Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia

It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variati...

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Published inNPJ schizophrenia Vol. 8; no. 1; p. 91
Main Authors Yuan, Liu, Ma, Xiaoqian, Li, David, Ouyang, Lijun, Fan, Lejia, Li, Chunwang, He, Ying, Chen, Xiaogang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 04.11.2022
Nature Publishing Group
Subjects
692/53
692/699/476/1799
Brain
Cognitive Psychology
Medicine
Medicine & Public Health
Neurology
Neurosciences
Psychiatry
Schizophrenia
Online AccessGet full text
ISSN2754-6993
2754-6993
2334-265X
DOI10.1038/s41537-022-00305-0

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Abstract It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variation, we found a widespread brain functional network (frame network) in healthy people( n  = 380, two datasets from public databases). We then explored the alterations in a medicated group (60 subjects with schizophrenia vs 71 matched controls) and a drug-naive first-episode group (68 subjects with schizophrenia vs 45 matched controls). A linear support vector classifier (SVC) was constructed to distinguish patients and controls using the medicated patients’ frame network. We found most frame connections of healthy people had high strength, which were symmetrical and connected the left and right hemispheres. Conversely, significant differences in frame connections were observed in both patient groups, which were positively correlated with negative symptoms (mainly language dysfunction). Additionally, patients’ frame network were more left-lateralized, concentrating on the left frontal lobe, and was quite accurate at distinguishing medicated patients from controls (classifier accuracy was 78.63%, sensitivity was 86.67%, specificity was 76.06%, and the area under the curve (AUC) was 0.83). Furthermore, the results were repeated in the drug-naive set (accuracy was 84.96%, sensitivity was 85.29%, specificity was 88.89%, and AUC was 0.93). These findings indicate that the abnormal pattern of frame network in subjects with schizophrenia might provide new insights into the dysconnectivity in schizophrenia.
AbstractList It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variation, we found a widespread brain functional network (frame network) in healthy people(n = 380, two datasets from public databases). We then explored the alterations in a medicated group (60 subjects with schizophrenia vs 71 matched controls) and a drug-naive first-episode group (68 subjects with schizophrenia vs 45 matched controls). A linear support vector classifier (SVC) was constructed to distinguish patients and controls using the medicated patients' frame network. We found most frame connections of healthy people had high strength, which were symmetrical and connected the left and right hemispheres. Conversely, significant differences in frame connections were observed in both patient groups, which were positively correlated with negative symptoms (mainly language dysfunction). Additionally, patients' frame network were more left-lateralized, concentrating on the left frontal lobe, and was quite accurate at distinguishing medicated patients from controls (classifier accuracy was 78.63%, sensitivity was 86.67%, specificity was 76.06%, and the area under the curve (AUC) was 0.83). Furthermore, the results were repeated in the drug-naive set (accuracy was 84.96%, sensitivity was 85.29%, specificity was 88.89%, and AUC was 0.93). These findings indicate that the abnormal pattern of frame network in subjects with schizophrenia might provide new insights into the dysconnectivity in schizophrenia.It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variation, we found a widespread brain functional network (frame network) in healthy people(n = 380, two datasets from public databases). We then explored the alterations in a medicated group (60 subjects with schizophrenia vs 71 matched controls) and a drug-naive first-episode group (68 subjects with schizophrenia vs 45 matched controls). A linear support vector classifier (SVC) was constructed to distinguish patients and controls using the medicated patients' frame network. We found most frame connections of healthy people had high strength, which were symmetrical and connected the left and right hemispheres. Conversely, significant differences in frame connections were observed in both patient groups, which were positively correlated with negative symptoms (mainly language dysfunction). Additionally, patients' frame network were more left-lateralized, concentrating on the left frontal lobe, and was quite accurate at distinguishing medicated patients from controls (classifier accuracy was 78.63%, sensitivity was 86.67%, specificity was 76.06%, and the area under the curve (AUC) was 0.83). Furthermore, the results were repeated in the drug-naive set (accuracy was 84.96%, sensitivity was 85.29%, specificity was 88.89%, and AUC was 0.93). These findings indicate that the abnormal pattern of frame network in subjects with schizophrenia might provide new insights into the dysconnectivity in schizophrenia.
It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variation, we found a widespread brain functional network (frame network) in healthy people( n  = 380, two datasets from public databases). We then explored the alterations in a medicated group (60 subjects with schizophrenia vs 71 matched controls) and a drug-naive first-episode group (68 subjects with schizophrenia vs 45 matched controls). A linear support vector classifier (SVC) was constructed to distinguish patients and controls using the medicated patients’ frame network. We found most frame connections of healthy people had high strength, which were symmetrical and connected the left and right hemispheres. Conversely, significant differences in frame connections were observed in both patient groups, which were positively correlated with negative symptoms (mainly language dysfunction). Additionally, patients’ frame network were more left-lateralized, concentrating on the left frontal lobe, and was quite accurate at distinguishing medicated patients from controls (classifier accuracy was 78.63%, sensitivity was 86.67%, specificity was 76.06%, and the area under the curve (AUC) was 0.83). Furthermore, the results were repeated in the drug-naive set (accuracy was 84.96%, sensitivity was 85.29%, specificity was 88.89%, and AUC was 0.93). These findings indicate that the abnormal pattern of frame network in subjects with schizophrenia might provide new insights into the dysconnectivity in schizophrenia.
