Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens

• Published in: The Tohoku Journal of Experimental Medicine Vol. 264; no. 4; pp. 203 - 213
• Main Authors: Miyauchi, Toshiya, Narita, Shintaro, Saiki, Yuriko, Kudo-Asabe, Yukitsugu, Horii, Akira, Fukushige, Shinichi, Habuchi, Tomonori, Nanjo, Hiroshi, Goto, Akiteru
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 2024
• Subjects: Aged; Biopsy, Needle; CARD Signaling Adaptor Proteins; Humans; Immunohistochemistry; Inflammasomes - metabolism; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasome; Prostate - pathology; Prostate - surgery; prostate cancer; Prostatectomy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; PYCARD; tissue specimens; PYCARD; prostate cancer; immunohistochemistry; NLRP3 inflammasome; tissue specimens

The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 rad...