The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus

• Published in: Arquivos brasileiros de endocrinologia e metabologia Vol. 56; no. 4; pp. 215 - 225
• Main Authors: Brondani, Letícia de Almeida, Assmann, Taís Silveira, Duarte, Guilherme Coutinho Kullmann, Gross, Jorge Luiz, Canani, Luís Henrique, Crispim, Daisy
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.06.2012
• Subjects: Diabetes Mellitus, Type 2 - genetics; ENDOCRINOLOGY & METABOLISM; Genetic Predisposition to Disease; Humans; Ion Channels - genetics; Ion Channels - physiology; Mitochondrial Proteins - genetics; Mitochondrial Proteins - physiology; Obesity - genetics; Polymorphism, Genetic; Uncoupling Protein 1; DNA polymorphisms; brown adipose tissue; tecido adiposo marrom; UCP1; type 2 diabetes mellitus; polimorfismos de DNA; obesity; obesidade; diabetes melito tipo 2

It is well established that genetic factors play an important role in the development of both type 2 diabetes mellitus (DM2) and obesity, and that genetically susceptible subjects can develop these metabolic diseases after being exposed to environmental risk factors. Therefore, great efforts have be...