Traffic of p24 Proteins and COPII Coat Composition Mutually Influence Membrane Scaffolding

• Published in: Current biology Vol. 25; no. 10; pp. 1296 - 1305
• Main Authors: D’Arcangelo, Jennifer G., Crissman, Jonathan, Pagant, Silvere, Čopič, Alenka, Latham, Catherine F., Snapp, Erik L., Miller, Elizabeth A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 18.05.2015
• Subjects: Amino Acid Sequence; Cell Membrane - metabolism; COP-Coated Vesicles - chemistry; COP-Coated Vesicles - metabolism; Endoplasmic Reticulum - metabolism; Golgi Apparatus - metabolism; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Molecular Sequence Data; Nuclear Pore Complex Proteins - genetics; Nuclear Pore Complex Proteins - metabolism; Protein Transport; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - metabolism

Eukaryotic protein secretion requires efficient and accurate delivery of diverse secretory and membrane proteins. This process initiates in the ER, where vesicles are sculpted by the essential COPII coat. The Sec13p subunit of the COPII coat contributes to membrane scaffolding, which enforces curvat...