Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys

• Published in: Journal of autoimmunity Vol. 105; p. 102309
• Main Authors: Taylor, Scott, Pieri, Kyriaki, Nanni, Paolo, Tica, Jure, Barratt, Jonathan, Didangelos, Athanasios
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019
• Subjects: B-Cells; Biomarker; IgA nephropathy (IgAN); PEBP4; Proteomics; Urine; Urine; Biomarker; B-Cells; PEBP4; IgA nephropathy (IgAN); Proteomics

IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a major cause of chronic kidney disease and failure. IgAN is driven by an autoimmune reaction against galactose-deficient IgA1 that results in the generation of autoantibodies and large IgG-IgA immune complexes. Immune comple...