The neural basis of heat seeking in a human-infective parasitic worm

Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae that locate hosts using thermal cues. Here, we identify the thermosensory neurons of the human threadworm Strongyloides stercoralis and show th...

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Published inCurrent biology Vol. 32; no. 10; pp. 2206 - 2221.e6
Main Authors Bryant, Astra S., Ruiz, Felicitas, Lee, Joon Ha, Hallem, Elissa A.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 23.05.2022
Subjects
AFD neuron
Animals
C. elegans
Caenorhabditis elegans
calcium imaging
heat seeking
Helminths
host-seeking
Hot Temperature
Humans
Larva - physiology
Nematoda - physiology
parasitic helminth
parasitic nematode
Strongyloides stercoralis
Strongyloides stercoralis - physiology
Thermoreceptors
thermosensation
thermotaxis
C. elegans
parasitic nematode
heat seeking
host-seeking
Strongyloides stercoralis
AFD neuron
parasitic helminth
thermosensation
thermotaxis
calcium imaging
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Abstract Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae that locate hosts using thermal cues. Here, we identify the thermosensory neurons of the human threadworm Strongyloides stercoralis and show that they display unique functional adaptations that enable the precise encoding of temperatures up to human body temperature. We demonstrate that experience-dependent thermal plasticity regulates the dynamic range of these neurons while preserving their ability to encode host-relevant temperatures. We describe a novel behavior in which infective larvae spontaneously reverse attraction to heat sources at sub-body temperatures and show that this behavior is mediated by rapid adaptation of the thermosensory neurons. Finally, we identify thermoreceptors that confer parasite-specific sensitivity to body heat. Our results pinpoint the parasite-specific neural adaptations that enable parasitic nematodes to target humans and provide the foundation for drug development to prevent human infection. •S. stercoralis senses temperature via the conserved AFD sensory neuron pair•Heat seeking by S. stercoralis infective larvae requires Ss-AFD neurons•Ss-AFD neurons display unique temperature-encoding strategies•Three receptor-type guanylate cyclases in Ss-AFD sense body heat Bryant et al. report that the skin-penetrating, human-parasitic nematode Strongyloides stercoralis relies on a conserved thermosensory neuron pair to drive attraction to human body heat. The authors demonstrate that parasite-specific sensory encoding strategies drive temperature-driven host seeking by human-infective parasitic worms.
AbstractList Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae that locate hosts using thermal cues. Here, we identify the thermosensory neurons of the human threadworm Strongyloides stercoralis and show that they display unique functional adaptations that enable the precise encoding of temperatures up to human body temperature. We demonstrate that experience-dependent thermal plasticity regulates the dynamic range of these neurons while preserving their ability to encode host-relevant temperatures. We describe a novel behavior in which infective larvae spontaneously reverse attraction to heat sources at sub-body temperatures and show that this behavior is mediated by rapid adaptation of the thermosensory neurons. Finally, we identify thermoreceptors that confer parasite-specific sensitivity to body heat. Our results pinpoint the parasite-specific neural adaptations that enable parasitic nematodes to target humans and provide the foundation for drug development to prevent human infection.
Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae that locate hosts using thermal cues. Here, we identify the thermosensory neurons of the human threadworm Strongyloides stercoralis and show that they display unique functional adaptations that enable the precise encoding of temperatures up to human body temperature. We demonstrate that experience-dependent thermal plasticity regulates the dynamic range of these neurons while preserving their ability to encode host-relevant temperatures. We describe a novel behavior in which infective larvae spontaneously reverse attraction to heat sources at sub-body temperatures and show that this behavior is mediated by rapid adaptation of the thermosensory neurons. Finally, we identify thermoreceptors that confer parasite-specific sensitivity to body heat. Our results pinpoint the parasite-specific neural adaptations that enable parasitic nematodes to target humans and provide the foundation for drug development to prevent human infection. Bryant et al . report that the skin-penetrating, human-parasitic nematode Strongyloides stercoralis relies on a conserved thermosensory neuron pair to drive attraction to human body heat. The authors demonstrate that parasite-specific sensory encoding strategies drive temperature-driven host seeking by human-infective parasitic worms.
Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae that locate hosts using thermal cues. Here, we identify the thermosensory neurons of the human threadworm Strongyloides stercoralis and show that they display unique functional adaptations that enable the precise encoding of temperatures up to human body temperature. We demonstrate that experience-dependent thermal plasticity regulates the dynamic range of these neurons while preserving their ability to encode host-relevant temperatures. We describe a novel behavior in which infective larvae spontaneously reverse attraction to heat sources at sub-body temperatures and show that this behavior is mediated by rapid adaptation of the thermosensory neurons. Finally, we identify thermoreceptors that confer parasite-specific sensitivity to body heat. Our results pinpoint the parasite-specific neural adaptations that enable parasitic nematodes to target humans and provide the foundation for drug development to prevent human infection. •S. stercoralis senses temperature via the conserved AFD sensory neuron pair•Heat seeking by S. stercoralis infective larvae requires Ss-AFD neurons•Ss-AFD neurons display unique temperature-encoding strategies•Three receptor-type guanylate cyclases in Ss-AFD sense body heat Bryant et al. report that the skin-penetrating, human-parasitic nematode Strongyloides stercoralis relies on a conserved thermosensory neuron pair to drive attraction to human body heat. The authors demonstrate that parasite-specific sensory encoding strategies drive temperature-driven host seeking by human-infective parasitic worms.
Author Lee, Joon Ha
Ruiz, Felicitas
Hallem, Elissa A.
Bryant, Astra S.
AuthorAffiliation 2 Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095
3 Lead contact
1 Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095
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  givenname: Felicitas
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  givenname: Joon Ha
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  email: ehallem@ucla.edu
  organization: Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
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Cites_doi 10.3389/fnmol.2013.00026
10.1093/genetics/139.2.993
10.1016/j.molbiopara.2016.11.005
10.1038/ng.3495
10.1186/1471-2202-7-30
10.3390/ijerph13050517
10.1007/s00424-017-2089-5
10.1534/genetics.105.050013
10.1073/pnas.1400615111
10.1038/nn.2157
10.1017/S0031182016000834
10.1002/cne.903570208
10.1080/01677063.2020.1734001
10.1186/1471-2334-13-78
10.1001/jama.2020.13170
10.1001/jama.299.16.1937
10.1016/j.neuron.2016.03.002
10.1016/j.exppara.2007.08.018
10.1016/j.cub.2004.06.060
10.1101/gad.1953710
10.1073/pnas.1315205111
10.1371/journal.ppat.1006675
10.1093/g3journal/jkab146
10.1016/S0140-6736(06)68653-4
10.1016/j.cell.2019.07.034
10.1073/pnas.72.10.4061
10.4269/ajtmh.19-0915
10.1016/j.vetpar.2016.09.006
10.1534/genetics.106.055749
10.1016/j.neulet.2018.10.023
10.1073/pnas.96.18.10477
10.1073/pnas.0409009101
10.1085/jgp.201310959
10.1007/s11894-006-0052-2
10.1093/oxfordjournals.molbev.a003851
10.1038/nn1796
10.1093/cid/cix1069
10.1002/cpbi.96
10.1016/S0896-6273(00)80201-9
10.1186/1471-2148-6-26
10.1523/JNEUROSCI.1137-06.2006
10.1038/ncomms3198
10.1895/wormbook.1.168.1
10.3390/pathogens9060468
10.1016/j.ijpddr.2018.10.008
10.1534/g3.117.040824
10.1038/nmeth.1565
10.1093/molbev/msu300
10.1038/nmeth.4285
10.1534/genetics.116.195511
10.1017/S0031182016000391
10.1534/genetics.119.302392
10.1371/journal.pntd.0001582
10.1038/nmeth.2019
10.1016/j.neuron.2014.10.046
10.1186/gb-2006-7-8-r75
10.1016/j.cub.2011.01.053
10.1093/molbev/msz240
10.1016/j.cub.2016.07.044
10.7554/eLife.47155
10.1073/pnas.0400417101
10.3758/BRM.41.4.1149
10.1016/S0304-4017(99)00037-0
10.1093/molbev/mss140
10.4269/ajtmh.18-0895
10.1016/j.cub.2018.05.063
10.1038/376344a0
10.1534/genetics.111.127100
10.1016/S0896-6273(00)80202-0
10.4269/ajtmh.17-0396
10.1016/S0020-7519(00)00087-4
10.1371/journal.pntd.0001854
10.1073/pnas.1909710117
10.4269/ajtmh.12-0484
10.1016/j.neuron.2017.12.027
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Keywords C. elegans
parasitic nematode
heat seeking
host-seeking
Strongyloides stercoralis
AFD neuron
parasitic helminth
thermosensation
thermotaxis
calcium imaging
Language English
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Present address: Yale Interdepartmental Neuroscience Program, Yale University, 260 Whitney Ave, New Haven, CT 06511
Present address: Molecular & Cellular Biology in Seattle Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98115
A.S.B. and E.A.H. conceived the study and wrote the manuscript. A.S.B., F.R., and J.L. performed all experiments and analyzed the data. All authors read and approved the final manuscript.
