Markov state models of biomolecular conformational dynamics

• Published in: Current opinion in structural biology Vol. 25; pp. 135 - 144
• Main Authors: Chodera, John D, Noé, Frank
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2014
• Subjects: Biochemistry - methods; Markov Chains; Models, Molecular; Molecular Conformation; Proteins - chemistry; Proteins - metabolism

•Markov state models (MSMs) are now widely used to study the long-time statistical dynamics of biomolecules.•Recent theoretical advances emphasize MSMs can closely approximate the true statistical dynamics.•MSM construction has been greatly simplified by new software packages.•Numerous applications...