Methamphetamine induced neurotoxic diseases, molecular mechanism, and current treatment strategies

• Published in: Biomedicine & pharmacotherapy Vol. 154; p. 113591
• Main Authors: Shrestha, Prabhat, Katila, Nikita, Lee, Sooyeun, Seo, Ji Hae, Jeong, Jee-Heon, Yook, Simmyung
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.10.2022; Elsevier
• Subjects: Excitotoxicity; Methamphetamine; Neurotoxic disease; Neurotoxicity; Oxidative stress; Targeted therapy; ATF2; Oxidative stress; AMPA; BBB; ROCK2; Targeted therapy; KLH; PARP; Neurotoxic disease; MDMA; Neurotoxicity; VMAT-2; MA; MAPs; PDI; CMA; NMDA; ASYN; UPS; SUMO-1; AD; IL; Methamphetamine; ADAM10; PKC; ER; GSK3β; SERT; GDNF; PD; TNF-α; DAQ; DAT; Excitotoxicity; ROS; MAPT; 5-HT; NET; DA; mGluRs

Methamphetamine (MA) is a extremely addictive psychostimulant drug with a significant abuse potential. Long-term MA exposure can induce neurotoxic effects through oxidative stress, mitochondrial functional impairment, endoplasmic reticulum stress, the activation of astrocytes and microglial cells, a...