Immune signatures underlying post-acute COVID-19 lung sequelae

• Published in: Science immunology Vol. 6; no. 65; p. eabk1741
• Main Authors: Cheon, I S, Li, C, Son, Y M, Goplen, N P, Wu, Y, Cassmann, T, Wang, Z, Wei, X, Tang, J, Li, Y, Marlow, H, Hughes, S, Hammel, L, Cox, T M, Goddery, E, Ayasoufi, K, Weiskopf, D, Boonyaratanakornkit, J, Dong, H, Li, H, Chakraborty, R, Johnson, A J, Edell, E, Taylor, J J, Kaplan, M H, Sette, A, Bartholmai, B J, Kern, R, Vassallo, R, Sun, J
• Format: Journal Article
• Language: English
• Published: United States 12.11.2021
• Subjects: B-Lymphocytes - immunology; B-Lymphocytes - pathology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; COVID-19 - microbiology; COVID-19 - pathology; Female; Humans; Immunologic Memory; Lung - immunology; Lung - pathology; Lung - virology; Male; Middle Aged; SARS-CoV-2 - immunology

Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term pulmonary sequelae, but the underlying mechanisms or associated local and systemic immune correlates are not known. Here, we have performed high-dimensional characterization of the pathophysiological and immune tr...