ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance
Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs. MDR severely hinders the effective treatment of cancer and is the major cause of chemotherapy failure. ATP-binding cassette (A...
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| Published in | Drug resistance updates Vol. 66; p. 100905 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Scotland
Elsevier Ltd
01.01.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1368-7646 1532-2084 1532-2084 |
| DOI | 10.1016/j.drup.2022.100905 |
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| Abstract | Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs. MDR severely hinders the effective treatment of cancer and is the major cause of chemotherapy failure. ATP-binding cassette (ABC) transporters are extensively expressed in various body tissues, and actively transport endogenous and exogenous substrates through biological membranes. Overexpression of ABC transporters is frequently observed in MDR cancer cells, which promotes efflux of chemotherapeutic drugs and reduces their intracellular accumulation. Increasing evidence suggests that ABC transporters regulate tumor immune microenvironment (TIME) by transporting various cytokines, thus controlling anti-tumor immunity and sensitivity to anticancer drugs. On the other hand, the expression of various ABC transporters is regulated by cytokines and other immune signaling molecules. Targeted inhibition of ABC transporter expression or function can enhance the efficacy of immune checkpoint inhibitors by promoting anticancer immune microenvironment. This review provides an update on the recent research progress in this field. |
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| AbstractList | Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs. MDR severely hinders the effective treatment of cancer and is the major cause of chemotherapy failure. ATP-binding cassette (ABC) transporters are extensively expressed in various body tissues, and actively transport endogenous and exogenous substrates through biological membranes. Overexpression of ABC transporters is frequently observed in MDR cancer cells, which promotes efflux of chemotherapeutic drugs and reduces their intracellular accumulation. Increasing evidence suggests that ABC transporters regulate tumor immune microenvironment (TIME) by transporting various cytokines, thus controlling anti-tumor immunity and sensitivity to anticancer drugs. On the other hand, the expression of various ABC transporters is regulated by cytokines and other immune signaling molecules. Targeted inhibition of ABC transporter expression or function can enhance the efficacy of immune checkpoint inhibitors by promoting anticancer immune microenvironment. This review provides an update on the recent research progress in this field. Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs. MDR severely hinders the effective treatment of cancer and is the major cause of chemotherapy failure. ATP-binding cassette (ABC) transporters are extensively expressed in various body tissues, and actively transport endogenous and exogenous substrates through biological membranes. Overexpression of ABC transporters is frequently observed in MDR cancer cells, which promotes efflux of chemotherapeutic drugs and reduces their intracellular accumulation. Increasing evidence suggests that ABC transporters regulate tumor immune microenvironment (TIME) by transporting various cytokines, thus controlling anti-tumor immunity and sensitivity to anticancer drugs. On the other hand, the expression of various ABC transporters is regulated by cytokines and other immune signaling molecules. Targeted inhibition of ABC transporter expression or function can enhance the efficacy of immune checkpoint inhibitors by promoting anticancer immune microenvironment. This review provides an update on the recent research progress in this field.Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs. MDR severely hinders the effective treatment of cancer and is the major cause of chemotherapy failure. ATP-binding cassette (ABC) transporters are extensively expressed in various body tissues, and actively transport endogenous and exogenous substrates through biological membranes. Overexpression of ABC transporters is frequently observed in MDR cancer cells, which promotes efflux of chemotherapeutic drugs and reduces their intracellular accumulation. Increasing evidence suggests that ABC transporters regulate tumor immune microenvironment (TIME) by transporting various cytokines, thus controlling anti-tumor immunity and sensitivity to anticancer drugs. On the other hand, the expression of various ABC transporters is regulated by cytokines and other immune signaling molecules. Targeted inhibition of ABC transporter expression or function can enhance the efficacy of immune checkpoint inhibitors by promoting anticancer immune microenvironment. This review provides an update on the recent research progress in this field. |
| ArticleNumber | 100905 |
| Author | Fu, Liwu To, Kenneth Kin Wah Chen, Zhe-Sheng Fan, Jingyi |
| Author_xml | – sequence: 1 givenname: Jingyi surname: Fan fullname: Fan, Jingyi organization: State Key Laboratory of Oncology in South China；Collaborative Innovation Center for Cancer Medicine, Guangdong Esophageal Cancer Institute; Sun Yat-sen University Cancer Center, Guangzhou 510060, China – sequence: 2 givenname: Kenneth Kin Wah surname: To fullname: To, Kenneth Kin Wah organization: School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China – sequence: 3 givenname: Zhe-Sheng surname: Chen fullname: Chen, Zhe-Sheng email: chenz@stjohns.edu organization: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, United States – sequence: 4 givenname: Liwu surname: Fu fullname: Fu, Liwu email: Fulw@mail.sysu.edu.cn organization: State Key Laboratory of Oncology in South China；Collaborative Innovation Center for Cancer Medicine, Guangdong Esophageal Cancer Institute; Sun Yat-sen University Cancer Center, Guangzhou 510060, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36463807$$D View this record in MEDLINE/PubMed |
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| Keywords | TAM ABC TAP Targeted therapy Tumor immune microenvironment MHC NBD NF-κB HGNC TGF-β MDR BCRP MRP1 Multidrug resistance VEGF TIME TMD iTregs IL-1β EMT IL-6 IL-10 P-glycoprotein TNF-α IL-17 TILs ABC transporter ATP DC |
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| SubjectTerms | ABC transporter Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Cytokines Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm Humans Immunotherapy Multidrug resistance Neoplasms - drug therapy Neoplasms - genetics P-glycoprotein Targeted therapy Tumor immune microenvironment Tumor Microenvironment |
| Title | ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance |
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