Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

• Published in: Atherosclerosis Vol. 327; pp. 49 - 58
• Main Authors: Gatsiou, Aikaterini, Georgiopoulos, Georgios, Vlachogiannis, Nikolaos I., Pfisterer, Larissa, Fischer, Ariane, Sachse, Marco, Laina, Ageliki, Bonini, Francesca, Delialis, Dimitrios, Tual-Chalot, Simon, Zormpas, Eleftherios, Achangwa, Rawlings, Jiang, Longchang, Kontogiannis, Christos, Patras, Raphael, Hermeking, Heiko, Zeiher, Andreas M., Stamatelopoulos, Kimon, Dimmeler, Stefanie, Stellos, Konstantinos
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.06.2021
• Subjects: Aging; Atherosclerosis; Cardiovascular disease; Gene expression; Humans; Jagged-1 Protein; Leukocytes, Mononuclear; microRNA; MicroRNAs; miR-34; Sirtuin 1; Vascular ageing; miR-34; Sirtuin 1; Atherosclerosis; microRNA; Cardiovascular disease; Vascular ageing; Gene expression

Preclinical data suggest that the ageing-induced miR-34a regulates vascular senescence. Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease. Expression levels of miR-34a/b/c were quantified by TaqMan assay in peripheral blo...