The Identification of Blood Biomarkers of Chronic Neuropathic Pain by Comparative Transcriptomics

• Published in: Neuromolecular medicine Vol. 24; no. 3; pp. 320 - 338
• Main Authors: Islam, Barira, Stephenson, John, Young, Bethan, Manca, Maurizio, Buckley, David A., Radford, Helen, Zis, Panagiotis, Johnson, Mark I., Finn, David P., McHugh, Patrick C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2022; Springer Nature B.V
• Subjects: Biomarkers; Biomedical and Life Sciences; Biomedicine; Chronic pain; Comparative analysis; DNA microarrays; Gene expression; Internal Medicine; Myc protein; Neuralgia; Neurology; Neurosciences; Original Paper; Pain; Pain perception; Potassium channels (inwardly-rectifying); Stat1 protein; TLR4 protein; Toll-like receptors; Transcriptomics; Biomarkers; Affymetrix microarray; Inflammation; AUROC curve analysis; Neuropathic; Chronic pain

In this study, we recruited 50 chronic pain (neuropathic and nociceptive) and 43 pain-free controls to identify specific blood biomarkers of chronic neuropathic pain (CNP). Affymetrix microarray was carried out on a subset of samples selected 10 CNP and 10 pain-free control participants. The most si...