Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop

• Published in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Vol. 144; no. 3; pp. 284 - 305
• Main Authors: Wong, Anderson O.L., Zhou, Hong, Jiang, Yonghua, Ko, Wendy K.W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2006
• Subjects: Animals; Autocrine/paracrine interactions; Feedback control; Feedback, Physiological; Fish; Fishes - metabolism; Gene expression; Gene Expression Regulation; Gonadotrophs; Gonadotropins - metabolism; Growth hormone; Growth Hormone - biosynthesis; Growth Hormone - metabolism; Luteinizing hormone; Luteinizing Hormone - metabolism; Mammals - metabolism; Pisces; Pituitary; Pituitary Gland - metabolism; Signal transduction; Somatotrophs; Gonadotrophs; Signal transduction; Pituitary; Luteinizing hormone; Autocrine/paracrine interactions; Fish; Feedback control; Somatotrophs; Growth hormone; Gene expression

Growth hormone (GH) is known to play a key role in the regulation of body growth and metabolism. Similar to mammals, GH secretion in fish is under the control of hypothalamic factors. Besides, signals generated within the pituitary and/or from peripheral tissues/organs can also exert a feedback cont...