Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release

• Published in: Journal of molecular biology Vol. 430; no. 14; pp. 2080 - 2095
• Main Authors: Wong, Emily V., Gray, Shawn, Cao, Wenxiang, Montpetit, Rachel, Montpetit, Ben, De La Cruz, Enrique M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 06.07.2018
• Subjects: Dbp5; DEAD-box protein; Gle1; kinetics; Nup159; Gle1; NEFs; Nup159; Dbp5; DBP; DEAD-box protein; kinetics

Dbp5, DDX19 in humans, is an essential DEAD-box protein involved in mRNA export, which has also been linked to other cellular processes, including rRNA export and translation. Dbp5 ATPase activity is regulated by several factors, including RNA, the nucleoporin proteins Nup159 and Gle1, and the endog...