Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and -9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2

• Published in: Thrombosis research Vol. 115; no. 3; pp. 205 - 210
• Main Authors: Tayebjee, Muzahir H., Lip, Gregory Y.H., Blann, Andrew D., MacFadyen, Robert J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 2005; Elsevier Science
• Subjects: Adult; African Continental Ancestry Group - ethnology; Age; Asian Continental Ancestry Group - ethnology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Circadian Rhythm; Coronary heart disease; Cross-Sectional Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Diurnal variation; Enzyme-Linked Immunosorbent Assay; Ethnicity; European Continental Ancestry Group - ethnology; Exercise; Exercise Test; Extracellular matrix; Female; Gender; Heart; Humans; Male; Matrix Metalloproteinase 2 - blood; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinases; Medical sciences; Pharmacology. Drug treatments; Tissue inhibitor of metalloproteinase; Tissue Inhibitor of Metalloproteinase-1 - blood; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tissue Inhibitor of Metalloproteinase-2 - blood; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Vasodilator agents. Cerebral vasodilators; Ethnicity; Matrix metalloproteinases; Exercise; Tissue inhibitor of metalloproteinase; Extracellular matrix; Gender; Diurnal variation; Age; Physical exercise; Myocardial infarction; Metalloendopeptidases; Cardiovascular disease; Myocardial disease; Vascular disease; Heart disease; Interstitial collagenase; Human; Enzyme; Ethnic group; Gelatinase B; Stress; Gelatinase A; Peptidases; Treatment; Hydrolases; Chinese

Background: Circulating metalloproteinases (MMP) and their inhibitors (TIMP) are indices of vascular and cardiac tissue matrix turnover. However, the temporal changes and relationship of these parameters to age, gender, ethnicity and exercise have been poorly defined. We therefore studied these aspe...