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References Bryant, Ruiz, Gang, Castelletto, Lopez, Hallem (bib22) 2018; 28
Takeishi, Yu, Hapiak, Bell, O’Leary, Sengupta (bib37) 2016; 90
De Wilton, Nabarro, Godbole, Chiodini, Boyd, Woods (bib15) 2021; 40
Wasserman, Beverly, Bell, Sengupta (bib35) 2011; 21
Kimura, Miyawaki, Matsumoto, Mori (bib46) 2004; 14
Hong, Riebesell, Bumbarger, Cook, Carstensen, Sarpolaki, Cochella, Castrejon, Moreno, Sieriebriennikov (bib57) 2019; 8
Wickham (bib65) 2009
Keiser, Utzinger (bib10) 2008; 299
Takeishi, Takagaki, Kuhara (bib31) 2020; 34
Redemann, Schloissnig, Ernst, Pozniakowsky, Ayloo, Hyman, Bringmann (bib82) 2011; 8
Yu (bib77) 2020; 69
Gang, Castelletto, Yang, Ruiz, Brown, Bryant, Grant, Hallem (bib24) 2020; 117
Han, Boas, Schroeder (bib56) 2015; 9
Lok, Shao, Massey, Li (bib80) 2017; 144
Stauffer, Alpern, Walker (bib16) 2020; 324
Garrity, Goodman, Samuel, Sengupta (bib28) 2010; 24
Luo, Cook, Venkatachalam, Martinez-Velazquez, Zhang, Calvo, Hawk, MacInnis, Frank, Ng (bib34) 2014; 111
Schild, Glauser (bib29) 2013; 4
Pokala, Liu, Gordus, Bargmann (bib43) 2014; 111
Nguyen, Schmidt, von Haeseler, Minh (bib71) 2015; 32
Ashton, Li, Schad (bib36) 1999; 84
Bryant, Hallem (bib81) 2021; 11
Gong, Liu, Ronan, He, Cai, Fatima, Zhang, Lee, Li, Kim (bib53) 2019; 178
Schulenburg, Félix (bib59) 2017; 206
Schafer, Skopic (bib7) 2006; 8
Biron, Shibuya, Gabel, Wasserman, Clark, Brown, SenGupta, Samuel (bib62) 2006; 9
Beknazarova, Whiley, Ross (bib1) 2016; 13
Bryant, Hallem (bib23) 2018; 8
Kalyaanamoorthy, Minh, Wong, von Haeseler, Jermiin (bib72) 2017; 14
Buonfrate, Requena-Mendez, Angheben, Muñoz, Gobbi, Van Den Ende, Bisoffi (bib8) 2013; 13
Goodman, Sengupta (bib30) 2018; 470
Singer, Xu, Herrera, Villar, Faust, Hotez, Aiken, Mejia (bib5) 2020; 102
Yu, Bell, Glauser, Van Hooser, Goodman, Sengupta (bib61) 2014; 84
Nutman (bib6) 2017; 144
Roberts, Janovy (bib60) 2005
Goodman (bib83) 2014
Glauser, Chen, Agin, Macinnis, Hellman, Garrity, Tan, Goodman (bib27) 2011; 188
Bryant, Hallem (bib19) 2018; 687
Nguyen, Liou, Hall, Leroux (bib52) 2014; 127
Ramot, MacInnis, Goodman (bib38) 2008; 11
Buonfrate, Bisanzio, Giorli, Odermatt, Fürst, Greenaway, French, Reithinger, Gobbi, Montresor, Bisoffi (bib13) 2020; 9
Lok (bib68) 2007
Woldemariam, Nagpal, Hill, Li, Schneider, Shankar, Futey, Varshney, Ali, Mitchell (bib55) 2019; 213
Mori, Ohshima (bib32) 1995; 376
Mitreva, Wendl, Martin, Wylie, Yin, Larson, Parkinson, Waterston, McCarter (bib79) 2006; 7
Stiernagle (bib66) 2006
Ortiz, Etchberger, Posy, Frøkjaer-Jensen, Lockery, Honig, Hobert (bib42) 2006; 173
Clark, Biron, Sengupta, Samuel (bib45) 2006; 26
Komatsu, Mori, Rhee, Akaike, Ohshima (bib49) 1996; 17
Diawara, Schwenkenbecher, Kaplan, Prichard (bib9) 2013; 88
Hawk, Calvo, Liu, Almoril-Porras, Aljobeh, Torruella-Suárez, Ren, Cook, Greenwood, Luo (bib47) 2018; 97
Gray, Hill, Bargmann (bib51) 2005; 102
Fitzpatrick, O’Halloran, Burnell (bib41) 2006; 6
El Mouridi, Lecroisey, Tardy, Mercier, Leclercq-Blondel, Zariohi, Boulin (bib78) 2017; 7
Ashton, Bhopale, Fine, Schad (bib20) 1995; 357
Junio, Li, Massey, Nolan, Todd Lamitina, Sundaram, Lok (bib69) 2008; 118
Chung, Clark, Gabel, Mazur, Samuel (bib33) 2006; 7
Hawdon, Schad (bib67) 1991; 58
Lopez, Boston, Ashton, Schad (bib21) 2000; 30
Nagai, Yamada, Tominaga, Ichikawa, Miyawaki (bib44) 2004; 101
Soubrier, Steel, Lee, Der Sarkissian, Guindon (bib74) 2012; 29
Repetto, Ruybal, Batalla, López, Fridman, Sierra, Radisic, Bravo, Risso, González Cappa, Alba Soto (bib12) 2018; 66
Lustigman, Prichard, Gazzinelli, Grant, Boatin, McCarthy, Basáñez (bib3) 2012; 6
Learmount, Stephens, Boughtflower, Barrecheguren, Rickell (bib11) 2016; 229
Wittenburg, Baumeister (bib26) 1999; 96
Wang, Lam, Xu, Dai, Zhou, Feng, Guo, Dunn, Jones, Bradley (bib76) 2020; 37
Howe, Bolt, Shafie, Kersey, Berriman (bib70) 2017; 215
Schindelin, Arganda-Carreras, Frise, Kaynig, Longair, Pietzsch, Preibisch, Rueden, Saalfeld, Schmid (bib63) 2012; 9
Wang, O’Halloran, Goodman (bib40) 2013; 142
Gang, Castelletto, Bryant, Yang, Mancuso, Lopez, Pellegrini, Hallem (bib48) 2017; 13
Tamarozzi, Martello, Giorli, Fittipaldo, Staffolani, Montresor, Bisoffi, Buonfrate (bib14) 2019; 100
Yang (bib75) 1995; 139
Stoltzfus, Minot, Berriman, Nolan, Lok (bib18) 2012; 6
Bethony, Brooker, Albonico, Geiger, Loukas, Diemert, Hotez (bib2) 2006; 367
Inada, Ito, Satterlee, Sengupta, Matsumoto, Mori (bib39) 2006; 172
Schafer (bib58) 2016; 26
Faul, Erdfelder, Buchner, Lang (bib64) 2009; 41
Hunt, Tsai, Coghlan, Reid, Holroyd, Foth, Tracey, Cotton, Stanley, Beasley (bib17) 2016; 48
Whelan, Goldman (bib73) 2001; 18
Bhargava, Hampden-Smith, Chachlaki, Wood, Vernon, Allerston, Batchelor, Garthwaite (bib54) 2013; 6
McKenna, McAtee, Bryan, Jeun, Ward, Kraus, Bottazzi, Hotez, Flowers, Mejia (bib4) 2017; 97
Coburn, Bargmann (bib50) 1996; 17
Hedgecock, Russell (bib25) 1975; 72
35609543 - Curr Biol. 2022 May 23;32(10):R464-R466
Tamarozzi (10.1016/j.cub.2022.04.010_bib14) 2019; 100
Stoltzfus (10.1016/j.cub.2022.04.010_bib18) 2012; 6
Ortiz (10.1016/j.cub.2022.04.010_bib42) 2006; 173
Lopez (10.1016/j.cub.2022.04.010_bib21) 2000; 30
Wittenburg (10.1016/j.cub.2022.04.010_bib26) 1999; 96
Faul (10.1016/j.cub.2022.04.010_bib64) 2009; 41
Glauser (10.1016/j.cub.2022.04.010_bib27) 2011; 188
Lustigman (10.1016/j.cub.2022.04.010_bib3) 2012; 6
Lok (10.1016/j.cub.2022.04.010_bib68) 2007
