Role of C-X-C motif chemokine ligand 14 promoter region DNA methylation and single nucleotide polymorphism in influenza A severity

• Published in: Respiratory medicine Vol. 185; p. 106462
• Main Authors: Chen, Liang, Lei, Yan, Zhang, Lingling
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2021
• Subjects: A549 Cells; C-X-C motif Chemokine ligand 14; Chemokines, CXC - genetics; Chemokines, CXC - metabolism; Chemokines, CXC - physiology; DNA methylation; DNA Methylation - genetics; Gene Expression - genetics; Gene Expression Regulation, Viral - genetics; Genotype; Humans; Influenza A; Influenza A Virus, H1N1 Subtype - genetics; Influenza, Human - genetics; Influenza, Human - immunology; Influenza, Human - virology; Ligands; Lymphocyte Count; Patient Acuity; Polymorphism, Single Nucleotide - genetics; Promoter Regions, Genetic - genetics; Single nucleotide polymorphism; SNP genotyping; T-Lymphocytes - immunology; DNA methylation; Influenza A; Single nucleotide polymorphism; C-X-C motif Chemokine ligand 14; SNP genotyping

The purpose of our experiment is to discuss the function of DNA methylation and single nucleotide polymorphism (SNP) in C-X-C motif chemokine ligand 14 (CXCL14) promoter region in influenza A (H1N1) severity. Clinic data and blood samples from H1N1 patients were collected. Blood routine indexes were...