Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria

• Published in: Cell reports (Cambridge) Vol. 41; no. 3; p. 111523
• Main Authors: Yao, Zhichao, Cai, Zhaohui, Ma, Qiongke, Bai, Shuai, Wang, Yichen, Zhang, Ping, Guo, Qiongyu, Gu, Jian, Lemaitre, Bruno, Zhang, Hongyu
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.10.2022
• Subjects: Bactrocera dorsalis; gut microbiota; Imd pathway; immune genes; PGRPs; CP: Immunology; immune genes; PGRPs; CP: Microbiology; Imd pathway; gut microbiota; Bactrocera dorsalis

All metazoan guts are subject to opposing pressures wherein the immune system must eliminate pathogens while tolerating the presence of symbiotic microbiota. The Imd pathway is an essential defense against invading pathogens in insect guts, but tolerance mechanisms are less understood. Here, we find...