The role of FGF-2/HGF and fibronectin matrix on pleomorphic adenoma myoepithelial cell morphology and immunophenotype: an in vitro study

• Published in: Growth factors (Chur, Switzerland) Vol. 33; no. 1; pp. 50 - 56
• Main Authors: Silva, Carolina Amália Barcellos, Nardello, Laura Cristina Leite, Garcia, Frederico Windlin, Araújo, Ney Soares de, Montalli, Victor Angelo, Araújo, Vera Cavalcanti de, Martinez, Elizabeth Ferreira
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.02.2015; Informa Healthcare
• Subjects: Actins - immunology; Adenoma, Pleomorphic - immunology; Adenoma, Pleomorphic - pathology; Cell Proliferation; Cells, Cultured; Epithelial Cells - drug effects; Epithelial Cells - immunology; Epithelial Cells - pathology; Extracellular matrix; Fibroblast Growth Factor 2 - pharmacology; Fibronectins - pharmacology; growth factors; Hepatocyte Growth Factor - pharmacology; Humans; myoepithelial cells; Phenotype; Salivary Gland Neoplasms - immunology; Salivary Gland Neoplasms - pathology; tumor microenvironment; Extracellular matrix; myoepithelial cells; tumor microenvironment; growth factors

Abstract Myoepithelial cells play a central role in glandular tumors, regulating the progression of in situ to invasive neoplasias, with the tumor microenvironment being shown to be involved in both initiation and progression. This study aimed to analyze the in vitro effects of fibroblast growth fac...