It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the human brain and whether they change in schizophrenia is still a question. By setting 1% connections with the smallest coefficient of variation, we found a widespread brain functional network (frame network) in healthy people(n = 380, two datasets from public databases). We then explored the alterations in a medicated group (60 subjects with schizophrenia vs 71 matched controls) and a drug-naive first-episode group (68 subjects with schizophrenia vs 45 matched controls). A linear support vector classifier (SVC) was constructed to distinguish patients and controls using the medicated patients’ frame network. We found most frame connections of healthy people had high strength, which were symmetrical and connected the left and right hemispheres. Conversely, significant differences in frame connections were observed in both patient groups, which were positively correlated with negative symptoms (mainly language dysfunction). Additionally, patients’ frame network were more left-lateralized, concentrating on the left frontal lobe, and was quite accurate at distinguishing medicated patients from controls (classifier accuracy was 78.63%, sensitivity was 86.67%, specificity was 76.06%, and the area under the curve (AUC) was 0.83). Furthermore, the results were repeated in the drug-naive set (accuracy was 84.96%, sensitivity was 85.29%, specificity was 88.89%, and AUC was 0.93). These findings indicate that the abnormal pattern of frame network in subjects with schizophrenia might provide new insights into the dysconnectivity in schizophrenia.
ArticleNumber 91
Author Ouyang, Lijun
Fan, Lejia
Chen, Xiaogang
Li, David
He, Ying
Li, Chunwang
Yuan, Liu
Ma, Xiaoqian
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  organization: Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health
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Cites_doi 10.1177/1073858416667720
10.1080/1357650X.2011.626561
10.1007/s11065-014-9248-7
10.1007/s00406-011-0242-2
10.1146/annurev-genet-112414-055322
10.1002/mrm.1910350312
10.1016/j.neubiorev.2016.06.030
10.1038/s41586-018-0642-9
10.1006/nimg.1998.0384
10.1093/cercor/bhaa207
10.1016/j.pnpbp.2013.09.012
10.1016/j.biopsych.2013.06.016
10.1016/j.biopsych.2017.06.013
10.1016/B978-0-444-53497-2.00054-1
10.1016/j.eswa.2018.07.039
10.1016/j.pscychresns.2005.05.005
10.1016/j.neuroimage.2016.10.038
10.1093/schbul/sby112
10.1093/schbul/sbx034
10.1038/nature14178
10.1016/j.neubiorev.2017.03.018
10.3389/fnhum.2013.00464
10.1038/nrn3214
10.1016/j.nbd.2019.03.002
10.1523/JNEUROSCI.3784-12.2013
10.1016/j.schres.2010.07.027
10.1016/j.biopsych.2010.12.012
10.1016/j.neuroimage.2012.04.062
10.1007/s10334-018-00732-0
10.3389/fpsyt.2021.679642
10.1073/pnas.1912064117
10.1093/cercor/bhaa335
10.1016/j.neubiorev.2010.11.004
10.1038/nrn2201
10.3389/fnbeh.2021.668520
10.1016/j.neuroimage.2010.07.036
10.1176/appi.ajp.2020.20030340
10.1523/JNEUROSCI.3539-11.2011
10.1016/j.molmed.2013.10.008
10.1016/j.nicl.2013.06.008
10.1016/B978-0-12-804281-6.00010-0
10.3758/BF03192966
10.1097/HRP.0000000000000102
10.1016/j.neuroimage.2015.05.046
10.1093/ijnp/pyx095
10.1016/j.schres.2006.12.028
10.1073/pnas.1203593109
10.1073/pnas.1513302113
10.1146/annurev-neuro-071013-014030
10.1007/s11682-018-9935-8
10.1038/nn.4576
10.1001/jamapsychiatry.2013.1328
10.1016/j.tics.2011.08.003
10.1016/j.neuroimage.2016.02.022
10.1016/j.neuron.2011.12.014
10.1523/JNEUROSCI.2177-15.2016
10.1192/bjp.167.2.197
10.1038/nn.4502
10.1016/j.schres.2006.03.013
10.1016/j.pnpbp.2018.05.020
10.1016/j.biopsych.2006.11.027
10.1073/pnas.1324118111
10.1523/JNEUROSCI.20-06-j0003.2000
10.1016/j.pneurobio.2016.11.002
10.1016/0896-6273(95)90280-5
10.1016/j.biopsych.2018.06.007
10.1016/j.neuroimage.2013.04.081
10.1002/hbm.21333
10.1037/t15169-000
10.1093/schbul/13.2.261