Junio (10.1016/j.cub.2022.04.010_bib69) 2008; 118
Gang (10.1016/j.cub.2022.04.010_bib24) 2020; 117
Yang (10.1016/j.cub.2022.04.010_bib75) 1995; 139
El Mouridi (10.1016/j.cub.2022.04.010_bib78) 2017; 7
Yu (10.1016/j.cub.2022.04.010_bib77) 2020; 69
Beknazarova (10.1016/j.cub.2022.04.010_bib1) 2016; 13
Wang (10.1016/j.cub.2022.04.010_bib76) 2020; 37
Soubrier (10.1016/j.cub.2022.04.010_bib74) 2012; 29
Bryant (10.1016/j.cub.2022.04.010_bib81) 2021; 11
Bryant (10.1016/j.cub.2022.04.010_bib23) 2018; 8
Takeishi (10.1016/j.cub.2022.04.010_bib37) 2016; 90
Wickham (10.1016/j.cub.2022.04.010_bib65) 2009
Whelan (10.1016/j.cub.2022.04.010_bib73) 2001; 18
Keiser (10.1016/j.cub.2022.04.010_bib10) 2008; 299
Hunt (10.1016/j.cub.2022.04.010_bib17) 2016; 48
Goodman (10.1016/j.cub.2022.04.010_bib83) 2014
Bethony (10.1016/j.cub.2022.04.010_bib2) 2006; 367
Luo (10.1016/j.cub.2022.04.010_bib34) 2014; 111
Ashton (10.1016/j.cub.2022.04.010_bib20) 1995; 357
Garrity (10.1016/j.cub.2022.04.010_bib28) 2010; 24
Nagai (10.1016/j.cub.2022.04.010_bib44) 2004; 101
Singer (10.1016/j.cub.2022.04.010_bib5) 2020; 102
Gang (10.1016/j.cub.2022.04.010_bib48) 2017; 13
Hong (10.1016/j.cub.2022.04.010_bib57) 2019; 8
Inada (10.1016/j.cub.2022.04.010_bib39) 2006; 172
Diawara (10.1016/j.cub.2022.04.010_bib9) 2013; 88
Stauffer (10.1016/j.cub.2022.04.010_bib16) 2020; 324
Schafer (10.1016/j.cub.2022.04.010_bib7) 2006; 8
Clark (10.1016/j.cub.2022.04.010_bib45) 2006; 26
Komatsu (10.1016/j.cub.2022.04.010_bib49) 1996; 17
Bryant (10.1016/j.cub.2022.04.010_bib19) 2018; 687
Fitzpatrick (10.1016/j.cub.2022.04.010_bib41) 2006; 6
Han (10.1016/j.cub.2022.04.010_bib56) 2015; 9
Schulenburg (10.1016/j.cub.2022.04.010_bib59) 2017; 206
Wang (10.1016/j.cub.2022.04.010_bib40) 2013; 142
Chung (10.1016/j.cub.2022.04.010_bib33) 2006; 7
Bryant (10.1016/j.cub.2022.04.010_bib22) 2018; 28
McKenna (10.1016/j.cub.2022.04.010_bib4) 2017; 97
Woldemariam (10.1016/j.cub.2022.04.010_bib55) 2019; 213
Repetto (10.1016/j.cub.2022.04.010_bib12) 2018; 66
Ramot (10.1016/j.cub.2022.04.010_bib38) 2008; 11
Schild (10.1016/j.cub.2022.04.010_bib29) 2013; 4
Nguyen (10.1016/j.cub.2022.04.010_bib71) 2015; 32
Gong (10.1016/j.cub.2022.04.010_bib53) 2019; 178
Hawk (10.1016/j.cub.2022.04.010_bib47) 2018; 97
Kalyaanamoorthy (10.1016/j.cub.2022.04.010_bib72) 2017; 14
Coburn (10.1016/j.cub.2022.04.010_bib50) 1996; 17
Buonfrate (10.1016/j.cub.2022.04.010_bib13) 2020; 9
Lok (10.1016/j.cub.2022.04.010_bib80) 2017; 144
Schindelin (10.1016/j.cub.2022.04.010_bib63) 2012; 9
Pokala (10.1016/j.cub.2022.04.010_bib43) 2014; 111
Hedgecock (10.1016/j.cub.2022.04.010_bib25) 1975; 72
Mitreva (10.1016/j.cub.2022.04.010_bib79) 2006; 7
Redemann (10.1016/j.cub.2022.04.010_bib82) 2011; 8
Gray (10.1016/j.cub.2022.04.010_bib51) 2005; 102
Nguyen (10.1016/j.cub.2022.04.010_bib52) 2014; 127
De Wilton (10.1016/j.cub.2022.04.010_bib15) 2021; 40
Ashton (10.1016/j.cub.2022.04.010_bib36) 1999; 84
Roberts (10.1016/j.cub.2022.04.010_bib60) 2005
Stiernagle (10.1016/j.cub.2022.04.010_bib66) 2006
Howe (10.1016/j.cub.2022.04.010_bib70) 2017; 215
Mori (10.1016/j.cub.2022.04.010_bib32) 1995; 376
Bhargava (10.1016/j.cub.2022.04.010_bib54) 2013; 6
Goodman (10.1016/j.cub.2022.04.010_bib30) 2018; 470
Biron (10.1016/j.cub.2022.04.010_bib62) 2006; 9
Wasserman (10.1016/j.cub.2022.04.010_bib35) 2011; 21
Buonfrate (10.1016/j.cub.2022.04.010_bib8) 2013; 13
Yu (10.1016/j.cub.2022.04.010_bib61) 2014; 84
Nutman (10.1016/j.cub.2022.04.010_bib6) 2017; 144
Schafer (10.1016/j.cub.2022.04.010_bib58) 2016; 26
Takeishi (10.1016/j.cub.2022.04.010_bib31) 2020; 34
Hawdon (10.1016/j.cub.2022.04.010_bib67) 1991; 58
Learmount (10.1016/j.cub.2022.04.010_bib11) 2016; 229
Kimura (10.1016/j.cub.2022.04.010_bib46) 2004; 14
References_xml – start-page: 1
  year: 2006
  end-page: 11
  ident: bib66
  article-title: Maintenance of
  publication-title: WormBook
  contributor:
    fullname: Stiernagle
– volume: 90
  start-page: 235
  year: 2016
  end-page: 244
  ident: bib37
  article-title: Receptor-type guanylyl cyclases confer thermosensory responses in
  publication-title: Neuron
  contributor:
    fullname: Sengupta
– volume: 173
  start-page: 131
  year: 2006
  end-page: 149
  ident: bib42
  article-title: Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases
  publication-title: Genetics
  contributor:
    fullname: Hobert
– volume: 376
  start-page: 344
  year: 1995
  end-page: 348
  ident: bib32
  article-title: Neural regulation of thermotaxis in
  publication-title: Nature
  contributor:
    fullname: Ohshima
– volume: 213
  start-page: 59
  year: 2019
  end-page: 77
  ident: bib55
  article-title: Using a robust and sensitive GFP-based cGMP sensor for real time imaging in intact
  publication-title: Genetics
  contributor:
    fullname: Mitchell
– volume: 11
  start-page: jkab146
  year: 2021
  ident: bib81
  article-title: The Wild Worm Codon Adapter: a web tool for automated codon adaptation of transgenes for expression in non-
  publication-title: G3 (Bethesda)
  contributor:
    fullname: Hallem
– volume: 11
  start-page: 908
  year: 2008
  end-page: 915
  ident: bib38
  article-title: Bidirectional temperature-sensing by a single thermosensory neuron in
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Goodman
– volume: 48
  start-page: 299
  year: 2016
  end-page: 307
  ident: bib17
  article-title: The genomic basis of parasitism in the
  publication-title: Nat. Genet.
