Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration

• Published in: Life (Basel, Switzerland) Vol. 11; no. 7; p. 635
• Main Authors: Hu, Monica L., Quinn, Joel, Xue, Kanmin
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.06.2021; MDPI
• Subjects: Age; Age related diseases; age-related macular degeneration; Alzheimer's disease; amyloid-beta; Apolipoprotein E; Apolipoprotein E4; Apolipoproteins; Atrophy; Cell activation; Complement activation; drusen; Environmental stress; Epithelium; Eye diseases; High fat diet; Immune system; Inflammation; Lipid metabolism; Lipids; Macular degeneration; Neurodegenerative diseases; Pathogenesis; Retina; retinal inflammation; Review; Risk analysis; Risk factors; Risk management

Age-related macular degeneration (AMD) is a multifactorial retinal disorder that is a major global cause of severe visual impairment. The development of an effective therapy to treat geographic atrophy, the predominant form of AMD, remains elusive due to the incomplete understanding of its pathogene...