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References Nigam (CR18) 2016; 36
Zhong, He, Shu, Gong (CR32) 2017; 27
Economo (CR52) 2018; 563
Duboc, Dufourcq, Blader, Roussigne (CR29) 2015; 49
van den Heuvel, Fornito (CR25) 2014; 24
Dora, Agrawal, Panda, Abraham (CR72) 2018; 114
Varoquaux (CR73) 2017; 145
Zhao (CR15) 2021; 31
Friston (CR67) 1996; 35
van den Heuvel (CR23) 2013; 70
Wolford, Miller, Gazzaniga (CR60) 2000; 20
Fulcher, Fornito (CR11) 2016; 113
Li, Chen, Guo, Gerfen, Svoboda (CR51) 2015; 519
Kelley (CR69) 2007; 39
Garrison, Scheinost, Finn, Shen, Constable (CR4) 2015; 118
Postema, De Marco, Colato, Venneri (CR7) 2019; 32
Bassett, Sporns (CR3) 2017; 20
Malatesta, Marzoli, Prete, Tommasi (CR33) 2021; 15
Curcic-Blake (CR39) 2017; 148
Ball (CR16) 2014; 111
Gazzaniga (CR59) 1995; 14
van Erp (CR47) 2014; 75
Kikinis (CR43) 2010; 123
Brandler, Paracchini (CR34) 2014; 20
Harris (CR63) 2007; 62
Hare (CR10) 2019; 45
Coyle, Balu, Puhl, Konopaske (CR27) 2016; 24
Lindell (CR55) 2013; 7
Makris (CR70) 1999; 9
Zhong (CR30) 2021; 31
van den Heuvel, Sporns (CR17) 2011; 31
Zhang (CR37) 2019; 13
Fox, Raichle (CR1) 2007; 8
Linden (CR2) 2012; 73
Xie (CR35) 2018; 86
Pettersson-Yeo, Allen, Benetti, Mcguire, Mechelli (CR42) 2011; 35
Bassett, Bullmore (CR14) 2017; 23
Towlson, Vertes, Ahnert, Schafer, Bullmore (CR20) 2013; 33
Zhou (CR46) 2005; 139
Craddock, James, Holtzheimer, Hu, Mayberg (CR71) 2012; 33
Miyata (CR9) 2019; 131
Davey, Pujol, Harrison (CR6) 2016; 132
Yan, Craddock, Zuo, Zang, Milham (CR68) 2013; 80
Gal (CR12) 2017; 20
Dong, Wang, Chang, Luo, Yao (CR26) 2018; 44
Price (CR54) 2012; 62
Schmitt, Hasan, Gruber, Falkai (CR28) 2011; 261
Vigneau (CR57) 2011; 54
Goel (CR58) 2019; 163
Raichle (CR8) 2015; 38
Guo (CR38) 2013; 2
Du (CR61) 2019; 85
Palaniyappan, Mallikarjun, Joseph, White, Liddle (CR62) 2011; 69
Bullmore, Sporns (CR21) 2012; 13
Kraguljac (CR41) 2021; 178
Schroder, Wenz, Schad, Baudendistel, Knopp (CR44) 1995; 167
van den Heuvel, Kahn, Goni, Sporns (CR19) 2012; 109
Alexander-Bloch (CR31) 2020; 117
Menon (CR5) 2011; 15
Cattaneo (CR50) 2013; 116
Collin, Scholtens, Kahn, Hillegers, van den Heuvel (CR24) 2017; 82
Hertrich, Dietrich, Ackermann (CR53) 2016; 68
Qiu (CR48) 2021; 12
CR22
Ocklenburg, Strockens, Gunturkun (CR56) 2013; 18
CR65
CR64
Liao, Vasilakos, He (CR13) 2017; 77
Salgado-Pineda (CR49) 2007; 91
Guo (CR36) 2014; 48
Yan (CR66) 2010; 4
Liu (CR40) 2018; 21
Exner, Weniger, Schmidt-Samoa, Irle (CR45) 2006; 84
K Kelley (305_CR69) 2007; 39
MP van den Heuvel (305_CR17) 2011; 31
V Goel (305_CR58) 2019; 163
305_CR22
WM Brandler (305_CR34) 2014; 20
305_CR64
305_CR65
X Qiu (305_CR48) 2021; 12
Y Liu (305_CR40) 2018; 21
AF Alexander-Bloch (305_CR31) 2020; 117
G Malatesta (305_CR33) 2021; 15
C Exner (305_CR45) 2006; 84
I Hertrich (305_CR53) 2016; 68
AK Lindell (305_CR55) 2013; 7
MP van den Heuvel (305_CR19) 2012; 109
D Dong (305_CR26) 2018; 44
S Zhong (305_CR30) 2021; 31
JT Coyle (305_CR27) 2016; 24
MD Fox (305_CR1) 2007; 8
DS Bassett (305_CR3) 2017; 20
MP van den Heuvel (305_CR25) 2014; 24
X Du (305_CR61) 2019; 85
G Ball (305_CR16) 2014; 111
N Makris (305_CR70) 1999; 9
MS Gazzaniga (305_CR59) 1995; 14
W Pettersson-Yeo (305_CR42) 2011; 35
KA Garrison (305_CR4) 2015; 118
L Cattaneo (305_CR50) 2013; 116
S Guo (305_CR38) 2013; 2
Yan (305_CR66) 2010; 4
G Varoquaux (305_CR73) 2017; 145
TG van Erp (305_CR47) 2014; 75
RC Craddock (305_CR71) 2012; 33
X Liao (305_CR13) 2017; 77
L Dora (305_CR72) 2018; 114
NV Kraguljac (305_CR41) 2021; 178
S Nigam (305_CR18) 2016; 36
J Schroder (305_CR44) 1995; 167
S Ocklenburg (305_CR56) 2013; 18
J Miyata (305_CR9) 2019; 131
EK Towlson (305_CR20) 2013; 33
E Bullmore (305_CR21) 2012; 13
DEJ Linden (305_CR2) 2012; 73
N Li (305_CR51) 2015; 519
M Vigneau (305_CR57) 2011; 54
V Menon (305_CR5) 2011; 15
G Collin (305_CR24) 2017; 82
P Salgado-Pineda (305_CR49) 2007; 91
CG Yan (305_CR68) 2013; 80
