Spheroid mechanics and implications for cell invasion

• Published in: Advances in physics: X Vol. 6; no. 1
• Main Authors: Boot, Ruben C., Koenderink, Gijsje H., Boukany, Pouyan E.
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 01.01.2021; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: active matter; Cancer; Cell adhesion; cell invasion; Cell sorting; Formability; Mathematical models; Mechanical properties; Mechanics; Mechanics (physics); mechanobiology; Metastasis; Parameters; Physiology; Spheroids; Surface tension; Three dimensional models; tissue mechanics; Viscoelasticity

Spheroids are widely used in vitro 3D multicellular model systems that mimic complex physiological microenvironments of tissues. As different cell types vary in deformability and adhesion, the choice of (heterogeneous) cell composition will define overall spheroid mechanics, including their viscoela...