The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A

• Published in: Biophysical journal Vol. 118; no. 1; pp. 262 - 272
• Main Authors: Guo, Shuai, Chen, Yafei F., Shi, Sai, Pang, Chunli L., Wang, Xuzhao Z., Zhang, Hailin L., Zhan, Yong, An, Hailong L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.01.2020; The Biophysical Society
• Subjects: Animals; Anoctamin-1 - chemistry; Anoctamin-1 - metabolism; Binding Sites; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Ginsenosides - chemistry; Ginsenosides - metabolism; Ginsenosides - pharmacology; Guinea Pigs; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Protein Conformation; Static Electricity

The calcium-activated chloride channel TMEM16A is involved in many physiological processes, and insufficient function of TMEM16A may lead to the occurrence of various diseases. Therefore, TMEM16A activators are supposed to be potentially useful for treatment of TMEM16A downregulation-inducing diseas...