E Gal (305_CR12) 2017; 20
DS Bassett (305_CR14) 2017; 23
BD Fulcher (305_CR11) 2016; 113
S Zhao (305_CR15) 2021; 31
W Xie (305_CR35) 2018; 86
Y Zhang (305_CR37) 2019; 13
Z Kikinis (305_CR43) 2010; 123
ME Raichle (305_CR8) 2015; 38
A Schmitt (305_CR28) 2011; 261
V Duboc (305_CR29) 2015; 49
MC Postema (305_CR7) 2019; 32
MP van den Heuvel (305_CR23) 2013; 70
MN Economo (305_CR52) 2018; 563
S Zhong (305_CR32) 2017; 27
B Curcic-Blake (305_CR39) 2017; 148
SY Zhou (305_CR46) 2005; 139
L Palaniyappan (305_CR62) 2011; 69
KJWS Friston (305_CR67) 1996; 35
CG Davey (305_CR6) 2016; 132
CJ Price (305_CR54) 2012; 62
JM Harris (305_CR63) 2007; 62
W Guo (305_CR36) 2014; 48
G Wolford (305_CR60) 2000; 20
SM Hare (305_CR10) 2019; 45
References_xml – volume: 23
  start-page: 499
  year: 2017
  end-page: 516
  ident: CR14
  article-title: Small-world brain networks revisited
  publication-title: Neuroscientist
  doi: 10.1177/1073858416667720
– ident: CR22
– volume: 18
  start-page: 1
  year: 2013
  end-page: 31
  ident: CR56
  article-title: Lateralisation of conspecific vocalisation in non-human vertebrates
  publication-title: Laterality
  doi: 10.1080/1357650X.2011.626561
– volume: 24
  start-page: 32
  year: 2014
  end-page: 48
  ident: CR25
  article-title: Brain networks in schizophrenia
  publication-title: Neuropsychol. Rev.
  doi: 10.1007/s11065-014-9248-7
– volume: 261
  start-page: S150
  year: 2011
  end-page: S154
  ident: CR28
  article-title: Schizophrenia as a disorder of disconnectivity
  publication-title: Eur. Arch. Psychiatry Clin. Neurosci.
  doi: 10.1007/s00406-011-0242-2
– volume: 49
  start-page: 647
  year: 2015
  end-page: 672
  ident: CR29
  article-title: Asymmetry of the brain: development and implications
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev-genet-112414-055322
– volume: 35
  start-page: 346
  year: 1996
  end-page: 355
  ident: CR67
  article-title: Movement_x0002_related effects in fMRI time-series
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1910350312
– volume: 68
  start-page: 602
  year: 2016
  end-page: 610
  ident: CR53
  article-title: The role of the supplementary motor area for speech and language processing
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2016.06.030
– volume: 563
  start-page: 79
  year: 2018
  end-page: 84
  ident: CR52
  article-title: Distinct descending motor cortex pathways and their roles in movement
  publication-title: Nature
  doi: 10.1038/s41586-018-0642-9
– volume: 9
  start-page: 18
  year: 1999
  end-page: 45
  ident: CR70
  article-title: MRI-Based topographic parcellation of human cerebral white matter and nuclei II. Rationale and applications with systematics of cerebral connectivity
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0384
– volume: 31
  start-page: 77
  year: 2021
  end-page: 88
  ident: CR30
  article-title: Interhemispheric relationship of genetic influence on human brain connectivity
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhaa207
– volume: 48
  start-page: 14
  year: 2014
  end-page: 19
  ident: CR36
  article-title: Decreased resting-state interhemispheric coordination in first-episode, drug-naive paranoid schizophrenia
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2013.09.012
– volume: 75
  start-page: 398
  year: 2014
  end-page: 405
  ident: CR47
  article-title: Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2013.06.016
– volume: 82
  start-page: 746
  year: 2017
  end-page: 755
  ident: CR24
  article-title: Affected anatomical rich club and Structural-Functional coupling in young offspring of schizophrenia and bipolar disorder patients
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2017.06.013
– volume: 116
  start-page: 681
  year: 2013
  end-page: 691
  ident: CR50
  article-title: Language
  publication-title: Handb. Clin. Neurol.
