Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease

• Published in: Biomedicine & pharmacotherapy Vol. 167; p. 115469
• Main Authors: Ballester-Servera, Carme, Alonso, Judith, Cañes, Laia, Vázquez-Sufuentes, Paula, Puertas-Umbert, Lídia, Fernández-Celis, Amaya, Taurón, Manel, Rodríguez-Sinovas, Antonio, López-Andrés, Natalia, Rodríguez, Cristina, Martínez-González, José
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.11.2023; Elsevier
• Subjects: Atherosclerosis; Cardiovascular calcification; Extracellular matrix remodeling; Lysyl oxidase; DHE; OPG; NIRF; OPN; ORO; TNAP; α-SMA; CAVD; LOXL; Atherosclerosis; LDLR; WT; OM; Cardiovascular calcification; VSMCs; BAPN; Extracellular matrix remodeling; DKK-1; VICs; Lysyl oxidase; ECM; RUNX2; CVC; LOX; AAV; HC; HF

Extracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX might impact on mineral deposition in calcific aor...