Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo

• Published in: Bone (New York, N.Y.) Vol. 172; p. 116780
• Main Authors: Walle, Matthias, Whittier, Danielle E., Schenk, Denis, Atkins, Penny R., Blauth, Michael, Zysset, Philippe, Lippuner, Kurt, Müller, Ralph, Collins, Caitlyn J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2023
• Subjects: Bone and Bones - diagnostic imaging; Bone biomechanics; Bone Density - physiology; Bone Remodeling; Bone Resorption - diagnostic imaging; High-resolution peripheral quantitative computed tomography; Humans; Mechanobiology; Mechanoregulation; Micro-finite element analysis; Osteogenesis; Radius - physiology; Repeatability; Reproducibility; Tomography, X-Ray Computed - methods; Repeatability; Micro-finite element analysis; Mechanoregulation; Reproducibility; Mechanobiology; High-resolution peripheral quantitative computed tomography; Bone biomechanics

Local mechanical stimuli in the bone microenvironment are essential for the homeostasis and adaptation of the skeleton, with evidence suggesting that disruption of the mechanically-driven bone remodelling process may lead to bone loss. Longitudinal clinical studies have shown the combined use of hig...