins (HSPs) in type 2 diabetes mellitus pathophysiology |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1056872723001629 https://www.ncbi.nlm.nih.gov/pubmed/37852076 https://www.proquest.com/docview/2885557675 https://www.proquest.com/docview/2879407340 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1LT-MwEB4BlRAXxPLasl1kJA5wCDiJ7bgntItAFRII8ZB6sxLHFq3YBEj7_3cmj8IFOCe2rBn7G894Zj6AQ-G5QqvLEf1iFYhEZ8HQhZJyGtCZCGXuHdUOX9-o0aO4GstxG3Cr2rTKDhNroM5LSzHy00hrKSW1Hjl7eQ2INYpeV1sKjWXoUesySulKxguHC61rTb9I5PJ46qPkQ4Xw9GSK8qe07RMiEKdUO6nEZ8bps8tnbYQuN2C9vT2yP426f8CSKzZh9bp9H9-CO9Q6o4RBVnpGMMuqJwQ8VndjmBQVOxrd31bHbFIwir2yiHWxV_aPOnPO5hUjjuKyDnjUEfdteLy8eDgfBS1rQmCFDGeBtkLZzHutQq90zFOHVhkNvefa8QwdlniY5zi1FNkwy3yYpsKJYei85R4V4-MdWCnKwv0E5oSPnPWap9wLn6jU-dChh2PDOE9sqvogO3EZ27YUJ2aLZ9Pljk1NJ2ZDYjaNmPtwuhj30jTV-HZE0mnDdCWjCHIGcf_bkYNOeaY9npV530x9OFh8xoNFryVp4co5_YNQhQAoeB92G6UvFhsnWkY8UXtfT_4L1mglTeniAFZmb3P3G-8ws2y_3qj70Pt7cXN79x-dl_D_ |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrQS9oPLsQgEjgQSHtE5iO94DQjxabWl3VZVW6s0kji26gqSQXSH-VH8jM0m8cCk99ZzYsmbG3zw8D4AXwnOFWpcj-qUqEpkuopGLJeU0oDMRy9I7qh2eTNX4RHw6lacrcBFqYSitMmBiC9RlbSlGvp1oLaWk1iNvz39ENDWKXlfDCI1OLPbd71_osjVv9j4if18mye7O8Ydx1E8ViKyQ8TzSVihbeK9V7JVOee5Qa6Ei9Fw7XqBBn47KMi-cFMWoKHyc58KJUey85R4P7lPc9wasihRdmQGsvt-ZHh4tsV_JduAjjbNHnEmyf2qSZ1sz5Dglim_RyHJK7pNKXKYOLzN3W7W3uw63e3uVvesE7A6suOou3Jz0L_L34AjljFGKIqs9I2BnzVeEWNb2fzirGvZq_Pmwec3OKkbRXpawEO1l36kX6HzRMJqKXLchljbGfx9OroWiD2BQ1ZXbAOaET5z1mufcC5-p3PnYoU9l47TMbK6GIAO5jO2bmNMsjW8mZKvNTCCzITKbjsxD2F6uO-_aeFy5IgvcMKFIFWHVoKa5cuVmYJ7pAaExf8V3CM-Xn_Eq0_tMXrl6Qf8gOCLkCj6Ehx3Tl4dNMy0TnqlH_9_8GdwaH08OzMHedP8xrNGpusLJTRjMfy7cE7Sg5sXTXmwZfLnum_IHjxYwGQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIlVcEG8WChgJJDikayd-ZA8IIcpqS2lVAZX25iaOLbqCpJBdIf4av46ZJF64lJ56Tmwl8_hmPJ4HwDMZuEaryxH9Mp1Ik5fJxAtFOQ14mBCqCp5qhw8O9exYvp-r-Qb8jrUwlFYZMbED6qpxFCMfp3mulKLWI-MwpEUc7U5fn31PaIIU3bTGcRq9iOz7Xz_x-Na-2ttFXj9P0-m7z29nyTBhIHFSiWWSO6ldGUKuRdB5xguPFgyNYuC55yU699mkqorSK1lOyjKIopBeToQPjgf8iZDhvlfgqsmUIB0z8_VhDy17N_qRBtsj4qTmn-rkxc4CeU8p4zs0vJzS_JSW5xnG8xzfzgBOb8D1wXNlb3pRuwkbvr4FWwfD3fxt-IgSxyhZkTWBEcSz9guCLes6QZzWLXsx-3TUvmSnNaO4L0tZjPuyb9QVdLlqGc1HbrpgSxftvwPHl0LPu7BZN7W_D8zLkHoXcl7wIIPRhQ_C4-nKiawyrtAjUJFc1g3tzGmqxlcb89YWNpLZEpltT-YRjNfrzvqGHheuMJEbNparIsBatDkXrtyOzLMDNLT2ryCP4On6MSo13dQUtW9W9A7CJIKv5CO41zN9_bGZyVXKjX7w_82fwBbqh_2wd7j_EK7RR_UVlNuwufyx8o_QlVqWjzuZZXBy2UryB0Z2Muk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+role+of+heat+shock+proteins+%28HSPs%29+in+type+2+diabetes+mellitus+pathophysiology&rft.jtitle=Journal+of+diabetes+and+its+complications&rft.au=Esmaeilzadeh%2C+Abdolreza&rft.au=Mohammadi%2C+Vahid&rft.au=Elahi%2C+Reza&rft.au=Rezakhani%2C+Negin&rft.date=2023-11-01&rft.pub=Elsevier+Limited&rft.issn=1056-8727&rft.eissn=1873-460X&rft.volume=37&rft.issue=11&rft_id=info:doi/10.1016%2Fj.jdiacomp.2023.108564&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1056-8727&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1056-8727&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1056-8727&client=summon |