Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase

• Published in: Open life sciences Vol. 19; no. 1; pp. 20220832 - 63
• Main Authors: Zhang, Jun, Luo, Cheng, Long, Haiying
• Format: Journal Article
• Language: English
• Published: Poland De Gruyter 16.03.2024
• Subjects: acute myeloid leukemia; GLDC; SIRT5; succinylation; SIRT5; succinylation; acute myeloid leukemia; GLDC

Acute myeloid leukemia (AML) is a blood system malignancy where sirtuin 5 (SIRT5) is abnormally expressed in AML cell lines. This study aimed to investigate the SIRT5 effects on the viability and apoptosis of AML cell lines. The mRNA and protein expression levels of succinylation regulatory enzyme i...