Transdermal delivery of selegiline from alginate–Pluronic composite thermogels

• Published in: International journal of pharmaceutics Vol. 415; no. 1; pp. 119 - 128
• Main Authors: Chen, Chih-Chieh, Fang, Chia-Lang, Al-Suwayeh, Saleh A., Leu, Yann-Lii, Fang, Jia-You
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30.08.2011; Elsevier
• Subjects: Administration, Cutaneous; Alginate; Alginates - chemistry; Animals; Biological and medical sciences; Chromatography, High Pressure Liquid; composite polymers; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug Compounding; Female; Freeze Drying; gelatinization temperature; gels; General pharmacology; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; hydrocolloids; Hydrogels; In Vitro Techniques; Medical sciences; Mice; Mice, Nude; Microscopy, Electron, Scanning; Monoamine Oxidase Inhibitors - administration & dosage; Monoamine Oxidase Inhibitors - chemistry; Monoamine Oxidase Inhibitors - pharmacokinetics; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phase Transition; Pluronic F127; Poloxamer - chemistry; porosity; scanning electron microscopy; Selegiline; Selegiline - administration & dosage; Selegiline - chemistry; Selegiline - pharmacokinetics; Skin - metabolism; Skin Absorption; Skin Temperature; Surface Properties; Swine; Thermogel; Transdermal delivery; Transition Temperature; Selegiline; Transdermal delivery; Pluronic F127; Alginate; Thermogel; Monoamine oxidase B inhibitor; Vehicle(excipient); Uronide polymer; Laxative; Composite material; Percutaneous route; Cyclic ether copolymer; Propylene oxide copolymer; Pharmaceutical technology; Enzyme; Enzyme inhibitor; Alginates; Ethylene oxide copolymer; Antiparkinson agent; Amine oxidase (flavin-containing); Polyelectrolyte; Triblock copolymer; Poloxamer; Oside polymer; Oxidoreductases

Representative visual inspection of the aqueous copolymer system at 15 °C (A), 20 °C (B), 25 °C (C), 30 °C (D), and 35 °C (E) (left to right: PF127 (20%), alginate and PF127 blending (A + P, 20% + 0.63%), and the alginate–Pluronic F127 composite copolymer (AP, 15%)). The present work was carried out...