Synthesis, investigation of biological effects and in silico studies of new benzimidazole derivatives as aromatase inhibitors

• Published in: Zeitschrift für Naturforschung C. A journal of biosciences Vol. 75; no. 9; pp. 353 - 362
• Main Authors: Sağlık, Begüm Nurpelin, Şen, Ahmet Mücahit, Evren, Asaf Evrim, Çevik, Ulviye Acar, Osmaniye, Derya, Kaya Çavuşoğlu, Betül, Levent, Serkan, Karaduman, Abdullah Burak, Özkay, Yusuf, Kaplancıklı, Zafer Asım
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 25.09.2020
• Subjects: active sites; ADME parameters; anticancer activity; antineoplastic activity; aromatase; aromatase enzyme; benzimidazole; biosynthesis; cisplatin; computer simulation; enzyme inhibition; estrogens; human cell lines; humans; molecular docking; aromatase enzyme; benzimidazole; molecular docking; anticancer activity; ADME parameters

Inhibition of aromatase enzymes is very important in the prevention of estrogen-related diseases and the regulation of estrogen levels. Aromatase enzyme is involved in the final stage of the biosynthesis of estrogen, in the conversion of androgens to estrogen. The development of new compounds for th...