TGFβ Signaling in Photoaging and UV-Induced Skin Cancer

• Published in: Journal of investigative dermatology Vol. 141; no. 4; pp. 1104 - 1110
• Main Authors: Ke, Yao, Wang, Xiao-Jing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2021
• Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Genomic Instability - radiation effects; Humans; Immune Checkpoint Inhibitors; Keratinocytes - drug effects; Keratinocytes - pathology; Keratinocytes - radiation effects; Mice; Mutation - radiation effects; Signal Transduction - drug effects; Signal Transduction - genetics; Signal Transduction - radiation effects; Skin - drug effects; Skin - pathology; Skin - radiation effects; Skin Aging - drug effects; Skin Aging - genetics; Skin Aging - radiation effects; Skin Neoplasms - drug therapy; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Transforming Growth Factor beta - antagonists & inhibitors; Transforming Growth Factor beta - metabolism; Tumor Escape - genetics; Tumor Escape - radiation effects; Tumor Microenvironment - drug effects; Tumor Microenvironment - genetics; Tumor Microenvironment - radiation effects; Ultraviolet Rays - adverse effects; Xenograft Model Antitumor Assays; BCC; FN; CAF; AK; EMT; TME; ECM; CTGF; SC; MMP; CSC; SCC; PI3K; SBE; KC; SK; pSMAD; wt; cSCC; HF

UVR is a major etiology for premature skin aging that leads to photoaging and UV-induced skin cancers. In the skin, TGFβ signaling is a growth inhibitor for keratinocytes and a profibrotic factor in the dermis. It exerts context-dependent effects on tumor progression. Chronic UV exposure likely caus...