Moricizine, an Antiarrhythmic Agent, as a Potent Inhibitor of Hepatic Microsomal CYP1A

• Published in: Pharmacology Vol. 66; no. 4; pp. 190 - 198
• Main Authors: Konishi, Hiroki, Morita, Kunihiko, Minouchi, Tokuzo, Yamaji, Akira
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.12.2002
• Subjects: Animals; Antiarrhythmics; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A1 - antagonists & inhibitors; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; Male; Mice; Microsomes, Liver; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Moricizine; Moricizine - pharmacology; Original Paper; Moricizine; Theophylline metabolism; CYP1A inhibitor; Mouse hepatic microsomes

We examined the inhibitory effect of moricizine (MOR) on hepatic cytochrome P-450 (CYP) in mice. Spectrophotometric analysis revealed that MOR had a relatively high affinity for CYP molecules. MOR most potently inhibited the CYP1A1-dependent ethoxyresorufin O-deethylation and the CYP1A2-dependent me...