Cell adhesion in cancer: Beyond the migration of single cells

• Published in: The Journal of biological chemistry Vol. 295; no. 8; pp. 2495 - 2505
• Main Authors: Janiszewska, Michalina, Primi, Marina Candido, Izard, Tina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2020; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; cadherin; cancer; cancer biology; cancer stem cells; Cell Adhesion; cell adhesion molecules; Cell Communication; Cell Movement; Cell Transformation, Neoplastic - pathology; collective migration; epithelial-mesenchymal transition; Humans; integrin; JBC Reviews; Neoplasms - pathology; organoids; targeted treatment; Tumor Microenvironment; cell adhesion molecules; cell adhesion; organoids; cadherin; cancer; cancer biology; epithelial-mesenchymal transition; cancer stem cells; integrin; collective migration; targeted treatment

Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-extracellular matrix interactions. For instance, normal epithelial cells maintain tissue structure by adhering to each other and to the extracellular matrix. The proteins that mediate these distinct interactions are...