Long-term biodistribution and biocompatibility investigation of dextran-coated magnetite nanoparticle using mice as the animal model

• Published in: Journal of biomedical nanotechnology Vol. 8; no. 2; p. 301
• Main Authors: Estevanato, Luciana L C, Lacava, Leandro M, Carvalho, Luis C F, Azevedo, Ricardo B, Silva, Osni, Pelegrini, Fernando, Báo, Sônia N, Morais, Paulo C, Lacava, Zulmira G M
• Format: Journal Article
• Language: English
• Published: United States 01.04.2012
• Subjects: Animals; Dextrans - chemistry; Dextrans - pharmacokinetics; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Female; Histocytochemistry; Injections, Intravenous; Liver - metabolism; Magnetic Resonance Spectroscopy; Magnetite Nanoparticles - chemistry; Mice; Microscopy, Electron; Models, Animal; Particle Size; Photomicrography; Spleen - metabolism; Tissue Distribution

Magnetic resonance is used to investigate biodistribution aspects of dextran-coated magnetite nanoparticles (9.4 nm core diameter) in both liver and spleen from 5 minutes up to 6 months after intravenous administration of a magnetic fluid sample in female Swiss mice. Using magnetic resonance data im...