Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs

• Published in: International journal of pharmaceutics: X Vol. 4; p. 100119
• Main Authors: Meng, Yuanyuan, Tan, Fangyun, Yao, Jiaxin, Cui, Yanan, Feng, Yumiao, Li, Zhiping, Wang, Yuli, Yang, Yang, Gong, Wei, Yang, Meiyan, Kong, Xiaolong, Gao, Chunsheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2022; Elsevier
• Subjects: Beagle dogs; Cocrystals; Dissolution; Permeation; Pharmacokinetics; Research Paper; Rivaroxaban; Solubility; Rivaroxaban; Beagle dogs; Solubility; Permeation; Pharmacokinetics; Cocrystals; Dissolution

Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to improve the solubility and bioavailability of RIV. Five cocrystals—p-hydroxybenzoic acid (HBA), 2,4-dihydro...