  contributor:
    fullname: Beasley
– volume: 142
  start-page: 437
  year: 2013
  end-page: 449
  ident: bib40
  article-title: GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for
  publication-title: J. Gen. Physiol.
  contributor:
    fullname: Goodman
– volume: 6
  start-page: e1582
  year: 2012
  ident: bib3
  article-title: A research agenda for helminth diseases of humans: the problem of helminthiases
  publication-title: PLoS Negl. Trop. Dis.
  contributor:
    fullname: Basáñez
– volume: 6
  start-page: e1854
  year: 2012
  ident: bib18
  article-title: RNAseq analysis of the parasitic nematode
  publication-title: PLoS Negl. Trop. Dis.
  contributor:
    fullname: Lok
– volume: 9
  start-page: 1499
  year: 2006
  end-page: 1505
  ident: bib62
  article-title: A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Samuel
– volume: 30
  start-page: 1115
  year: 2000
  end-page: 1121
  ident: bib21
  article-title: The neurons of class ALD mediate thermotaxis in the parasitic nematode,
  publication-title: Int. J. Parasitol.
  contributor:
    fullname: Schad
– volume: 69
  start-page: e96
  year: 2020
  ident: bib77
  article-title: Using ggtree to visualize data on tree-like structures
  publication-title: Curr. Protoc. Bioinformatics
  contributor:
    fullname: Yu
– volume: 102
  start-page: 3184
  year: 2005
  end-page: 3191
  ident: bib51
  article-title: A circuit for navigation in
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Bargmann
– volume: 229
  start-page: 9
  year: 2016
  end-page: 14
  ident: bib11
  article-title: The development of anthelmintic resistance with best practice control of nematodes on commercial sheep farms in the UK
  publication-title: Vet. Parasitol.
  contributor:
    fullname: Rickell
– volume: 96
  start-page: 10477
  year: 1999
  end-page: 10482
  ident: bib26
  article-title: Thermal avoidance in
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Baumeister
– volume: 18
  start-page: 691
  year: 2001
  end-page: 699
  ident: bib73
  article-title: A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach
  publication-title: Mol. Biol. Evol.
  contributor:
    fullname: Goldman
– volume: 111
  start-page: 2770
  year: 2014
  end-page: 2775
  ident: bib43
  article-title: Inducible and titratable silencing of
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Bargmann
– volume: 8
  start-page: 250
  year: 2011
  end-page: 252
  ident: bib82
  article-title: Codon adaptation-based control of protein expression in
  publication-title: Nat. Methods
  contributor:
    fullname: Bringmann
– volume: 172
  start-page: 2239
  year: 2006
  end-page: 2252
  ident: bib39
  article-title: Identification of guanylyl cyclases that function in thermosensory neurons of
  publication-title: Genetics
  contributor:
    fullname: Mori
– volume: 111
  start-page: 2776
  year: 2014
  end-page: 2781
  ident: bib34
  article-title: Bidirectional thermotaxis in
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Ng
– volume: 97
  start-page: 1623
  year: 2017
  end-page: 1628
  ident: bib4
  article-title: Human intestinal parasite burden and poor sanitation in rural Alabama
  publication-title: Am. J. Trop. Med. Hyg.
  contributor:
    fullname: Mejia
– volume: 118
  start-page: 253
  year: 2008
  end-page: 265
  ident: bib69
  article-title: : cell- and tissue-specific transgene expression and co-transformation with vector constructs incorporating a common multifunctional 3′ UTR
  publication-title: Exp. Parasitol.
  contributor:
    fullname: Lok
– year: 2005
  ident: bib60
  article-title: Gerald D. Schmidt & Larry S. Roberts’ Foundations of Parasitology
  contributor:
    fullname: Janovy
– volume: 7
  start-page: 30
  year: 2006
  ident: bib33
  article-title: The role of the AFD neuron in
  publication-title: BMC Neurosci.
  contributor:
    fullname: Samuel
– volume: 101
  start-page: 10554
  year: 2004
  end-page: 10559
  ident: bib44
  article-title: Expanded dynamic range of fluorescent indicators for Ca
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Miyawaki
– volume: 17
  start-page: 695
  year: 1996
  end-page: 706
  ident: bib50
  article-title: A putative cyclic nucleotide-gated channel is required for sensory development and function in
  publication-title: Neuron
  contributor:
    fullname: Bargmann
– volume: 188
  start-page: 91
  year: 2011
  end-page: 103
  ident: bib27
  article-title: Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in
  publication-title: Genetics
  contributor:
    fullname: Goodman
– volume: 26
  start-page: R955
  year: 2016
  end-page: R959
  ident: bib58
  article-title: Nematode nervous systems
  publication-title: Curr. Biol.
  contributor:
    fullname: Schafer
– volume: 72
  start-page: 4061
  year: 1975
  end-page: 4065
  ident: bib25
  article-title: Normal and mutant thermotaxis in the nematode
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Russell
– volume: 84
  start-page: 919
  year: 2014
  end-page: 926
  ident: bib61
  article-title: CaMKI-Dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron
  publication-title: Neuron
  contributor:
    fullname: Sengupta
– volume: 58
  start-page: 140
  year: 1991
  end-page: 142
  ident: bib67
  article-title: Long-term storage of hookworm infective larvae in buffered saline solution maintains larval responsiveness to host signals
  publication-title: J. Helm Soc. Wash.
  contributor:
    fullname: Schad
– volume: 37
  start-page: 599
  year: 2020
  end-page: 603
  ident: bib76
  article-title: Treeio: an R package for phylogenetic tree input and output with richly annotated and associated data
  publication-title: Mol. Biol. Evol.
  contributor:
    fullname: Bradley
– volume: 9
  start-page: 468
  year: 2020
  ident: bib13
  article-title: The global prevalence of
  publication-title: Pathogens
  contributor:
    fullname: Bisoffi
– volume: 100
  start-page: 1305
  year: 2019
  end-page: 1311
  ident: bib14
  article-title: Morbidity associated with chronic
  publication-title: Am. J. Trop. Med. Hyg.
  contributor:
    fullname: Buonfrate
– volume: 127
  start-page: 5317
  year: 2014
  end-page: 5330
  ident: bib52
  article-title: Ciliopathy proteins establish a bipartite signaling compartment in a
  publication-title: J. Cell Sci.
