A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation

• Published in: JACC. Heart failure Vol. 6; no. 10; pp. 874 - 883
• Main Authors: Abraham, William T., Kuck, Karl-Heinz, Goldsmith, Rochelle L., Lindenfeld, JoAnn, Reddy, Vivek Y., Carson, Peter E., Mann, Douglas L., Saville, Benjamin, Parise, Helen, Chan, Rodrigo, Wiegn, Phi, Hastings, Jeffrey L., Kaplan, Andrew J., Edelmann, Frank, Luthje, Lars, Kahwash, Rami, Tomassoni, Gery F., Gutterman, David D., Stagg, Angela, Burkhoff, Daniel, Hasenfuß, Gerd
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018
• Subjects: Electric Stimulation - adverse effects; Electric Stimulation - instrumentation; Electric Stimulation - methods; Electrodes, Implanted; Exercise Test; Exercise Tolerance; Female; heart failure; Heart Failure - mortality; Heart Failure - physiopathology; Heart Failure - therapy; Humans; Male; Middle Aged; Myocardial Contraction; peak Vo2; QRS duration; Quality of Life; Stroke Volume - physiology; Treatment Outcome; NYHA; heart failure; EF; FDA; DSMB; CI; MLWHFQ; peak Vo2; CPX; ICD; CCM; QoL; OMT; exercise tolerance; QRS duration; quality of life; pVo2; 6MHW; peak Vo

This study sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients w...