Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 284; no. 1; pp. 26 - L38
• Main Authors: Parinandi, Narasimham L, Kleinberg, Michael A, Usatyuk, Peter V, Cummings, Rhett J, Pennathur, Arjun, Cardounel, Arturo J, Zweier, Jay L, Garcia, Joe G. N, Natarajan, Viswanathan
• Format: Journal Article
• Language: English
• Published: United States 01.01.2003
• Subjects: Antisense Elements (Genetics) - pharmacology; Cells, Cultured; Endothelium, Vascular - enzymology; Enzyme Activation - physiology; Enzyme Inhibitors - pharmacology; Humans; Hydrogen Peroxide - metabolism; Hyperoxia - enzymology; Hyperoxia - physiopathology; Membrane Transport Proteins; Mitogen-Activated Protein Kinases - physiology; NADPH Dehydrogenase - genetics; NADPH Oxidases - metabolism; NADPH Oxidases - physiology; Onium Compounds - pharmacology; Phagocytosis - physiology; Phosphoproteins - genetics; Pulmonary Artery - enzymology; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism

1  Division of Pulmonary and Critical Care Medicine and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore 21224; and 2  Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, Maryland 21201 Hyperoxia increases reacti...