Pharmacokinetics/pharmacodynamics of epinephrine after single and repeat administration of neffy, EpiPen, and manual intramuscular injection

• Published in: Journal of allergy and clinical immunology Vol. 152; no. 6; pp. 1587 - 1596
• Main Authors: Casale, Thomas B., Ellis, Anne K., Nowak-Wegrzyn, Anna, Kaliner, Michael, Lowenthal, Richard, Tanimoto, Sarina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2023
• Subjects: Anaphylaxis; drug allergy; epinephrine; intranasal; intranasal epinephrine; SBP; Cmax; EpiPen; drug allergy; IM; IN; Epinephrine IM; epinephrine; HR; EAI; BP; L/R; AUC; intranasal epinephrine; Anaphylaxis; DBP; TEmax; PD; R/R; Tmax; intranasal; PK; Emax

Epinephrine is the first-line treatment for severe allergic reactions, and rapid treatment is associated with lower rates of hospitalization and death. Current treatment options (epinephrine auto-injectors and manual intramuscular injection) are considered cumbersome, and most patients/caregivers fa...