  contributor:
    fullname: Leroux
– volume: 97
  start-page: 356
  year: 2018
  end-page: 367.e4
  ident: bib47
  article-title: Integration of plasticity mechanisms within a single sensory neuron of
  publication-title: Neuron
  contributor:
    fullname: Luo
– volume: 6
  start-page: 26
  year: 2013
  ident: bib54
  article-title: Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging
  publication-title: Front. Mol. Neurosci.
  contributor:
    fullname: Garthwaite
– volume: 24
  start-page: 2365
  year: 2010
  end-page: 2382
  ident: bib28
  article-title: Running hot and cold: behavioral strategies, neural circuits, and the molecular machinery for thermotaxis in
  publication-title: Genes Dev.
  contributor:
    fullname: Sengupta
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: bib63
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat. Methods
  contributor:
    fullname: Schmid
– volume: 29
  start-page: 3345
  year: 2012
  end-page: 3358
  ident: bib74
  article-title: The influence of rate heterogeneity among sites on the time dependence of molecular rates
  publication-title: Mol. Biol. Evol.
  contributor:
    fullname: Guindon
– start-page: 1
  year: 2014
  end-page: 10
  ident: bib83
  article-title: Thermotaxis navigation behavior
  publication-title: WormBook
  contributor:
    fullname: Goodman
– volume: 41
  start-page: 1149
  year: 2009
  end-page: 1160
  ident: bib64
  article-title: Statistical power analyses using G
  publication-title: Behav. Res. Methods
  contributor:
    fullname: Lang
– volume: 139
  start-page: 993
  year: 1995
  end-page: 1005
  ident: bib75
  article-title: A space-time process model for the evolution of DNA sequences
  publication-title: Genetics
  contributor:
    fullname: Yang
– volume: 66
  start-page: 1558
  year: 2018
  end-page: 1565
  ident: bib12
  article-title: Strongyloidiasis outside endemic areas: long-term parasitological and clinical follow-up after ivermectin treatment
  publication-title: Clin. Infect. Dis.
  contributor:
    fullname: Alba Soto
– volume: 215
  start-page: 2
  year: 2017
  end-page: 10
  ident: bib70
  article-title: WormBase ParaSite − a comprehensive resource for helminth genomics
  publication-title: Mol. Biochem. Parasitol.
  contributor:
    fullname: Berriman
– volume: 8
  start-page: 496
  year: 2018
  end-page: 510
  ident: bib23
  article-title: Terror in the dirt: sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes
  publication-title: Int. J. Parasitol. Drugs Drug Resist.
  contributor:
    fullname: Hallem
– volume: 8
  start-page: e47155
  year: 2019
  ident: bib57
  article-title: Evolution of neuronal anatomy and circuitry in two highly divergent nematode species
  publication-title: Elife
  contributor:
    fullname: Sieriebriennikov
– volume: 299
  start-page: 1937
  year: 2008
  end-page: 1948
  ident: bib10
  article-title: Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
  publication-title: JAMA
  contributor:
    fullname: Utzinger
– volume: 14
  start-page: 1291
  year: 2004
  end-page: 1295
  ident: bib46
  article-title: The
  publication-title: Curr. Biol.
  contributor:
    fullname: Mori
– volume: 144
  start-page: 263
  year: 2017
  end-page: 273
  ident: bib6
  article-title: Human infection with
  publication-title: Parasitology
  contributor:
    fullname: Nutman
– volume: 324
  start-page: 623
  year: 2020
  end-page: 624
  ident: bib16
  article-title: COVID-19 and dexamethasone: a potential strategy to avoid steroid-related
  publication-title: JAMA
  contributor:
    fullname: Walker
– volume: 17
  start-page: 707
  year: 1996
  end-page: 718
  ident: bib49
  article-title: Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in
  publication-title: Neuron
  contributor:
    fullname: Ohshima
– volume: 4
  start-page: 2198
  year: 2013
  ident: bib29
  article-title: Dynamic switching between escape and avoidance regimes reduces
  publication-title: Nat. Commun.
  contributor:
    fullname: Glauser
– volume: 357
  start-page: 281
  year: 1995
  end-page: 295
  ident: bib20
  article-title: Sensory neuroanatomy of a skin-penetrating nematode parasite:
  publication-title: J. Comp. Neurol.
  contributor:
    fullname: Schad
– volume: 88
  start-page: 1052
  year: 2013
  end-page: 1061
  ident: bib9
  article-title: Molecular and biological diagnostic tests for monitoring benzimidazole resistance in human soil-transmitted helminths
  publication-title: Am. J. Trop. Med. Hyg.
  contributor:
    fullname: Prichard
– volume: 28
  start-page: 2338
  year: 2018
  end-page: 2347
  ident: bib22
  article-title: A critical role for thermosensation in host seeking by skin-penetrating nematodes
  publication-title: Curr. Biol.
  contributor:
    fullname: Hallem
– volume: 367
  start-page: 1521
  year: 2006
  end-page: 1532
  ident: bib2
  article-title: Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
  publication-title: Lancet
  contributor:
    fullname: Hotez
– volume: 144
  start-page: 327
  year: 2017
  end-page: 342
  ident: bib80
  article-title: Transgenesis in
  publication-title: Parasitology
  contributor:
    fullname: Li
– volume: 8
  start-page: 312
  year: 2006
  end-page: 320
  ident: bib7
  article-title: Parasites of the small intestine
  publication-title: Curr. Gastroenterol. Rep.
  contributor:
    fullname: Skopic
– volume: 21
  start-page: 353
  year: 2011
  end-page: 362
  ident: bib35
  article-title: Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling
  publication-title: Curr. Biol.
  contributor:
    fullname: Sengupta
– volume: 9
  start-page: 162
  year: 2015
  ident: bib56
  article-title: Unexpected variation in neuroanatomy among diverse nematode species
  publication-title: Front. Neuroanat.
  contributor:
    fullname: Schroeder
– volume: 13
  start-page: 78
  year: 2013
  ident: bib8
  article-title: Severe strongyloidiasis: a systematic review of case reports
  publication-title: BMC Infect. Dis.
  contributor:
    fullname: Bisoffi
– start-page: 1
  year: 2007
  end-page: 18
  ident: bib68
  article-title: a model for translational research on parasitic nematode biology
  publication-title: WormBook
  contributor:
    fullname: Lok
– volume: 26
  start-page: 7444
  year: 2006
  end-page: 7451
  ident: bib45
  article-title: The AFD sensory neurons encode multiple functions underlying thermotactic behavior in
  publication-title: J. Neurosci.
  contributor:
    fullname: Samuel
– year: 2009
  ident: bib65
  article-title: Ggplot2: Elegant Graphics for Data Analysis
  contributor:
    fullname: Wickham
– volume: 13
  start-page: e1006675
  year: 2017
  ident: bib48
  article-title: Targeted mutagenesis in a human-parasitic nematode
  publication-title: PLoS Pathog.
  contributor:
    fullname: Hallem
– volume: 206
  start-page: 55
  year: 2017
  end-page: 86
  ident: bib59
  article-title: The natural biotic environment of
  publication-title: Genetics
  contributor:
    fullname: Félix
– volume: 7
  start-page: 1429
  year: 2017
  end-page: 1437
  ident: bib78
  article-title: Reliable CRISPR/Cas9 genome engineering in
  publication-title: G3 (Bethesda)
  contributor:
    fullname: Boulin
– volume: 102
  start-page: 1386
  year: 2020
  end-page: 1395
  ident: bib5
  article-title: Prevalence of intestinal parasites in a low-income Texas community
  publication-title: Am. J. Trop. Med. Hyg.
  contributor:
    fullname: Mejia
– volume: 687
  start-page: 290
  year: 2018
  end-page: 303
  ident: bib19
  article-title: Temperature-dependent behaviors of parasitic helminths
  publication-title: Neurosci. Lett.
