Association between exposure to anaesthesia and surgery and long-term cognitive trajectories in older adults: report from the Mayo Clinic Study of Aging

• Published in: British journal of anaesthesia : BJA Vol. 121; no. 2; pp. 398 - 405
• Main Authors: Schulte, P.J., Roberts, R.O., Knopman, D.S., Petersen, R.C., Hanson, A.C., Schroeder, D.R., Weingarten, T.N., Martin, D.P., Warner, D.O., Sprung, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2018; Elsevier
• Subjects: Aged; Aged, 80 and over; Anesthesia - adverse effects; Anesthesia, General - adverse effects; cognitive ageing; cognitive domains; Cognitive Dysfunction - epidemiology; Cognitive Dysfunction - psychology; cognitive z-scores; Female; Follow-Up Studies; general anaesthesia; General Surgery - statistics & numerical data; Humans; Longitudinal Studies; Male; Memory; Neuropsychological Tests; Neuroscience and Neuroanaesthesia; older adults; Socioeconomic Factors; older adults; cognitive z-scores; cognitive ageing; cognitive domains; general anaesthesia

The link between exposure to general anaesthesia and surgery (exposure) and cognitive decline in older adults is debated. We hypothesised that it is associated with cognitive decline. We analysed the longitudinal cognitive function trajectory in a cohort of older adults. Models assessed the rate of...