Architecture of the two metal-binding sites in prolactin

• Published in: Biophysical journal Vol. 121; no. 7; pp. 1312 - 1321
• Main Authors: Vang, Janus, Pustovalova, Yulia, Korzhnev, Dmitry M., Gorbatyuk, Oksana, Keeler, Camille, Hodsdon, Michael E., Hoch, Jeffrey C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.04.2022; The Biophysical Society
• Subjects: Binding Sites; Cytoplasmic Granules - metabolism; Growth Hormone - metabolism; Prolactin - metabolism; Proteins - metabolism

Metal binding by members of the growth hormone (GH) family of hematopoietic cytokines has been a subject of considerable interest. However, beyond appreciation of its role in reversible packing of GH proteins in secretory granules, the molecular mechanisms of metal binding and granule formation rema...