  contributor:
    fullname: Hallem
– volume: 13
  start-page: 517
  year: 2016
  ident: bib1
  article-title: Strongyloidiasis: a disease of socioeconomic disadvantage
  publication-title: Int. J. Environ. Res. Public Health
  contributor:
    fullname: Ross
– volume: 7
  start-page: R75
  year: 2006
  ident: bib79
  article-title: Codon usage patterns in Nematoda: analysis based on over 25 million codons in thirty-two species
  publication-title: Genome Biol.
  contributor:
    fullname: McCarter
– volume: 34
  start-page: 351
  year: 2020
  end-page: 362
  ident: bib31
  article-title: Temperature signaling underlying thermotaxis and cold tolerance in
  publication-title: J. Neurogenet.
  contributor:
    fullname: Kuhara
– volume: 6
  start-page: 26
  year: 2006
  ident: bib41
  article-title: Multiple lineage specific expansions within the guanylyl cyclase gene family
  publication-title: BMC Evol. Biol.
  contributor:
    fullname: Burnell
– volume: 178
  start-page: 1375
  year: 2019
  end-page: 1386.e11
  ident: bib53
  article-title: A cold-sensing receptor encoded by a glutamate receptor gene
  publication-title: Cell
  contributor:
    fullname: Kim
– volume: 470
  start-page: 839
  year: 2018
  end-page: 849
  ident: bib30
  article-title: The extraordinary AFD thermosensor of
  publication-title: Pflugers Arch.
  contributor:
    fullname: Sengupta
– volume: 32
  start-page: 268
  year: 2015
  end-page: 274
  ident: bib71
  article-title: IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies
  publication-title: Mol. Biol. Evol.
  contributor:
    fullname: Minh
– volume: 14
  start-page: 587
  year: 2017
  end-page: 589
  ident: bib72
  article-title: ModelFinder: fast model selection for accurate phylogenetic estimates
  publication-title: Nat. Methods
  contributor:
    fullname: Jermiin
– volume: 117
  start-page: 17913
  year: 2020
  end-page: 17923
  ident: bib24
  article-title: Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Hallem
– volume: 40
  start-page: 101981
  year: 2021
  ident: bib15
  article-title: Risk of
  publication-title: Infect. Dis.
  contributor:
    fullname: Woods
– volume: 84
  start-page: 297
  year: 1999
  end-page: 316
  ident: bib36
  article-title: Chemo- and thermosensory neurons: structure and function in animal parasitic nematodes
  publication-title: Vet. Parasitol.
  contributor:
    fullname: Schad
– volume: 6
  start-page: 26
  year: 2013
  ident: 10.1016/j.cub.2022.04.010_bib54
  article-title: Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2013.00026
  contributor:
    fullname: Bhargava
– volume: 139
  start-page: 993
  year: 1995
  ident: 10.1016/j.cub.2022.04.010_bib75
  article-title: A space-time process model for the evolution of DNA sequences
  publication-title: Genetics
  doi: 10.1093/genetics/139.2.993
  contributor:
    fullname: Yang
– volume: 215
  start-page: 2
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib70
  article-title: WormBase ParaSite − a comprehensive resource for helminth genomics
  publication-title: Mol. Biochem. Parasitol.
  doi: 10.1016/j.molbiopara.2016.11.005
  contributor:
    fullname: Howe
– volume: 48
  start-page: 299
  year: 2016
  ident: 10.1016/j.cub.2022.04.010_bib17
  article-title: The genomic basis of parasitism in the Strongyloides clade of nematodes
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3495
  contributor:
    fullname: Hunt
– volume: 7
  start-page: 30
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib33
  article-title: The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-7-30
  contributor:
    fullname: Chung
– year: 2005
  ident: 10.1016/j.cub.2022.04.010_bib60
  contributor:
    fullname: Roberts
– volume: 13
  start-page: 517
  year: 2016
  ident: 10.1016/j.cub.2022.04.010_bib1
  article-title: Strongyloidiasis: a disease of socioeconomic disadvantage
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph13050517
  contributor:
    fullname: Beknazarova
– start-page: 1
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib66
  article-title: Maintenance of C. elegans
  publication-title: WormBook
  contributor:
    fullname: Stiernagle
– volume: 470
  start-page: 839
  year: 2018
  ident: 10.1016/j.cub.2022.04.010_bib30
  article-title: The extraordinary AFD thermosensor of C. elegans
  publication-title: Pflugers Arch.
  doi: 10.1007/s00424-017-2089-5
  contributor:
    fullname: Goodman
– volume: 172
  start-page: 2239
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib39
  article-title: Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1534/genetics.105.050013
  contributor:
    fullname: Inada
– volume: 111
  start-page: 2770
  year: 2014
  ident: 10.1016/j.cub.2022.04.010_bib43
  article-title: Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1400615111
  contributor:
    fullname: Pokala
– volume: 11
  start-page: 908
  year: 2008
  ident: 10.1016/j.cub.2022.04.010_bib38
  article-title: Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2157
  contributor:
    fullname: Ramot
– volume: 144
  start-page: 263
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib6
  article-title: Human infection with Strongyloides stercoralis and other related Strongyloides species
  publication-title: Parasitology
  doi: 10.1017/S0031182016000834
  contributor:
    fullname: Nutman
– volume: 357
  start-page: 281
  year: 1995
  ident: 10.1016/j.cub.2022.04.010_bib20
  article-title: Sensory neuroanatomy of a skin-penetrating nematode parasite: Strongyloides stercoralis. I. Amphidial neurons
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.903570208
  contributor:
    fullname: Ashton
– volume: 34
  start-page: 351
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib31
  article-title: Temperature signaling underlying thermotaxis and cold tolerance in Caenorhabditis elegans
  publication-title: J. Neurogenet.
  doi: 10.1080/01677063.2020.1734001
  contributor:
    fullname: Takeishi
– volume: 13
  start-page: 78
  year: 2013
  ident: 10.1016/j.cub.2022.04.010_bib8
  article-title: Severe strongyloidiasis: a systematic review of case reports
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-13-78
  contributor:
    fullname: Buonfrate
– volume: 324
  start-page: 623
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib16
  article-title: COVID-19 and dexamethasone: a potential strategy to avoid steroid-related Strongyloides hyperinfection
  publication-title: JAMA
  doi: 10.1001/jama.2020.13170
  contributor:
    fullname: Stauffer
– volume: 299
  start-page: 1937
  year: 2008
  ident: 10.1016/j.cub.2022.04.010_bib10
  article-title: Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
  publication-title: JAMA
  doi: 10.1001/jama.299.16.1937
  contributor:
    fullname: Keiser
– volume: 90
  start-page: 235
  year: 2016
  ident: 10.1016/j.cub.2022.04.010_bib37
  article-title: Receptor-type guanylyl cyclases confer thermosensory responses in C. elegans
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.03.002
  contributor:
    fullname: Takeishi
– volume: 118
  start-page: 253
  year: 2008
  ident: 10.1016/j.cub.2022.04.010_bib69
  article-title: Strongyloides stercoralis: cell- and tissue-specific transgene expression and co-transformation with vector constructs incorporating a common multifunctional 3′ UTR
  publication-title: Exp. Parasitol.
  doi: 10.1016/j.exppara.2007.08.018
  contributor:
    fullname: Junio
– volume: 14
  start-page: 1291
  year: 2004
  ident: 10.1016/j.cub.2022.04.010_bib46
  article-title: The C. elegans thermosensory neuron AFD responds to warming
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2004.06.060
  contributor:
    fullname: Kimura
– volume: 24
  start-page: 2365
  year: 2010
  ident: 10.1016/j.cub.2022.04.010_bib28
  article-title: Running hot and cold: behavioral strategies, neural circuits, and the molecular machinery for thermotaxis in C. elegans and Drosophila
  publication-title: Genes Dev.
