PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

• Published in: Cancer cell Vol. 23; no. 3; pp. 287 - 301
• Main Authors: Vazquez, Francisca, Lim, Ji-Hong, Chim, Helen, Bhalla, Kavita, Girnun, Geoff, Pierce, Kerry, Clish, Clary B., Granter, Scott R., Widlund, Hans R., Spiegelman, Bruce M., Puigserver, Pere
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.03.2013
• Subjects: Animals; Apoptosis; Cell Line, Tumor; Energy Metabolism; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; HEK293 Cells; Humans; Melanocytes - metabolism; Melanoma - metabolism; Mice; Microphthalmia-Associated Transcription Factor - metabolism; Mitochondria - metabolism; Oxidative Stress; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species - metabolism; RNA Interference; RNA, Small Interfering; Transcription Factors - genetics; Transcription Factors - metabolism

Cancer cells reprogram their metabolism using different strategies to meet energy and anabolic demands to maintain growth and survival. Understanding the molecular and genetic determinants of these metabolic programs is critical to successfully exploit them for therapy. Here, we report that the onco...