  doi: 10.1016/B978-0-444-53497-2.00054-1
– volume: 114
  start-page: 313
  year: 2018
  end-page: 321
  ident: CR72
  article-title: Nested cross-validation based adaptive sparse representation algorithm and its application to pathological brain classification
  publication-title: Expert Syst. Appl.
  doi: 10.1016/j.eswa.2018.07.039
– volume: 139
  start-page: 127
  year: 2005
  end-page: 139
  ident: CR46
  article-title: Volumetric analysis of sulci/gyri-defined in vivo frontal lobe regions in schizophrenia: precentral gyrus, cingulate gyrus, and prefrontal region
  publication-title: Psychiatry Res.
  doi: 10.1016/j.pscychresns.2005.05.005
– volume: 145
  start-page: 166
  year: 2017
  end-page: 179
  ident: CR73
  article-title: Assessing and tuning brain decoders: cross-validation, caveats, and guidelines
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.10.038
– volume: 45
  start-page: 892
  year: 2019
  end-page: 901
  ident: CR10
  article-title: Salience-default mode functional network connectivity linked to positive and negative symptoms of schizophrenia
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sby112
– volume: 44
  start-page: 168
  year: 2018
  end-page: 181
  ident: CR26
  article-title: Dysfunction of large-scale brain networks in schizophrenia: a meta-analysis of resting-state functional connectivity
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbx034
– volume: 519
  start-page: 51
  year: 2015
  end-page: 56
  ident: CR51
  article-title: A motor cortex circuit for motor planning and movement
  publication-title: Nature
  doi: 10.1038/nature14178
– volume: 77
  start-page: 286
  year: 2017
  end-page: 300
  ident: CR13
  article-title: Small-world human brain networks: perspectives and challenges
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.03.018
– volume: 7
  start-page: 464
  year: 2013
  ident: CR55
  article-title: Continuities in emotion lateralization in human and non-human primates
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2013.00464
– volume: 13
  start-page: 336
  year: 2012
  end-page: 349
  ident: CR21
  article-title: The economy of brain network organization
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3214
– volume: 131
  start-page: 104414
  year: 2019
  ident: CR9
  article-title: Toward integrated understanding of salience in psychosis
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2019.03.002
– volume: 33
  start-page: 6380
  year: 2013
  end-page: 6387
  ident: CR20
  article-title: The rich club of the neuronal connectome
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3784-12.2013
– volume: 123
  start-page: 153
  year: 2010
  end-page: 159
  ident: CR43
  article-title: Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2010.07.027
– volume: 69
  start-page: 974
  year: 2011
  end-page: 979
  ident: CR62
  article-title: Folding of the prefrontal cortex in schizophrenia: Regional differences in gyrification
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.12.012
– ident: CR64
– volume: 62
  start-page: 816
  year: 2012
  end-page: 847
  ident: CR54
  article-title: A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.04.062
– volume: 32
  start-page: 391
  year: 2019
  end-page: 405
  ident: CR7
  article-title: A study of within-subject reliability of the brain’s default-mode network
  publication-title: MAGMA
  doi: 10.1007/s10334-018-00732-0
– volume: 12
  start-page: 679642
  year: 2021
  ident: CR48
  article-title: The relationship between abnormal resting-state functional connectivity of the left superior frontal gyrus and cognitive impairments in youth-onset drug-naive schizophrenia
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2021.679642
– volume: 117
  start-page: 7430
  year: 2020
  end-page: 7436
  ident: CR31
  article-title: Imaging local genetic influences on cortical folding
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1912064117
– volume: 31
  start-page: 1987
  year: 2021
  end-page: 1997
  ident: CR15
  article-title: Sex differences in anatomical rich-club and structural-functional coupling in the human brain network
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhaa335
– volume: 35
  start-page: 1110
  year: 2011
  end-page: 1124
  ident: CR42
  article-title: Dysconnectivity in schizophrenia: where are we now?
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2010.11.004
– volume: 8
  start-page: 700
  year: 2007
  end-page: 711
  ident: CR1
  article-title: Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2201
– volume: 15
  start-page: 668520
  year: 2021
  ident: CR33
  article-title: Human lateralization, maternal effects and neurodevelopmental disorders
  publication-title: Front. Behav. Neurosci.
  doi: 10.3389/fnbeh.2021.668520
– volume: 54
  start-page: 577
  year: 2011
  end-page: 593
  ident: CR57
  article-title: What is right-hemisphere contribution to phonological, lexico-semantic, and sentence processing? Insights from a meta-analysis
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2010.07.036
– volume: 178
  start-page: 509
  year: 2021
  end-page: 521
  ident: CR41
  article-title: Neuroimaging biomarkers in schizophrenia
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2020.20030340
– volume: 31
  start-page: 15775
  year: 2011
  end-page: 15786
  ident: CR17
  article-title: Rich-club organization of the human connectome
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3539-11.2011
– volume: 20
  start-page: 83
  year: 2014
  end-page: 90
  ident: CR34
  article-title: The genetic relationship between handedness and neurodevelopmental disorders
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2013.10.008
– volume: 2
  start-page: 818
  year: 2013
  end-page: 826
  ident: CR38
  article-title: Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression
  publication-title: Neuroimage Clin.
