Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis

• Published in: European journal of internal medicine Vol. 132; pp. 118 - 126
• Main Authors: Bosco, Giosiana, Di Giacomo Barbagallo, Francesco, Di Marco, Maurizio, Scilletta, Sabrina, Miano, Nicoletta, Capuccio, Stefania, Musmeci, Marco, Di Mauro, Stefania, Filippello, Agnese, Scamporrino, Alessandra, Di Pino, Antonino, Masana, Luis, Purrello, Francesco, Piro, Salvatore, Scicali, Roberto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2025
• Subjects: Adult; Atherosclerosis - blood; Atherosclerosis - complications; Atherosclerosis - immunology; Cardiovascular Risk; Cholesterol, LDL - blood; Cross-Sectional Studies; Familial hypercholesterolemia; Female; Humans; Hyperlipoproteinemia Type II - blood; Hyperlipoproteinemia Type II - complications; Hyperlipoproteinemia Type II - immunology; Hyperlipoproteinemia Type II - metabolism; Immunity, Innate; Inflammation; Innate Immunity; Leukocyte Count; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Subclinical atherosclerosis; Inflammation; Subclinical atherosclerosis; Familial hypercholesterolemia; Cardiovascular Risk; Innate Immunity

•The SA group had higher LDL-C at diagnosis and LCB than the NSA group.•The SA group had higher WBCC, NC and MC than the NSA group.•LCB, WBCC, NC and MC were associated with subclinical atherosclerosis.•LCB was associated with WBCC, NC and MC.•LCB could modulate the innate immunity profile. Familial...