Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway - Yamashita, Naoya; Kondo, Manami; Zhao, Shuai; Li, Wei; Koike, Kazuo; Nemoto, Kiyomitsu; Kanno, Yuichiro (Bioorganic & Medicinal Chemistry Letters, 2017)
Keywords: Alkaloids; Alkaloids - chemistry; Alkaloids - toxicity; Apoptosis; Apoptosis - drug effects; Breast cancer; Carbolines; Carbolines - chemistry; Carbolines - toxicity; Caspase; Caspase 3; Caspase 3 - metabolism; Cell Line, Tumor; Cell Survival; Cell Survival - drug effects; Epidermal growth factor receptor; ErbB Receptors; Female; G1 Phase Cell Cycle Checkpoints; G1 Phase Cell Cycle Checkpoints - drug effects; Humans; Interleukin-6; Interleukin-6 - pharmacology; Phosphorylation; Phosphorylation - drug effects; Poly(ADP-ribose) Polymerases; Poly(ADP-ribose) Polymerases - metabolism; Receptor, Epidermal Growth Factor - metabolism; Signal transducer and activator of transcription 3; Signal Transduction; Signal Transduction - drug effects; STAT3 Transcription Factor; STAT3 Transcription Factor - metabolism; Triple Negative Breast Neoplasms; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; Caspase; Breast cancer; Epidermal growth factor receptor; Signal transducer and activator of transcription 3; Apoptosis