  doi: 10.1016/j.nicl.2013.06.008
– volume: 163
  start-page: 179
  year: 2019
  end-page: 196
  ident: CR58
  article-title: Hemispheric asymmetry in the prefrontal cortex for complex cognition
  publication-title: Handb. Clin. Neurol.
  doi: 10.1016/B978-0-12-804281-6.00010-0
– volume: 39
  start-page: 755
  year: 2007
  end-page: 766
  ident: CR69
  article-title: Sample size planning for the coefficient of variation from the accuracy in parameter estimation approach
  publication-title: Behav. Res. Methods
  doi: 10.3758/BF03192966
– volume: 24
  start-page: 80
  year: 2016
  end-page: 86
  ident: CR27
  article-title: History of the concept of disconnectivity in schizophrenia
  publication-title: Harv. Rev. Psychiatry
  doi: 10.1097/HRP.0000000000000102
– volume: 118
  start-page: 651
  year: 2015
  end-page: 661
  ident: CR4
  article-title: The (in)stability of functional brain network measures across thresholds
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2015.05.046
– volume: 21
  start-page: 33
  year: 2018
  end-page: 41
  ident: CR40
  article-title: Decreased resting-state interhemispheric functional connectivity correlated with neurocognitive deficits in drug-naive first-episode adolescent-onset schizophrenia
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1093/ijnp/pyx095
– volume: 27
  start-page: 2560
  year: 2017
  end-page: 2570
  ident: CR32
  article-title: Developmental changes in topological asymmetry between hemispheric brain white matter networks from adolescence to young adulthood
  publication-title: Cereb. Cortex
– volume: 91
  start-page: 73
  year: 2007
  end-page: 81
  ident: CR49
  article-title: Schizophrenia and frontal cortex: where does it fail?
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2006.12.028
– volume: 4
  start-page: 13
  year: 2010
  ident: CR66
  article-title: DPARSF: A MATLAB toolbox for “pipeline” data analysis of resting-state fMRI
  publication-title: Front. Syst. Neurosci.
– volume: 109
  start-page: 11372
  year: 2012
  end-page: 11377
  ident: CR19
  article-title: High-cost, high-capacity backbone for global brain communication
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1203593109
– volume: 113
  start-page: 1435
  year: 2016
  end-page: 1440
  ident: CR11
  article-title: A transcriptional signature of hub connectivity in the mouse connectome
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1513302113
– volume: 38
  start-page: 433
  year: 2015
  end-page: 447
  ident: CR8
  article-title: The brain’s default mode network
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-071013-014030
– volume: 13
  start-page: 1220
  year: 2019
  end-page: 1235
  ident: CR37
  article-title: Altered intra- and inter-hemispheric functional dysconnectivity in schizophrenia
  publication-title: Brain Imag. Behav.
  doi: 10.1007/s11682-018-9935-8
– ident: CR65
– volume: 20
  start-page: 1004
  year: 2017
  end-page: 1013
  ident: CR12
  article-title: Rich cell-type-specific network topology in neocortical microcircuitry
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4576
– volume: 70
  start-page: 783
  year: 2013
  end-page: 792
  ident: CR23
  article-title: Abnormal rich club organization and functional brain dynamics in schizophrenia
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.1328
– volume: 15
  start-page: 483
  year: 2011
  end-page: 506
  ident: CR5
  article-title: Large-scale brain networks and psychopathology: a unifying triple network model
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2011.08.003
– volume: 132
  start-page: 390
  year: 2016
  end-page: 397
  ident: CR6
  article-title: Mapping the self in the brain’s default mode network
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.02.022
– volume: 73
  start-page: 8
  year: 2012
  end-page: 22
  ident: CR2
  article-title: The challenges and promise of neuroimaging in psychiatry
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.12.014
– volume: 36
  start-page: 670
  year: 2016
  end-page: 684
  ident: CR18
  article-title: Rich-club organization in effective connectivity among cortical neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2177-15.2016
– volume: 167
  start-page: 197
  year: 1995
  end-page: 201
  ident: CR44
  article-title: Sensorimotor cortex and supplementary motor area changes in schizophrenia. A study with functional magnetic resonance imaging
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.167.2.197
– volume: 20
  start-page: 353
  year: 2017
  end-page: 364
  ident: CR3
  article-title: Network neuroscience
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4502
– volume: 84
  start-page: 386
  year: 2006
  end-page: 396
  ident: CR45
  article-title: Reduced size of the pre-supplementary motor cortex and impaired motor sequence learning in first-episode schizophrenia
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2006.03.013
– volume: 86
  start-page: 114
  year: 2018
  end-page: 121
  ident: CR35
  article-title: Functional brain lateralization in schizophrenia based on the variability of resting-state fMRI signal
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2018.05.020
– volume: 62
  start-page: 722
  year: 2007
  end-page: 729
  ident: CR63
  article-title: Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2006.11.027
– volume: 111
  start-page: 7456
  year: 2014
  end-page: 7461
  ident: CR16
  article-title: Rich-club organization of the newborn human brain
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1324118111
– volume: 20
  start-page: C64
  year: 2000
  ident: CR60
  article-title: The left hemisphere’s role in hypothesis formation
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-06-j0003.2000
– volume: 148
  start-page: 1
  year: 2017
  end-page: 20
  ident: CR39
  article-title: Interaction of language, auditory and memory brain networks in auditory verbal hallucinations
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2016.11.002
– volume: 14
  start-page: 217
  year: 1995
  end-page: 228
  ident: CR59
  article-title: Principles of human brain organization derived from split-brain studies
  publication-title: Neuron
  doi: 10.1016/0896-6273(95)90280-5
– volume: 85
  start-page: 49
  year: 2019
  end-page: 59
  ident: CR61
  article-title: Aberrant middle prefrontal-motor cortex connectivity mediates motor inhibitory biomarker in schizophrenia
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2018.06.007
– volume: 80
  start-page: 246
  year: 2013
  end-page: 262
  ident: CR68
  article-title: Standardizing the intrinsic brain: towards robust measurement of inter-individual variation in 1000 functional connectomes
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.04.081
– volume: 33
  start-page: 1914
  year: 2012
  end-page: 1928
  ident: CR71
  article-title: A whole brain fMRI atlas generated via spatially constrained spectral clustering
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.21333
– volume: 13
  start-page: 1220
  year: 2019
  ident: 305_CR37
  publication-title: Brain Imag. Behav.
