Prepulse inhibition and P50 suppression: Commonalities and dissociations

• Published in: Psychiatry research Vol. 143; no. 2; pp. 147 - 158
• Main Authors: Oranje, Bob, Geyer, Mark A., Bocker, Koen B.E., Leon Kenemans, J., Verbaten, Marinus N.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.08.2006; Elsevier
• Subjects: Acoustic Stimulation; Adult; Attention - physiology; Auditory Perception - physiology; Biological and medical sciences; Brain Mapping; Cerebral Cortex - physiopathology; Cross-modal; Electroencephalography; Electromyography; Electrooculography; Evoked Potentials - physiology; Frontal Lobe - physiopathology; Humans; Inhibition (Psychology); Loudness Perception - physiology; Male; Medical sciences; N100; P50 suppression; Photic Stimulation; PPI; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reaction Time - physiology; Reflex, Startle - physiology; Schizophrenia - diagnosis; Schizophrenia - physiopathology; Sensory gating; Signal Processing, Computer-Assisted; Source localization; Visual Perception - physiology; PPI; P50 suppression; Sensory gating; Source localization; Cross-modal; N100; Dissociation; Localization; Intermodal perception; Gating; s: PPI; Prepulse inhibition

Patients with schizophrenia exhibit reduced levels of both prepulse inhibition of the startle reflex (PPI) and condition-test suppression of the P50 event-related potential. This study investigated the extent to which PPI and P50 suppression, which exhibit similar parametric sensitivities, are intri...