Transdermal delivery of selegiline from alginate–Pluronic composite thermogels - Chen, Chih-Chieh; Fang, Chia-Lang; Al-Suwayeh, Saleh A.; Leu, Yann-Lii; Fang, Jia-You (International journal of pharmaceutics, 2011)
Keywords: Administration, Cutaneous; Alginate; Alginates - chemistry; Animals; Biological and medical sciences; Chromatography, High Pressure Liquid; composite polymers; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug Compounding; Female; Freeze Drying; gelatinization temperature; gels; General pharmacology; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; hydrocolloids; Hydrogels; In Vitro Techniques; Medical sciences; Mice; Mice, Nude; Microscopy, Electron, Scanning; Monoamine Oxidase Inhibitors - administration & dosage; Monoamine Oxidase Inhibitors - chemistry; Monoamine Oxidase Inhibitors - pharmacokinetics; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phase Transition; Pluronic F127; Poloxamer - chemistry; porosity; scanning electron microscopy; Selegiline; Selegiline - administration & dosage; Selegiline - chemistry; Selegiline - pharmacokinetics; Skin - metabolism; Skin Absorption; Skin Temperature; Surface Properties; Swine; Thermogel; Transdermal delivery; Transition Temperature; Selegiline; Transdermal delivery; Pluronic F127; Alginate; Thermogel; Monoamine oxidase B inhibitor; Vehicle(excipient); Uronide polymer; Laxative; Composite material; Percutaneous route; Cyclic ether copolymer; Propylene oxide copolymer; Pharmaceutical technology; Enzyme; Enzyme inhibitor; Alginates; Ethylene oxide copolymer; Antiparkinson agent; Amine oxidase (flavin-containing); Polyelectrolyte; Triblock copolymer; Poloxamer; Oside polymer; Oxidoreductases