  doi: 10.1007/s11682-018-9935-8
– volume: 178
  start-page: 509
  year: 2021
  ident: 305_CR41
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2020.20030340
– volume: 123
  start-page: 153
  year: 2010
  ident: 305_CR43
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2010.07.027
– volume: 519
  start-page: 51
  year: 2015
  ident: 305_CR51
  publication-title: Nature
  doi: 10.1038/nature14178
– volume: 116
  start-page: 681
  year: 2013
  ident: 305_CR50
  publication-title: Handb. Clin. Neurol.
  doi: 10.1016/B978-0-444-53497-2.00054-1
– volume: 132
  start-page: 390
  year: 2016
  ident: 305_CR6
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.02.022
– volume: 109
  start-page: 11372
  year: 2012
  ident: 305_CR19
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1203593109
– volume: 49
  start-page: 647
  year: 2015
  ident: 305_CR29
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev-genet-112414-055322
– volume: 33
  start-page: 1914
  year: 2012
  ident: 305_CR71
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.21333
– volume: 15
  start-page: 483
  year: 2011
  ident: 305_CR5
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2011.08.003
– volume: 32
  start-page: 391
  year: 2019
  ident: 305_CR7
  publication-title: MAGMA
  doi: 10.1007/s10334-018-00732-0
– volume: 9
  start-page: 18
  year: 1999
  ident: 305_CR70
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0384
– volume: 12
  start-page: 679642
  year: 2021
  ident: 305_CR48
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2021.679642
– volume: 24
  start-page: 32
  year: 2014
  ident: 305_CR25
  publication-title: Neuropsychol. Rev.
  doi: 10.1007/s11065-014-9248-7
– ident: 305_CR64
  doi: 10.1037/t15169-000
– volume: 44
  start-page: 168
  year: 2018
  ident: 305_CR26
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbx034
– volume: 84
  start-page: 386
  year: 2006
  ident: 305_CR45
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2006.03.013
– volume: 18
  start-page: 1
  year: 2013
  ident: 305_CR56
  publication-title: Laterality
  doi: 10.1080/1357650X.2011.626561
– volume: 35
  start-page: 1110
  year: 2011
  ident: 305_CR42
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2010.11.004
– volume: 20
  start-page: 1004
  year: 2017
  ident: 305_CR12
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4576
– volume: 62
  start-page: 816
  year: 2012
  ident: 305_CR54
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.04.062
– volume: 117
  start-page: 7430
  year: 2020
  ident: 305_CR31
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1912064117
– volume: 163
  start-page: 179
  year: 2019
  ident: 305_CR58
  publication-title: Handb. Clin. Neurol.
  doi: 10.1016/B978-0-12-804281-6.00010-0
– volume: 27
  start-page: 2560
  year: 2017
  ident: 305_CR32
  publication-title: Cereb. Cortex
– volume: 8
  start-page: 700
  year: 2007
  ident: 305_CR1
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2201
– volume: 73
  start-page: 8
  year: 2012
  ident: 305_CR2
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.12.014
– volume: 36
  start-page: 670
  year: 2016
  ident: 305_CR18
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2177-15.2016
– volume: 563
  start-page: 79
  year: 2018
  ident: 305_CR52
  publication-title: Nature
  doi: 10.1038/s41586-018-0642-9
– volume: 114
  start-page: 313
  year: 2018
  ident: 305_CR72
  publication-title: Expert Syst. Appl.
