Evaluation of canthinone alkaloids as cerebral protective agents

• Published in: Bioorganic & Medicinal Chemistry Letters Vol. 26; no. 20; pp. 4992 - 4995
• Main Authors: Sasaki, Tatsunori, Li, Wei, Ohmoto, Taichi, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.10.2016; Elsevier BV
• Subjects: Alkaloid; Animals; Brain; Brain - drug effects; Brain Ischemia; Brain Ischemia - prevention & control; Canthinone; Cerebral protective effect; Dementia; Drug Evaluation, Preclinical; Gerbillinae; Indole Alkaloids; Indole Alkaloids - chemistry; Indole Alkaloids - pharmacology; Neuroprotective Agents; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Picrasidine O; Structure-Activity Relationship; Alkaloid; Canthinone; Cerebral protective effect; Picrasidine O; Dementia

[Display omitted] •Five canthinone alkaloids were shown to be cerebral protective agents.•N-3, C-4, and C-9 substitutions affect the cerebral protective effect.•Picrasidine O suppresses neuronal hyperexcitability caused by glutamic acid.•Picrasidine O shows improvement effects on brain tissue damage...