  doi: 10.1101/gad.1953710
  contributor:
    fullname: Garrity
– volume: 111
  start-page: 2776
  year: 2014
  ident: 10.1016/j.cub.2022.04.010_bib34
  article-title: Bidirectional thermotaxis in Caenorhabditis elegans is mediated by distinct sensorimotor strategies driven by the AFD thermosensory neurons
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1315205111
  contributor:
    fullname: Luo
– volume: 13
  start-page: e1006675
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib48
  article-title: Targeted mutagenesis in a human-parasitic nematode
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1006675
  contributor:
    fullname: Gang
– volume: 11
  start-page: jkab146
  year: 2021
  ident: 10.1016/j.cub.2022.04.010_bib81
  article-title: The Wild Worm Codon Adapter: a web tool for automated codon adaptation of transgenes for expression in non-Caenorhabditis nematodes
  publication-title: G3 (Bethesda)
  doi: 10.1093/g3journal/jkab146
  contributor:
    fullname: Bryant
– volume: 367
  start-page: 1521
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib2
  article-title: Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)68653-4
  contributor:
    fullname: Bethony
– volume: 178
  start-page: 1375
  year: 2019
  ident: 10.1016/j.cub.2022.04.010_bib53
  article-title: A cold-sensing receptor encoded by a glutamate receptor gene
  publication-title: Cell
  doi: 10.1016/j.cell.2019.07.034
  contributor:
    fullname: Gong
– volume: 72
  start-page: 4061
  year: 1975
  ident: 10.1016/j.cub.2022.04.010_bib25
  article-title: Normal and mutant thermotaxis in the nematode Caenorhabditis elegans
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.72.10.4061
  contributor:
    fullname: Hedgecock
– volume: 102
  start-page: 1386
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib5
  article-title: Prevalence of intestinal parasites in a low-income Texas community
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.19-0915
  contributor:
    fullname: Singer
– volume: 229
  start-page: 9
  year: 2016
  ident: 10.1016/j.cub.2022.04.010_bib11
  article-title: The development of anthelmintic resistance with best practice control of nematodes on commercial sheep farms in the UK
  publication-title: Vet. Parasitol.
  doi: 10.1016/j.vetpar.2016.09.006
  contributor:
    fullname: Learmount
– volume: 127
  start-page: 5317
  year: 2014
  ident: 10.1016/j.cub.2022.04.010_bib52
  article-title: Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron
  publication-title: J. Cell Sci.
  contributor:
    fullname: Nguyen
– volume: 173
  start-page: 131
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib42
  article-title: Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases
  publication-title: Genetics
  doi: 10.1534/genetics.106.055749
  contributor:
    fullname: Ortiz
– year: 2009
  ident: 10.1016/j.cub.2022.04.010_bib65
  contributor:
    fullname: Wickham
– volume: 687
  start-page: 290
  year: 2018
  ident: 10.1016/j.cub.2022.04.010_bib19
  article-title: Temperature-dependent behaviors of parasitic helminths
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2018.10.023
  contributor:
    fullname: Bryant
– volume: 96
  start-page: 10477
  year: 1999
  ident: 10.1016/j.cub.2022.04.010_bib26
  article-title: Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.96.18.10477
  contributor:
    fullname: Wittenburg
– volume: 102
  start-page: 3184
  year: 2005
  ident: 10.1016/j.cub.2022.04.010_bib51
  article-title: A circuit for navigation in Caenorhabditis elegans
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0409009101
  contributor:
    fullname: Gray
– volume: 142
  start-page: 437
  year: 2013
  ident: 10.1016/j.cub.2022.04.010_bib40
  article-title: GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis
  publication-title: J. Gen. Physiol.
  doi: 10.1085/jgp.201310959
  contributor:
    fullname: Wang
– volume: 8
  start-page: 312
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib7
  article-title: Parasites of the small intestine
  publication-title: Curr. Gastroenterol. Rep.
  doi: 10.1007/s11894-006-0052-2
  contributor:
    fullname: Schafer
– volume: 18
  start-page: 691
  year: 2001
  ident: 10.1016/j.cub.2022.04.010_bib73
  article-title: A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/oxfordjournals.molbev.a003851
  contributor:
    fullname: Whelan
– volume: 9
  start-page: 1499
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib62
  article-title: A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1796
  contributor:
    fullname: Biron
– volume: 66
  start-page: 1558
  year: 2018
  ident: 10.1016/j.cub.2022.04.010_bib12
  article-title: Strongyloidiasis outside endemic areas: long-term parasitological and clinical follow-up after ivermectin treatment
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix1069
  contributor:
    fullname: Repetto
– volume: 69
  start-page: e96
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib77
  article-title: Using ggtree to visualize data on tree-like structures
  publication-title: Curr. Protoc. Bioinformatics
  doi: 10.1002/cpbi.96
  contributor:
    fullname: Yu
– volume: 17
  start-page: 695
  year: 1996
  ident: 10.1016/j.cub.2022.04.010_bib50
  article-title: A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)80201-9
  contributor:
    fullname: Coburn
– volume: 9
  start-page: 162
  year: 2015
  ident: 10.1016/j.cub.2022.04.010_bib56
  article-title: Unexpected variation in neuroanatomy among diverse nematode species
  publication-title: Front. Neuroanat.
  contributor:
    fullname: Han
– volume: 6
  start-page: 26
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib41
  article-title: Multiple lineage specific expansions within the guanylyl cyclase gene family
  publication-title: BMC Evol. Biol.
  doi: 10.1186/1471-2148-6-26
  contributor:
    fullname: Fitzpatrick
– volume: 26
  start-page: 7444
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib45
  article-title: The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegans
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1137-06.2006
  contributor:
    fullname: Clark
– volume: 4
  start-page: 2198
  year: 2013
  ident: 10.1016/j.cub.2022.04.010_bib29
  article-title: Dynamic switching between escape and avoidance regimes reduces Caenorhabditis elegans exposure to noxious heat
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3198
  contributor:
    fullname: Schild
– start-page: 1
  year: 2014
  ident: 10.1016/j.cub.2022.04.010_bib83
  article-title: Thermotaxis navigation behavior
  publication-title: WormBook
  doi: 10.1895/wormbook.1.168.1
  contributor:
    fullname: Goodman
– volume: 9
  start-page: 468
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib13
  article-title: The global prevalence of Strongyloides stercoralis infection
  publication-title: Pathogens
  doi: 10.3390/pathogens9060468
  contributor:
    fullname: Buonfrate
– volume: 8
  start-page: 496
  year: 2018
  ident: 10.1016/j.cub.2022.04.010_bib23
  article-title: Terror in the dirt: sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes
  publication-title: Int. J. Parasitol. Drugs Drug Resist.
  doi: 10.1016/j.ijpddr.2018.10.008
  contributor:
    fullname: Bryant
– volume: 7
  start-page: 1429
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib78
  article-title: Reliable CRISPR/Cas9 genome engineering in Caenorhabditis elegans using a single efficient sgRNA and an easily recognizable phenotype
  publication-title: G3 (Bethesda)
  doi: 10.1534/g3.117.040824
  contributor:
    fullname: El Mouridi
– volume: 8
  start-page: 250
  year: 2011
  ident: 10.1016/j.cub.2022.04.010_bib82
  article-title: Codon adaptation-based control of protein expression in C. elegans
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1565
  contributor:
    fullname: Redemann
– volume: 32
  start-page: 268
  year: 2015
  ident: 10.1016/j.cub.2022.04.010_bib71
  article-title: IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msu300
  contributor:
    fullname: Nguyen
– volume: 14
  start-page: 587
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib72
  article-title: ModelFinder: fast model selection for accurate phylogenetic estimates
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4285
  contributor:
    fullname: Kalyaanamoorthy
– volume: 206
  start-page: 55
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib59
  article-title: The natural biotic environment of Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1534/genetics.116.195511
  contributor:
    fullname: Schulenburg
– volume: 144
  start-page: 327
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib80
  article-title: Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing
  publication-title: Parasitology
  doi: 10.1017/S0031182016000391
  contributor:
    fullname: Lok
– volume: 213
  start-page: 59
  year: 2019
  ident: 10.1016/j.cub.2022.04.010_bib55
  article-title: Using a robust and sensitive GFP-based cGMP sensor for real time imaging in intact Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1534/genetics.119.302392
  contributor:
    fullname: Woldemariam
– volume: 6
  start-page: e1582
  year: 2012
  ident: 10.1016/j.cub.2022.04.010_bib3
  article-title: A research agenda for helminth diseases of humans: the problem of helminthiases
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0001582
  contributor:
    fullname: Lustigman
– volume: 9
  start-page: 676
  year: 2012
  ident: 10.1016/j.cub.2022.04.010_bib63
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: Schindelin
– volume: 84
  start-page: 919
  year: 2014
  ident: 10.1016/j.cub.2022.04.010_bib61
  article-title: CaMKI-Dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.10.046
  contributor:
    fullname: Yu
– volume: 7
  start-page: R75
  year: 2006
  ident: 10.1016/j.cub.2022.04.010_bib79
  article-title: Codon usage patterns in Nematoda: analysis based on over 25 million codons in thirty-two species
  publication-title: Genome Biol.