  doi: 10.1016/j.eswa.2018.07.039
– volume: 148
  start-page: 1
  year: 2017
  ident: 305_CR39
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2016.11.002
– volume: 13
  start-page: 336
  year: 2012
  ident: 305_CR21
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3214
– volume: 38
  start-page: 433
  year: 2015
  ident: 305_CR8
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-071013-014030
– volume: 20
  start-page: 353
  year: 2017
  ident: 305_CR3
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4502
– volume: 77
  start-page: 286
  year: 2017
  ident: 305_CR13
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.03.018
– volume: 21
  start-page: 33
  year: 2018
  ident: 305_CR40
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1093/ijnp/pyx095
– volume: 69
  start-page: 974
  year: 2011
  ident: 305_CR62
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2010.12.012
– volume: 31
  start-page: 77
  year: 2021
  ident: 305_CR30
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhaa207
– volume: 20
  start-page: C64
  year: 2000
  ident: 305_CR60
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.20-06-j0003.2000
– volume: 85
  start-page: 49
  year: 2019
  ident: 305_CR61
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2018.06.007
– volume: 113
  start-page: 1435
  year: 2016
  ident: 305_CR11
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1513302113
– volume: 139
  start-page: 127
  year: 2005
  ident: 305_CR46
  publication-title: Psychiatry Res.
  doi: 10.1016/j.pscychresns.2005.05.005
– volume: 75
  start-page: 398
  year: 2014
  ident: 305_CR47
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2013.06.016
– volume: 23
  start-page: 499
  year: 2017
  ident: 305_CR14
  publication-title: Neuroscientist
  doi: 10.1177/1073858416667720
– volume: 14
  start-page: 217
  year: 1995
  ident: 305_CR59
  publication-title: Neuron
  doi: 10.1016/0896-6273(95)90280-5
– volume: 131
  start-page: 104414
  year: 2019
  ident: 305_CR9
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2019.03.002
– volume: 86
  start-page: 114
  year: 2018
  ident: 305_CR35
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2018.05.020
– volume: 68
  start-page: 602
  year: 2016
  ident: 305_CR53
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2016.06.030
– volume: 31
  start-page: 1987
  year: 2021
  ident: 305_CR15
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhaa335
– volume: 20
  start-page: 83
  year: 2014
  ident: 305_CR34
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2013.10.008
– volume: 31
  start-page: 15775
  year: 2011
  ident: 305_CR17
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3539-11.2011
– volume: 82
  start-page: 746
  year: 2017
  ident: 305_CR24
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2017.06.013
– ident: 305_CR65
  doi: 10.1093/schbul/13.2.261
– volume: 54
  start-page: 577
  year: 2011
  ident: 305_CR57
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2010.07.036
– volume: 24
  start-page: 80
  year: 2016
  ident: 305_CR27
  publication-title: Harv. Rev. Psychiatry
  doi: 10.1097/HRP.0000000000000102
– volume: 91
  start-page: 73
  year: 2007
  ident: 305_CR49
  publication-title: Schizophr. Res.
  doi: 10.1016/j.schres.2006.12.028
– volume: 111
  start-page: 7456
  year: 2014
  ident: 305_CR16
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1324118111
– volume: 2
  start-page: 818
  year: 2013
  ident: 305_CR38
  publication-title: Neuroimage Clin.
  doi: 10.1016/j.nicl.2013.06.008
– volume: 4
  start-page: 13
  year: 2010
  ident: 305_CR66
  publication-title: Front. Syst. Neurosci.
– volume: 118
  start-page: 651
  year: 2015
  ident: 305_CR4
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2015.05.046
– volume: 80
  start-page: 246
  year: 2013
  ident: 305_CR68
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.04.081
– volume: 39
  start-page: 755
  year: 2007
  ident: 305_CR69
  publication-title: Behav. Res. Methods
  doi: 10.3758/BF03192966
– volume: 70
  start-page: 783
  year: 2013
  ident: 305_CR23
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.1328
– volume: 45
  start-page: 892
  year: 2019
  ident: 305_CR10
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sby112
– volume: 7
  start-page: 464
  year: 2013
  ident: 305_CR55
  publication-title: Front. Hum. Neurosci.
  doi: 10.3389/fnhum.2013.00464
– volume: 261
  start-page: S150
  year: 2011
  ident: 305_CR28
  publication-title: Eur. Arch. Psychiatry Clin. Neurosci.
  doi: 10.1007/s00406-011-0242-2
– ident: 305_CR22
– volume: 145
  start-page: 166
  year: 2017
  ident: 305_CR73
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.10.038
– volume: 167
  start-page: 197
  year: 1995
  ident: 305_CR44
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.167.2.197
– volume: 48
  start-page: 14
  year: 2014
  ident: 305_CR36
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2013.09.012
– volume: 35
  start-page: 346
  year: 1996
  ident: 305_CR67
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.1910350312
– volume: 15
  start-page: 668520
  year: 2021
  ident: 305_CR33
  publication-title: Front. Behav. Neurosci.
  doi: 10.3389/fnbeh.2021.668520
– volume: 33
  start-page: 6380
  year: 2013
  ident: 305_CR20
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3784-12.2013
– volume: 62
  start-page: 722
  year: 2007
  ident: 305_CR63
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2006.11.027
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Snippet It is widely accepted that there are some common network patterns in the human brain. However, the existence of stable and strong functional connections in the...
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692/699/476/1799
Brain
Cognitive Psychology
Medicine
Medicine & Public Health
Neurology
Neurosciences
Psychiatry
Schizophrenia
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Title Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia
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