Difference of the hemodynamic changes induced by tracheal intubation using remifentanil between smokers and nonsmokers

• Published in: Korean journal of anesthesiology Vol. 58; no. 6; pp. 508 - 513
• Main Authors: Sung, Sang Hoon, Yu, Soo Bong, Kim, Doo Sik, Kim, Kyung Han, Jang, Tae Ho, Kim, Se Hwan, Ryu, Sie Jeong
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Anesthesiologists 01.06.2010; Korean Society of Anesthesiologists; 대한마취통증의학회
• Subjects: Clinical; hemodynamic change; intubation; nonsmoker; remifentanil; smoker; 마취과학; Hemodynamic change; Intubation; Nonsmoker; Smoker; Remifentanil
• DOI: 10.4097/kjae.2010.58.6.508
• ISSN: 2005-6419

It was well-known that smoking affects the cardiovascular system, and remifentanil can suppress the sympathetic stimulations induced by tracheal intubation. The purpose of this study was to investigate whether there was any difference in the hemodynamic changes induced by tracheal intubation with using remifentanil between smokers and nonsmokers. EIGHTY PATIENTS WERE ENROLLED: male smokers (MS), male nonsmokers (MN), female smokers (FS) and female nonsmokers (FN). Anesthesia was induced with diluted remifentanil (20 microg/ml) at a rate of 10 microg/kg/hr using an infusion pump, and 2 min later, midazolam 0.05 mg/kg and propofol 0.8 mg/kg were injected for achieving unconsciousness. Rocuronium 1 mg/kg was used for muscle relaxation, and tracheal intubation was performed 2 min after rocuronium injection. After tracheal intubation, the remifentanil was decreased to 2 microg/kg/hr. The mean arterial pressure (MAP) and heart rate (HR) were checked before induction, on unconsciousness, just before intubation, just after intubation and 1, 2 and 3 minutes after intubation, and these values were compared between the groups. In men, the MAP and HR just after intubation and at 1, 2 and 3 minutes after intubation in Group MS were significantly higher than those of Group MN (P < 0.05). For the women, the HR in both groups (the FS and FN groups) were increased just after intubation and 1, 2 and 3 minutes after intubation compared with that at the baseline, respectively, but there was no difference between the two groups. There was a difference of the hemodynamic changes induced by tracheal intubation with using remifentanil between the male smokers and nonsmokers, but not in women.