  doi: 10.1186/gb-2006-7-8-r75
  contributor:
    fullname: Mitreva
– volume: 21
  start-page: 353
  year: 2011
  ident: 10.1016/j.cub.2022.04.010_bib35
  article-title: Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2011.01.053
  contributor:
    fullname: Wasserman
– volume: 37
  start-page: 599
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib76
  article-title: Treeio: an R package for phylogenetic tree input and output with richly annotated and associated data
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msz240
  contributor:
    fullname: Wang
– volume: 26
  start-page: R955
  year: 2016
  ident: 10.1016/j.cub.2022.04.010_bib58
  article-title: Nematode nervous systems
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2016.07.044
  contributor:
    fullname: Schafer
– volume: 8
  start-page: e47155
  year: 2019
  ident: 10.1016/j.cub.2022.04.010_bib57
  article-title: Evolution of neuronal anatomy and circuitry in two highly divergent nematode species
  publication-title: Elife
  doi: 10.7554/eLife.47155
  contributor:
    fullname: Hong
– volume: 58
  start-page: 140
  year: 1991
  ident: 10.1016/j.cub.2022.04.010_bib67
  article-title: Long-term storage of hookworm infective larvae in buffered saline solution maintains larval responsiveness to host signals
  publication-title: J. Helm Soc. Wash.
  contributor:
    fullname: Hawdon
– volume: 101
  start-page: 10554
  year: 2004
  ident: 10.1016/j.cub.2022.04.010_bib44
  article-title: Expanded dynamic range of fluorescent indicators for Ca2+ by circularly permuted yellow fluorescent proteins
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0400417101
  contributor:
    fullname: Nagai
– volume: 41
  start-page: 1149
  year: 2009
  ident: 10.1016/j.cub.2022.04.010_bib64
  article-title: Statistical power analyses using G∗Power 3.1: tests for correlation and regression analyses
  publication-title: Behav. Res. Methods
  doi: 10.3758/BRM.41.4.1149
  contributor:
    fullname: Faul
– volume: 84
  start-page: 297
  year: 1999
  ident: 10.1016/j.cub.2022.04.010_bib36
  article-title: Chemo- and thermosensory neurons: structure and function in animal parasitic nematodes
  publication-title: Vet. Parasitol.
  doi: 10.1016/S0304-4017(99)00037-0
  contributor:
    fullname: Ashton
– volume: 29
  start-page: 3345
  year: 2012
  ident: 10.1016/j.cub.2022.04.010_bib74
  article-title: The influence of rate heterogeneity among sites on the time dependence of molecular rates
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/mss140
  contributor:
    fullname: Soubrier
– volume: 40
  start-page: 101981
  year: 2021
  ident: 10.1016/j.cub.2022.04.010_bib15
  article-title: Risk of Strongyloides Hyperinfection Syndrome when prescribing dexamethasone in severe COVID-19. Travel Med
  publication-title: Infect. Dis.
  contributor:
    fullname: De Wilton
– volume: 100
  start-page: 1305
  year: 2019
  ident: 10.1016/j.cub.2022.04.010_bib14
  article-title: Morbidity associated with chronic Strongyloides stercoralis infection: a systematic review and meta-analysis
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.18-0895
  contributor:
    fullname: Tamarozzi
– volume: 28
  start-page: 2338
  year: 2018
  ident: 10.1016/j.cub.2022.04.010_bib22
  article-title: A critical role for thermosensation in host seeking by skin-penetrating nematodes
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2018.05.063
  contributor:
    fullname: Bryant
– volume: 376
  start-page: 344
  year: 1995
  ident: 10.1016/j.cub.2022.04.010_bib32
  article-title: Neural regulation of thermotaxis in Caenorhabditis elegans
  publication-title: Nature
  doi: 10.1038/376344a0
  contributor:
    fullname: Mori
– volume: 188
  start-page: 91
  year: 2011
  ident: 10.1016/j.cub.2022.04.010_bib27
  article-title: Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1534/genetics.111.127100
  contributor:
    fullname: Glauser
– volume: 17
  start-page: 707
  year: 1996
  ident: 10.1016/j.cub.2022.04.010_bib49
  article-title: Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)80202-0
  contributor:
    fullname: Komatsu
– start-page: 1
  year: 2007
  ident: 10.1016/j.cub.2022.04.010_bib68
  article-title: Strongyloides stercoralis: a model for translational research on parasitic nematode biology
  publication-title: WormBook
  contributor:
    fullname: Lok
– volume: 97
  start-page: 1623
  year: 2017
  ident: 10.1016/j.cub.2022.04.010_bib4
  article-title: Human intestinal parasite burden and poor sanitation in rural Alabama
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.17-0396
  contributor:
    fullname: McKenna
– volume: 30
  start-page: 1115
  year: 2000
  ident: 10.1016/j.cub.2022.04.010_bib21
  article-title: The neurons of class ALD mediate thermotaxis in the parasitic nematode, Strongyloides stercoralis
  publication-title: Int. J. Parasitol.
  doi: 10.1016/S0020-7519(00)00087-4
  contributor:
    fullname: Lopez
– volume: 6
  start-page: e1854
  year: 2012
  ident: 10.1016/j.cub.2022.04.010_bib18
  article-title: RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0001854
  contributor:
    fullname: Stoltzfus
– volume: 117
  start-page: 17913
  year: 2020
  ident: 10.1016/j.cub.2022.04.010_bib24
  article-title: Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1909710117
  contributor:
    fullname: Gang
– volume: 88
  start-page: 1052
  year: 2013
  ident: 10.1016/j.cub.2022.04.010_bib9
  article-title: Molecular and biological diagnostic tests for monitoring benzimidazole resistance in human soil-transmitted helminths
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.12-0484
  contributor:
    fullname: Diawara
– volume: 97
  start-page: 356
  year: 2018
  ident: 10.1016/j.cub.2022.04.010_bib47
  article-title: Integration of plasticity mechanisms within a single sensory neuron of C. elegans actuates a memory
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.12.027
  contributor:
    fullname: Hawk
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Snippet Soil-transmitted parasitic nematodes infect over one billion people and cause devastating morbidity worldwide. Many of these parasites have infective larvae...
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SubjectTerms AFD neuron
Animals
C. elegans
Caenorhabditis elegans
calcium imaging
heat seeking
Helminths
host-seeking
Hot Temperature
Humans
Larva - physiology
Nematoda - physiology
parasitic helminth
parasitic nematode
Strongyloides stercoralis
Strongyloides stercoralis - physiology
Thermoreceptors
thermosensation
thermotaxis
Title The neural basis of heat seeking in a human-infective parasitic worm
URI https://dx.doi.org/10.1016/j.cub.2022.04.010
https://www.ncbi.nlm.nih.gov/pubmed/35483361
https://search.proquest.com/docview/2658229973
https://pubmed.ncbi.nlm.nih.gov/PMC9158753
Volume 32
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